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View Structure Prediction Details

Protein: YDR333C
Organism: Saccharomyces cerevisiae
Length: 723 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YDR333C.

Description E-value Query
Range
Subject
Range
gi|207346436 - gi|207346436|gb|EDZ72929.1| YDR333Cp-like protein [Saccharomyces cerevisiae AWRI1631]
YDR333C - Putative protein of unknown function
RQC1_YEAST - Ribosome quality control complex subunit 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ...
gi|151942309 - gi|151942309|gb|EDN60665.1| conserved protein [Saccharomyces cerevisiae YJM789]
0.0 [1..713] [1..713]
gi|167773407 - gi|167773407|gb|ABZ92138.1| transcription factor 25 (basic helix-loop-helix) [synthetic construct]
TCF25 - transcription factor 25 (basic helix-loop-helix)
0.0 [1..666] [1..591]
FK26_MOUSE, FKS2... - (Q8R3L2) Protein FKSG26, (Q8R3L2) FKSG26 protein
0.0 [1..666] [1..591]
SPAC1142.01 - DUF654 family protein
gi|19115177 - gi|19115177|ref|NP_594265.1| hypothetical protein SPAC17G6.18 [Schizosaccharomyces pombe 972h-]
0.0 [1..670] [12..571]
CG7927-PA, FBpp0... - This gene is referred to in FlyBase by the symbol Dmel\CG7927 (CG7927, FBgn0027549). It is a protein...
gi|220953660 - gi|220953660|gb|ACL89373.1| CG7927-PA [synthetic construct]
0.0 [116..663] [22..567]
CE18019 - status:Partially_confirmed UniProt:P90919 protein_id:CAB03183.1
0.0 [274..663] [89..454]
gi|76363816 - gi|76363816|ref|XP_888619.1| hypothetical protein [Leishmania major strain Friedlin]
gi|12311834 - gi|12311834|emb|CAC22652.1| hypothetical protein L8032.10 [Leishmania major]
8.0E-98 [57..490] [122..511]

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Predicted Domain #1
Region A:
Residues: [1-298]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSRALRRLQ DDNALLESLL SNSNANKMTS GKSTAGNIQK RENIFSMMNN VRDSDNSTDE  60
   61 GQMSEQDEEA AAAGERDTQS NGQPKRITLA SKSSRRKKNK KAKRKQKNHT AEAAKDKGSD 120
  121 DDDDDEEFDK IIQQFKKTDI LKYGKTKNDD TNEEGFFTAS EPEEASSQPW KSFLSLESDP 180
  181 GFTKFPISCL RHSCKFFQND FKKLDPHTEF KLLFDDISPE SLEDIDSMTS TPVSPQQLKQ 240
  241 IQRLKRLIRN WGGKDHRLAP NGPGMHPQHL KFTKIRDDWI PTQRGELSMK LLSSDDLL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [299-353]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DWQLWERPLD WKDVIQNDVS QWQKFISFYK FEPLNSDLSK KSMMDFYLSV IVHPD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.718 a.164.1 C-terminal domain of DFF45/ICAD (DFF-C domain)
View Download 0.711 a.140.1 LEM domain
View Download 0.780 a.140.4 Recombination endonuclease VII, C-terminal and dimerization domains
View Download 0.733 a.140.4 Recombination endonuclease VII, C-terminal and dimerization domains
View Download 0.711 a.140.1 LEM domain
View Download 0.679 a.140.1 LEM domain
View Download 0.657 a.140.4 Recombination endonuclease VII, C-terminal and dimerization domains
View Download 0.657 a.140.4 Recombination endonuclease VII, C-terminal and dimerization domains
View Download 0.582 a.140.1 LEM domain
View Download 0.491 d.11.1 Penicillin-binding protein 2x (pbp-2x), c-terminal domain
View Download 0.491 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.469 a.140.4 Recombination endonuclease VII, C-terminal and dimerization domains
View Download 0.445 a.30.1 ROP protein
View Download 0.379 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.379 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.377 a.164.1 C-terminal domain of DFF45/ICAD (DFF-C domain)
View Download 0.370 a.144.2 Ribosomal protein L20
View Download 0.365 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.364 a.4.1 Homeodomain-like
View Download 0.346 a.140.1 LEM domain
View Download 0.331 a.140.4 Recombination endonuclease VII, C-terminal and dimerization domains
View Download 0.318 a.140.3 Rho termination factor, N-terminal domain
View Download 0.318 a.140.3 Rho termination factor, N-terminal domain
View Download 0.318 a.140.3 Rho termination factor, N-terminal domain
View Download 0.317 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.301 a.140.2 SAP domain
View Download 0.289 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.281 a.156.1 S13-like H2TH domain
View Download 0.277 a.77.1 DEATH domain
View Download 0.269 a.144.2 Ribosomal protein L20
View Download 0.267 a.140.2 SAP domain
View Download 0.263 f.14.1 Voltage-gated potassium channels
View Download 0.263 f.14.1 Voltage-gated potassium channels
View Download 0.262 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.254 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.253 a.7.7 BAG domain
View Download 0.253 g.58.1 Pheromone ER-23
View Download 0.252 a.144.2 Ribosomal protein L20
View Download 0.250 a.32.1 Transcription factor IIA (TFIIA), alpha-helical domain
View Download 0.249 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.244 a.140.4 Recombination endonuclease VII, C-terminal and dimerization domains
View Download 0.240 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.239 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.236 a.2.7 tRNA-binding arm
View Download 0.226 d.11.1 Penicillin-binding protein 2x (pbp-2x), c-terminal domain
View Download 0.223 a.46.1 Methionine synthase domain
View Download 0.223 a.140.1 LEM domain
View Download 0.221 d.11.1 Penicillin-binding protein 2x (pbp-2x), c-terminal domain
View Download 0.213 a.144.1 PABC (PABP) domain
View Download 0.209 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.209 a.140.1 LEM domain
View Download 0.209 d.58.11 EF-G/eEF-2 domains III and V
View Download 0.206 a.164.1 C-terminal domain of DFF45/ICAD (DFF-C domain)
View Download 0.205 a.77.1 DEATH domain
View Download 0.203 a.24.13 Domain of the SRP/SRP receptor G-proteins

Predicted functions:

Term Confidence Notes
binding 2.00861212399414 bayes_pls_golite062009
protein binding 1.51322932625387 bayes_pls_golite062009
transcription regulator activity 0.92511049170437 bayes_pls_golite062009
nucleic acid binding 0.777329345097548 bayes_pls_golite062009
DNA binding 0.67447901722682 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [354-477]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HEALINLISS KFPYHVPGLL QVALIFIRQG DRSNTNGLLQ RALFVFDRAL KANIIFDSLN  60
   61 CQLPYIYFFN RQFYLAIFRY IQSLAQRGVI GTASEWTKVL WSLSPLEDPL GCRYFLDHYF 120
  121 LLNN

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.73
Match: 1fchA
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [478-608]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DYQYIIELSN SPLMNCYKQW NTLGFSLAVV LSFLRINEMS SARNALLKAF KHHPLQLSEL  60
   61 FKEKLLGDHA LTKDLSIDGH SAENLELKAY MARFPLLWNR NEEVTFLHDE MSSILQDYHR 120
  121 GNVTIDSNDG Q

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 9.73
Match: 1fchA
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [609-723]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DHNNINNLQS PFFIAGIPIN LLRFAILSEE SSVMAAIPSF IWSDNEVYEF DVLPPMPTSK  60
   61 ESIEVVENIK TFINEKDLAV LQAERMQDED LLNQIRQISL QQYIHENEES NENEG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.282 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.315 a.22.1 Histone-fold
View Download 0.473 d.54.1 Enolase N-terminal domain-like
View Download 0.277 a.118.8 TPR-like
View Download 0.258 a.74.1 Cyclin-like
View Download 0.258 a.26.1 4-helical cytokines
View Download 0.249 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.243 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.241 d.54.1 Enolase N-terminal domain-like
View Download 0.234 f.14.1 Voltage-gated potassium channels
View Download 0.229 d.203.1 DsrC, the gamma subunit of dissimilatory sulfite reductase
View Download 0.201 a.133.1 Phospholipase A2, PLA2


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle