YRC Public Data Repository - Protein Structure Prediction

Protein:	ADK1
Organism:	Saccharomyces cerevisiae
Length:	222 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ADK1.

Description	E-value	Query Range	Subject Range
ADK1 - Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; l... KAD2_YEAS1 - Adenylate kinase OS=Saccharomyces cerevisiae (strain RM11-1a) GN=ADK1 PE=3 SV=1 KAD2_YEAST - Adenylate kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADK1 PE=1 SV=2	6.0E-64	[1..222]	[1..222]
gi\|7434595, gi\|1... - gi\|7524346\|ref\|NP_037543.1\| adenylate kinase 2 isoform b [Homo sapiens], pir\|\|JC5893 adenylate kinas... gi\|109001656 - gi\|109001656\|ref\|XP_001106031.1\| PREDICTED: adenylate kinase 2 isoform 2 [Macaca mulatta] gi\|114555423 - gi\|114555423\|ref\|XP_513289.2\| PREDICTED: adenylate kinase 2 isoform 4 [Pan troglodytes]	1.0E-63	[4..221]	[13..229]
adk1 - adenylate kinase Adk1 KAD2_SCHPO - Adenylate kinase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=adk1 PE=1 SV=1	1.0E-63	[6..221]	[3..218]
gi\|4138286 - gi\|4138286\|emb\|CAA12055.1\| adenylate kinase [Neocallimastix frontalis]	5.0E-63	[3..221]	[6..223]
KAD2_MOUSE - Adenylate kinase isoenzyme 2, mitochondrial OS=Mus musculus GN=Ak2 PE=1 SV=4	7.0E-63	[4..221]	[13..229]
gi\|157834545, gi... - gi\|1633542\|pdb\|1AK2\| Chain , Adenylate Kinase Isoenzyme-2, gi\|1633467\|pdb\|2AK2\| Chain , Adenylat...	9.0E-63	[3..221]	[13..230]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	9.0E-63	[3..221]	[14..231]
KAD2_RAT - Adenylate kinase 2, mitochondrial OS=Rattus norvegicus GN=Ak2 PE=2 SV=2	1.0E-62	[4..221]	[13..229]

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Predicted Domain #1

Region A:
Residues: [1-222]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSESIRMV LIGPPGAGKG TQAPNLQERF HAAHLATGDM LRSQIAKGTQ LGLEAKKIMD  60
   61 QGGLVSDDIM VNMIKDELTN NPACKNGFIL DGFPRTIPQA EKLDQMLKEQ GTPLEKAIEL 120
  121 KVDDELLVAR ITGRLIHPAS GRSYHKIFNP PKEDMKDDVT GEALVQRSDD NADALKKRLA 180
  181 AYHAQTEPIV DFYKKTGIWA GVDASQPPAT VWADILNKLG KD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1272.69897
Match:	1aky__
Description:	Adenylate kinase; Microbial and mitochondrial ADK, insert "zinc finger" domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleobase, nucleoside, nucleotide kinase activity	5.63633783771436	bayes_pls_golite062009
nucleotide kinase activity	4.87013305162694	bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism	4.82340609517643	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	4.71956130169341	bayes_pls_golite062009
substrate-specific transporter activity	4.0949233879946	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	3.99447661719154	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	3.87925071606336	bayes_pls_golite062009
adenylate kinase activity	3.67594732794865	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.42302963379604	bayes_pls_golite062009
ion transmembrane transporter activity	3.18231927518784	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	3.06199686145935	bayes_pls_golite062009
cation transmembrane transporter activity	2.98215729643952	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
nucleic acid binding	2.11222585187695	bayes_pls_golite062009
DNA binding	1.7904783386531	bayes_pls_golite062009
transcription regulator activity	1.68903321260301	bayes_pls_golite062009
ribonucleotide binding	1.53142082854758	bayes_pls_golite062009
purine nucleotide binding	1.52938239070386	bayes_pls_golite062009
purine ribonucleotide binding	1.52887308780164	bayes_pls_golite062009
nucleotide binding	1.52746968836881	bayes_pls_golite062009
ATP binding	1.23942044024113	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
adenyl ribonucleotide binding	1.21044170258803	bayes_pls_golite062009
adenyl nucleotide binding	1.19481945569892	bayes_pls_golite062009
kinase activity	1.11120928120082	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
guanylate kinase activity	0.98934362137863	bayes_pls_golite062009
proton-transporting ATPase activity, rotational mechanism	0.938652092720669	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.908046791062776	bayes_pls_golite062009
structural constituent of ribosome	0.738234102557832	bayes_pls_golite062009
motor activity	0.68122766055454	bayes_pls_golite062009
cation-transporting ATPase activity	0.635625372639205	bayes_pls_golite062009
transcription factor activity	0.603758349693077	bayes_pls_golite062009
CTP synthase activity	0.554689818807922	bayes_pls_golite062009
microtubule motor activity	0.48522137429998	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.421921195209539	bayes_pls_golite062009
protein kinase activity	0.351308564667977	bayes_pls_golite062009
translation regulator activity	0.29096092258568	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.274994961137851	bayes_pls_golite062009
formate-tetrahydrofolate ligase activity	0.21533099279384	bayes_pls_golite062009
transferase activity	0.175269600441384	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	0.17485591642323	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009
structural molecule activity	0.0558641287316701	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: