YRC Public Data Repository - Protein Structure Prediction

Protein:	HPA3
Organism:	Saccharomyces cerevisiae
Length:	179 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HPA3.

Description	E-value	Query Range	Subject Range
HPA3 - D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mec... HPA3_YEAST - D-amino-acid N-acetyltransferase HPA3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HP...	1.0E-33	[1..179]	[1..179]
Y1207_METJA, YC0... - (Q58604) Hypothetical acetyltransferase MJ1207 (EC 2.3.1.-), Uncharacterized N-acetyltransferase MJ1... Y1207_METJA - Uncharacterized N-acetyltransferase MJ1207 OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM...	9.0E-28	[31..173]	[74..216]
gi\|7429961 - pir\|\|H70428 conserved hypothetical protein aq_1482 - Aquifex aeolicus gi\|2983873, gi\|1... - gi\|2983873\|gb\|AAC07426.1\| hypothetical protein aq_1482 [Aquifex aeolicus VF5], gi\|15606643\|ref\|NP_21...	7.0E-27	[31..179]	[8..153]
gi\|25521347, gi\|... - pir\|\|AB2684 acetyltransferase [imported] - Agrobacterium tumefaciens (strain C58, Dupont), pir\|\|H9... gi\|17934782, gi\|... - gi\|17934782\|ref\|NP_531572.1\| acetyltransferase [Agrobacterium tumefaciens str. C58], gi\|17739251\|gb\|...	9.0E-27	[1..173]	[1..177]
gi\|17133385, gi\|... - gi\|8489804\|gb\|AAF75760.1\|AF262218_2 putative acetyltransferase [Nostoc sp. PCC 7120], gi\|17231742\|re... gi\|25348432 - pir\|\|AC2337 hypothetical protein alr4250 [imported] - Nostoc sp. (strain PCC 7120)	3.0E-26	[26..175]	[1..151]
gi\|17429586 - gi\|17429586\|emb\|CAD16272.1\| putative acetyltransferase protein [Ralstonia solanacearum GMI1000] gi\|17547284 - gi\|17547284\|ref\|NP_520686.1\| putative acetyltransferase protein [Ralstonia solanacearum GMI1000]	1.0E-25	[22..166]	[1..144]
gi\|14521872, gi\|... - gi\|5459092\|emb\|CAB50578.1\| N-terminal acetyltransferase [Pyrococcus abyssi GE5], gi\|14521872\|ref\|NP_... gi\|5459092, gi\|7... - pir\|\|D75017 n-terminal acetyltransferase PAB1098 - Pyrococcus abyssi (strain Orsay), gi\|5459092\|emb...	3.0E-25	[32..179]	[20..150]

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Predicted Domain #1

Region A:
Residues: [1-179]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKTPDPSPP FASTKNVGMS NEEPEKMVND RIVVKAIEPK DEEAWNKLWK EYQGFQKTVM  60
   61 PPEVATTTFA RFIDPTVKLW GALAFDTETG DAIGFAHYLN HLTSWHVEEV VYMNDLYVTE 120
  121 RARVKGVGRK LIEFVYSRAD ELGTPAVYWV TDHYNHRAQL LYTKVAYKTD KVLYKRNGY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	457.190949
Match:	1qsmA_
Description:	Histone acetyltransferase HPA2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
N-acetyltransferase activity	6.09290029352595	bayes_pls_golite062009
N-acyltransferase activity	5.99007195691126	bayes_pls_golite062009
histone acetyltransferase activity	5.85159161781386	bayes_pls_golite062009
lysine N-acetyltransferase activity	5.85159161781386	bayes_pls_golite062009
acetyltransferase activity	4.88581443210764	bayes_pls_golite062009
	3.31223878955144	bayes_pls_golite062009
transferase activity	2.87429355361226	bayes_pls_golite062009
transferase activity, transferring acyl groups	2.48213335904382	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	2.37125669491841	bayes_pls_golite062009
acyltransferase activity	2.34144059663209	bayes_pls_golite062009
catalytic activity	1.97933499002461	bayes_pls_golite062009
binding	1.07749536895426	bayes_pls_golite062009
glycylpeptide N-tetradecanoyltransferase activity	0.952148883380044	bayes_pls_golite062009
myristoyltransferase activity	0.952148883380044	bayes_pls_golite062009
histone binding	0.582104626133107	bayes_pls_golite062009
nucleic acid binding	0.522132859536345	bayes_pls_golite062009
protein binding	0.283213965640071	bayes_pls_golite062009
transcription regulator activity	0.0766125702622449	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: