YRC Public Data Repository - Protein Structure Prediction

Protein:	MGT1
Organism:	Saccharomyces cerevisiae
Length:	206 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MGT1.

Description	E-value	Query Range	Subject Range
MGT1 - DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA al...	6.0E-64	[1..206]	[1..206]
gi\|25286136 - pir\|\|E83777 O6-methylguanine DNA alkyltransferase dat [imported] - Bacillus halodurans (strain C-125... gi\|15613584, gi\|... - gi\|15613584\|ref\|NP_241887.1\| O6-methylguanine DNA alkyltransferase [Bacillus halodurans C-125], gi\|1...	8.0E-47	[20..198]	[3..170]
gi\|2935421 - gi\|2935421\|gb\|AAC25987.1\| adaptive response regulatory protein [Pseudoalteromonas sp. S9]	2.0E-46	[42..200]	[192..350]
gi\|18144000, gi\|... - gi\|18309324\|ref\|NP_561258.1\| methylated-DNA-protein-cystein methyltransferase [Clostridium perfringe...	2.0E-44	[20..199]	[5..159]
gi\|215410956, gi... - gi\|215410957\|ref\|ZP_03419765.1\| methylated-DNA--protein-cysteine methyltransferase [Mycobacterium tu... gi\|215403161, gi... - gi\|215403161\|ref\|ZP_03415342.1\| methylated-DNA--protein-cysteine methyltransferase [Mycobacterium tu... OGT_MYCTU - Methylated-DNA--protein-cysteine methyltransferase OS=Mycobacterium tuberculosis GN=ogt PE=1 SV=1 gi\|215430201 - gi\|215430201\|ref\|ZP_03428120.1\| methylated-DNA--protein-cysteine methyltransferase [Mycobacterium tu... gi\|215426644 - gi\|215426644\|ref\|ZP_03424563.1\| methylated-DNA--protein-cysteine methyltransferase [Mycobacterium tu... gi\|218753025 - gi\|218753025\|ref\|ZP_03531821.1\| methylated-DNA--protein-cysteine methyltransferase [Mycobacterium tu... gi\|121637246, gi... - gi\|121637246\|ref\|YP_977469.1\| putative methylated-DNA--protein-cysteine methyltransferase ogt [Mycob... gi\|215445494 - gi\|215445494\|ref\|ZP_03432246.1\| methylated-DNA--protein-cysteine methyltransferase [Mycobacterium tu... gi\|224989720, gi... - gi\|224989720\|ref\|YP_002644407.1\| putative methylated-DNA--protein-cysteine methyltransferase [Mycoba... OGT_MYCTO - Methylated-DNA--protein-cysteine methyltransferase OS=Mycobacterium tuberculosis (strain CDC 1551 / ... gi\|253321141, gi... - gi\|253799638\|ref\|YP_003032639.1\| methylated-DNA-protein-cysteine methyltransferase ogt [Mycobacteriu... gi\|254550324 - gi\|254550324\|ref\|ZP_05140771.1\| methylated-DNA--protein-cysteine methyltransferase [Mycobacterium tu... gi\|254815123 - gi\|254815123\|ref\|ZP_05220124.1\| methylated-DNA--protein-cysteine methyltransferase [Mycobacterium tu... gi\|255096099 - gi\|255096099\|ref\|ZP_05325577.1\| methylated-DNA--protein-cysteine methyltransferase [Mycobacterium tu... gi\|119701175, gi... - gi\|76784875\|ref\|ZP_00772055.1\| COG0350: Methylated DNA-protein cysteine methyltransferase [Mycobacte... gi\|81254727 - gi\|81254727\|ref\|ZP_00879236.1\| COG0350: Methylated DNA-protein cysteine methyltransferase [Mycobacte... gi\|167967588, gi... - gi\|167967588\|ref\|ZP_02549865.1\| methylated-DNA-protein-cysteine methyltransferase ogt [Mycobacterium... OGT_MYCTU - Methylated-DNA--protein-cysteine methyltransferase OS=Mycobacterium tuberculosis (strain ATCC 25618 ... OGT_MYCBO - Methylated-DNA--protein-cysteine methyltransferase OS=Mycobacterium bovis GN=ogt PE=3 SV=1 OGT_MYCBO - Methylated-DNA--protein-cysteine methyltransferase OS=Mycobacterium bovis (strain ATCC BAA-935 / AF2...	7.0E-44	[22..206]	[1..163]
gi\|167054339, gi... - gi\|167426650\|ref\|ZP_02318403.1\| ada regulatory protein [Yersinia pestis biovar Mediaevalis str. K197... gi\|229706633, gi... - gi\|229836185\|ref\|ZP_04456353.1\| bifunctional regulatory protein/DNA repair protein [Yersinia pestis ... gi\|166962740, gi... - gi\|167418746\|ref\|ZP_02310499.1\| ada regulatory protein [Yersinia pestis biovar Orientalis str. MG05-... gi\|229839921, gi... - gi\|229839921\|ref\|ZP_04460080.1\| bifunctional regulatory protein/DNA repair protein [Yersinia pestis ... gi\|229690313, gi... - gi\|229842003\|ref\|ZP_04462158.1\| bifunctional regulatory protein/DNA repair protein [Yersinia pestis ... gi\|167468390 - gi\|167468390\|ref\|ZP_02333094.1\| bifunctional regulatory protein/DNA repair protein [Yersinia pestis ... gi\|165915752, gi... - gi\|89103921\|ref\|ZP_01176481.1\| COG2169: Adenosine deaminase [Yersinia pestis biovar Orientalis str. ... gi\|22123991, gi\|... - gi\|22123991\|ref\|NP_667414.1\| O6-methylguanine-DNA methyltransferase; transcription activator/repress... gi\|25286162 - pir\|\|AH0009 methylated-DNA-[protein]-cysteine S-methyltransferase (EC 2.1.1.63) [imported] - Yersini... gi\|15978185, gi\|... - gi\|218927291\|ref\|YP_002345166.1\| bifunctional regulatory protein/DNA repair protein [Yersinia pestis... gi\|108813939, gi... - gi\|229904468\|ref\|ZP_04519579.1\| bifunctional regulatory protein/DNA repair protein [Yersinia pestis ... gi\|45434791, gi\|... - gi\|45439936\|ref\|NP_991475.1\| bifunctional regulatory protein/DNA repair protein [Yersinia pestis bio... gi\|108809462, gi... - gi\|108809462\|ref\|YP_653378.1\| bifunctional regulatory protein/DNA repair protein [Yersinia pestis An... gi\|166011470, gi... - gi\|166011470\|ref\|ZP_02232368.1\| ada regulatory protein [Yersinia pestis biovar Antiqua str. E1979001... gi\|165926103, gi... - gi\|165926103\|ref\|ZP_02221935.1\| ada regulatory protein [Yersinia pestis biovar Orientalis str. F1991... gi\|167399417, gi... - gi\|167399417\|ref\|ZP_02304941.1\| ada regulatory protein [Yersinia pestis biovar Antiqua str. UG05-045... gi\|166205146, gi... - gi\|166213744\|ref\|ZP_02239779.1\| ada regulatory protein [Yersinia pestis biovar Antiqua str. B4200300... gi\|150260866, gi... - gi\|150260866\|ref\|ZP_01917594.1\| bifunctional regulatory protein/DNA repair protein [Yersinia pestis ... gi\|145212770, gi... - gi\|145601074\|ref\|YP_001165150.1\| bifunctional regulatory protein/DNA repair protein [Yersinia pestis...	8.0E-44	[23..199]	[186..348]
gi\|13880961, gi\|... - gi\|15840768\|ref\|NP_335805.1\| methylated-DNA--protein-cysteine methyltransferase [Mycobacterium tuber...	1.0E-43	[22..206]	[9..171]
gi\|15677380, gi\|... - gi\|7226772\|gb\|AAF41883.1\| putative methylated-DNA--protein-cysteine methyltransferase [Neisseria men... gi\|11353793 - pir\|\|D81073 methylated-DNA-protein-cysteine methyltransferase, probable NMB1528 [imported] - Neisser...	2.0E-43	[28..200]	[92..264]
gi\|13362571, gi\|... - gi\|15832356\|ref\|NP_311129.1\| O6-methylguanine-DNA methyltransferase [Escherichia coli O157:H7], gi\|1... gi\|25286155, gi\|... - pir\|\|H85860 O6-methylguanine-DNA methyltransferase [imported] - Escherichia coli (strain O157:H7, su... gi\|15802766, gi\|... - gi\|15802766\|ref\|NP_288793.1\| O6-methylguanine-DNA methyltransferase; transcription activator/repress... gi\|13362571, gi\|... - gi\|15832356\|ref\|NP_311129.1\| O6-methylguanine-DNA methyltransferase [Escherichia coli O157:H7 str. S... gi\|208818942, gi... - gi\|208818942\|ref\|ZP_03259262.1\| regulatory protein Ada [Escherichia coli O157:H7 str. EC4042], gi\|20... gi\|208813133, gi... - gi\|208813133\|ref\|ZP_03254462.1\| regulatory protein Ada [Escherichia coli O157:H7 str. EC4045], gi\|20... gi\|217326795, gi... - gi\|217326795\|ref\|ZP_03442878.1\| regulatory protein Ada [Escherichia coli O157:H7 str. TW14588], gi\|2... gi\|209398796, gi... - gi\|209398796\|ref\|YP_002271626.1\| regulatory protein Ada [Escherichia coli O157:H7 str. EC4115], gi\|2... gi\|168803003, gi... - gi\|189375218\|gb\|EDU93634.1\| regulatory protein Ada [Escherichia coli O157:H7 str. EC508], gi\|1688030... gi\|189372959, gi... - gi\|189372959\|gb\|EDU91375.1\| regulatory protein Ada [Escherichia coli O157:H7 str. EC869], gi\|1687871... gi\|254794112, gi... - gi\|254794112\|ref\|YP_003078949.1\| fused DNA-binding transcriptional dual regulator, O6-methylguanine-... gi\|208809181, gi... - gi\|208809181\|ref\|ZP_03251518.1\| regulatory protein Ada [Escherichia coli O157:H7 str. EC4206], gi\|20... gi\|195935594 - gi\|195935594\|ref\|ZP_03080976.1\| O6-methylguanine-DNA methyltransferase [Escherichia coli O157:H7 str... gi\|168767837, gi... - gi\|189363020\|gb\|EDU81439.1\| regulatory protein Ada [Escherichia coli O157:H7 str. EC4486], gi\|168767... gi\|189365353, gi... - gi\|189365353\|gb\|EDU83769.1\| regulatory protein Ada [Escherichia coli O157:H7 str. EC4501], gi\|168764... gi\|189002004, gi... - gi\|189002004\|gb\|EDU70990.1\| regulatory protein Ada [Escherichia coli O157:H7 str. EC4076], gi\|168780... gi\|187771050, gi... - gi\|187771050\|gb\|EDU34894.1\| regulatory protein Ada [Escherichia coli O157:H7 str. EC4196], gi\|168773... gi\|168754964, gi... - gi\|189357736\|gb\|EDU76155.1\| regulatory protein Ada [Escherichia coli O157:H7 str. EC4401], gi\|168754... gi\|168749620, gi... - gi\|188016039\|gb\|EDU54161.1\| regulatory protein Ada [Escherichia coli O157:H7 str. EC4113], gi\|168749...	2.0E-43	[23..199]	[189..351]

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Predicted Domain #1

Region A:
Residues: [1-114]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHKKKIENGR IFDLNGPTMK ELLYYTFIET EVTGAFLVFR EKTQNLVFAS LGNDKLFLLG  60
   61 KVEGFLKKHE KQDTMYDLQE LKEAETYKKS IENYTICLEN KMPLPSGAIP FEFL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	232.69897
Match:	1sfe__
Description:	Ada DNA repair protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
methylated-DNA-[protein]-cysteine S-methyltransferase activity	3.81641972619245	bayes_pls_golite062009
S-methyltransferase activity	2.66007025371147	bayes_pls_golite062009
catalytic activity	1.90838528948382	bayes_pls_golite062009
DNA binding	1.54553435062678	bayes_pls_golite062009
nucleic acid binding	1.49720271661049	bayes_pls_golite062009
binding	1.30758209326705	bayes_pls_golite062009
transcription regulator activity	1.26332746912934	bayes_pls_golite062009
transferase activity	1.22815682532854	bayes_pls_golite062009
methyltransferase activity	1.14625481859451	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	1.13184530961695	bayes_pls_golite062009
transcription factor activity	0.99095733801135	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [115-206]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FGTDFQRKVW NELLNVEHGH VVTYGDIAKR IGKPTAARSV GRACGSNNLA LLVPCHRIVG  60
   61 SNRKLTGYKW SCKLKEQLLN NEKENSLSLS RL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	232.69897
Match:	1sfe__
Description:	Ada DNA repair protein
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: