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View Structure Prediction Details

Protein: ESC2
Organism: Saccharomyces cerevisiae
Length: 456 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ESC2.

Description E-value Query
Range		 Subject
Range
ESC2 - Protein involved in silencing; may recruit or stabilize Sir proteins; role in Rad51-dependent homolo...
ESC2_YEAST - Protein ESC2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ESC2 PE=1 SV=1
gi|190404702 - gi|190404702|gb|EDV07969.1| hypothetical protein SCRG_00170 [Saccharomyces cerevisiae RM11-1a]
 0.0 [1..456] [1..456]
gi|2707597 - gi|2707597|gb|AAB92355.1| nonstructural protein P125-2 [pestivirus type 1]
 4.0E-50 [331..453] [28..142]
gi|14250087 - gi|14250087|gb|AAH08450.1| SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) [Homo sapiens]
gi|123992105, gi... - gi|123999434|gb|ABM87276.1| SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) [synthetic constr...
 3.0E-35 [362..453] [1..86]
SUMO3_MOUSE - Small ubiquitin-related modifier 3 OS=Mus musculus GN=Sumo3 PE=1 SV=1
 4.0E-35 [362..453] [1..85]
SMT3_ORYSA - Ubiquitin-like protein SMT3 - Oryza sativa (Rice)
gi|125528873, gi... - gi|149390685|gb|ABR25360.1| ubiquitin-like protein smt3 [Oryza sativa (indica cultivar-group)], gi|1...
SUMO1_ORYSJ - Small ubiquitin-related modifier 1 OS=Oryza sativa subsp. japonica GN=SUMO1 PE=1 SV=1
 8.0E-32 [362..455] [6..91]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 3.0E-31 [362..455] [1..94]
SUMO1_ARATH - Small ubiquitin-related modifier 1 OS=Arabidopsis thaliana GN=SUMO1 PE=1 SV=2
 1.0E-30 [372..455] [6..88]
gi|6433950 - gi|6433950|emb|CAB60728.1| SUMO protein [Solanum lycopersicum]
 6.0E-30 [371..455] [8..91]
gi|215736955, gi... - gi|34907008|ref|NP_914851.1| putative ubiquitin-like protein [Oryza sativa (japonica cultivar-group)...
gi|125528872 - gi|125528872|gb|EAY76986.1| hypothetical protein OsI_04942 [Oryza sativa Indica Group]
 9.0E-30 [363..455] [7..92]

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Predicted Domain #1
Region A:
Residues: [1-346] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGDSRSISE PSINLDPDNT SFSDENSDDF FMDNSYDIDE IDHSDESNRQ SVIVDSKVTV  60
   61 PPSKHSTLTL SDSEDSDAKE QHQSLSRSSS KNVNIEDITE PKPDKPSGRT RGRSVMKESV 120
  121 VEINSSESDL DEDKNFPRSR SRSRSSIRSI SPAGKYKRQK SSLLYTYDEN DDFFKELAKE 180
  181 AKKSTTISKE STPDQRKRVY NIKFLSKLEG TINKAVQVKV LGKYEFSKIL PAALDGLMKS 240
  241 YKIPKVMKDI YKVENVTLYW NNAKLLTFMT CNSLHIPQDF ENEVSDIDVT IVSKEYEKNF 300
  301 EATLESKLKE EEAALLIKER QEMERKLEKK RNEQEESEYR EFESEL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [347-456] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNVEETQEIK ENDTVMNTKL LQEGGSLSGN SSSMEEVMRI ALMGQDNKKI YVHVRRSTPF  60
   61 SKIAEYYRIQ KQLPQKTRVK LLFDHDELDM NECIADQDME DEDMVDVIID

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 28.30103
Match: 1a5r__
Description: SUMO-1 (smt3 homologue)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [355-456] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKENDTVMNT KLLQEGGSLS GNSSSMEEVM RIALMGQDNK KIYVHVRRST PFSKIAEYYR  60
   61 IQKQLPQKTR VKLLFDHDEL DMNECIADQD MEDEDMVDVI ID

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.522879
Match: 2awtA
Description: No description for 2awtA was found.

Predicted functions:

Term Confidence Notes
binding 2.786655943372 bayes_pls_golite062009
transcription regulator activity 2.21955949922709 bayes_pls_golite062009
nucleic acid binding 1.9984951714209 bayes_pls_golite062009
protein binding 1.86841453215444 bayes_pls_golite062009
DNA binding 1.86539227646379 bayes_pls_golite062009
GTPase regulator activity 0.334601927012824 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.315664702789604 bayes_pls_golite062009
enzyme regulator activity 0.162163146322721 bayes_pls_golite062009
structure-specific DNA binding 0.0368871434572171 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle