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View Structure Prediction Details

Protein: PRP42
Organism: Saccharomyces cerevisiae
Length: 544 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRP42.

Description E-value Query
Range
Subject
Range
PRP42 - U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatri...
PRP42_YEAST - U1 small nuclear ribonucleoprotein component PRP42 OS=Saccharomyces cerevisiae (strain ATCC 204508 /...
0.0 [1..544] [1..544]
gi|28201783, gi|... - sp|Q9BZJ0|CRN1_HUMAN Crooked neck-like protein 1 (Crooked neck homolog) (hCrn) (CGI-201) (MSTP021), ...
1.0E-58 [11..452] [226..739]
gi|46101125, gi|... - gi|71022837|ref|XP_761648.1| hypothetical protein UM05501.1 [Ustilago maydis 521], ref|XP_403116.1| ...
gi|14279385 - gi|14279385|gb|AAK58576.1|AF268097_1 TPR-containing protein Mql1 [Ustilago maydis]
1.0E-51 [9..364] [163..522]
CRNL1_MOUSE - Crooked neck-like protein 1 OS=Mus musculus GN=Crnkl1 PE=1 SV=1
CRNL1_RAT - Crooked neck-like protein 1 OS=Rattus norvegicus GN=Crnkl1 PE=2 SV=1
4.0E-50 [11..452] [65..578]
CYC8_SCHPO - General transcriptional corepressor ssn6 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=s...
ssn6 - transcriptional corepressor Ssn6
5.0E-50 [10..387] [351..719]
SYF1_RAT - Pre-mRNA-splicing factor SYF1 OS=Rattus norvegicus GN=Xab2 PE=2 SV=1
2.0E-48 [20..469] [228..673]

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Predicted Domain #1
Region A:
Residues: [1-193]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKYTALIHD ENFSTLTLNV SRYPKSLAYW EKLLNYIVKA SAPICKSTEP QLLKLIRCTY  60
   61 SSMLNEFPYL ENYYIDFALL EYKLGNVSMS HKIFQRGLQA FNQRSLLLWT SYLKFCNNVI 120
  121 SHQKQLFKKY ETAEEYVGLH FFSGEFWDLY LEQISSRCTS SKKYWNVLRK ILEIPLHSFS 180
  181 KFYALWLQRI DDI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.045757
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 2.76684454218635 bayes_pls_golite062009
binding 2.12690485191789 bayes_pls_golite062009
transcription regulator activity 1.26149030245805 bayes_pls_golite062009
DNA binding 0.9531600253493 bayes_pls_golite062009
protein binding 0.931467806305272 bayes_pls_golite062009
nucleic acid binding 0.93037889019021 bayes_pls_golite062009
transcription factor activity 0.374364600772076 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [194-290]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLKQLSQLT SKDELLKKLK IDINYSGRKG PYLQDAKKKL KKITKEMYMV VQYQVLEIYS  60
   61 IFESKIYINY YTSPETLVSS DEIETWIKYL DYTITLQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.045757
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [291-409]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDSLTHLNFQ RALLPLAHYD LVWIKYSKWL INSKNDLLGA KNVLLMGLKF SLKKTEIIKL  60
   61 LYSVICKLNE YVLLRNLLEK IESSYSDNVE NVDDFEIFWD YLQFKTFCQN SLYSSRYSD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.045757
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [410-544]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQSNGLLNKE LFDKVWKRLS CKEKKSGQEI LLNNLVQFYS KDTVEFVEKN IFQKIIEFGW  60
   61 EYYLQNGMFW NCYCRLIYFD TSRSYLDKRQ YIVRKIWPQI DKKFAQSVLP SLTEFCESYF 120
  121 PEEMDTLEEM FTEEP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.585 c.16.1 Lumazine synthase
View Download 0.512 d.124.1 Ribonuclease Rh-like
View Download 0.539 d.112.1 Phoshotransferase/anion transport protein
View Download 0.397 a.75.1 Ribosomal protein S7
View Download 0.464 a.118.12 Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain
View Download 0.395 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.359 a.118.8 TPR-like
View Download 0.335 a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.312 c.121.1 Ribose/Galactose isomerase RpiB/AlsB
View Download 0.312 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.297 a.85.1 Hemocyanin, N-terminal domain
View Download 0.277 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.273 a.118.9 ENTH/VHS domain
View Download 0.266 a.40.1 Calponin-homology domain, CH-domain
View Download 0.261 d.110.4 SNARE-like
View Download 0.259 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.256 a.91.1 Regulator of G-protein signalling, RGS
View Download 0.254 d.58.48 MTH1187-like
View Download 0.249 a.118.1 ARM repeat
View Download 0.245 a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.243 a.126.1 Serum albumin-like
View Download 0.240 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.237 d.58.34 Formiminotransferase domain of formiminotransferase-cyclodeaminase.
View Download 0.233 a.1.1 Globin-like
View Download 0.226 a.1.1 Globin-like
View Download 0.223 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.222 a.40.1 Calponin-homology domain, CH-domain
View Download 0.216 a.74.1 Cyclin-like
View Download 0.211 a.24.3 Cytochromes
View Download 0.204 d.58.26 GHMP Kinase, C-terminal domain
View Download 0.203 a.74.1 Cyclin-like
View Download 0.201 a.118.13 Arp2/3 complex 16 kDa subunit ARPC5


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle