YRC Public Data Repository - Protein Structure Prediction

Protein:	CYK3
Organism:	Saccharomyces cerevisiae
Length:	885 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYK3.

Description	E-value	Query Range	Subject Range
CYK3_YEAST - Cytokinesis protein 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CYK3 PE=1 SV=1 CYK3 - SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype a...	0.0	[1..885]	[1..885]
cyk3 - cytokinesis protein Cyk3 CYK3_SCHPO - cytokinesis protein 3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cyk3 PE=1 SV=1	0.0	[11..885]	[8..886]
gi\|15292465 - gi\|15292465\|gb\|AAK93501.1\| SD03168p [Drosophila melanogaster]	2.0E-88	[388..679]	[282..592]
gi\|7470126 - pir\|\|S74641 hypothetical protein sll1681 - Synechocystis sp. (strain PCC 6803) gi\|16329385, gi\|... - gi\|1651866\|dbj\|BAA16793.1\| sll1681 [Synechocystis sp. PCC 6803], gi\|16329385\|ref\|NP_440113.1\| hypoth...	2.0E-82	[426..713]	[110..385]
gi\|13936816 - gi\|13936816\|gb\|AAK49949.1\|AF339450_1 hillarin [Hirudo medicinalis]	5.0E-71	[446..675]	[605..833]
gi\|15004708, gi\|... - gi\|15004708\|ref\|NP_149168.1\| ChW repeat-/cell adhesion domain-containing transglutaminase-like prote...	5.0E-57	[417..635]	[424..634]
gi\|840708 - gi\|840708\|dbj\|BAA09334.1\| trans-sialidase [Trypanosoma cruzi]	5.0E-41	[47..422]	[640..1023]
gi\|6740102 - gi\|6740102\|gb\|AAF27527.1\| Crk-associated substrate p130Cas [Homo sapiens]	8.0E-40	[11..414]	[5..431]

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Predicted Domain #1

Region A:
Residues: [1-90]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATNLTSLKP PFKVKARYGW SGQTKGDLGF LEGDIMEVTR IAGSWFYGKL LRNKKCSGYF  60
   61 PHNFVILLEE RLNSSTENGR QPSKIVESFE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.69897
Match:	1k9aA_
Description:	Carboxyl-terminal src kinase (csk)
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [91-459]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSNKVVIPPV PSRYSDERPR PKKKLSSSMP NSPKKPVDSL TKARKAKSKE MVNEKNIYNT  60
   61 QSSRHHNNSA PNLPLASHSK PQVRNFEESM NNPLPPLPPL PDLDNMRKTD KRAPKKSYSA 120
  121 NDLHMARSSR EYNYYKDNQK FYDGFIPEKR YSLEEDSISS GLFSNSQYLN DSACSSENSF 180
  181 ALMSDFSATS AGSFARHKYA QSFSDSLQRS QNANGCSTKI NDSQEFGDSN ASSRNGKMGD 240
  241 ILRKIIIPKR NTNIYSSSVS SPKSPKAYPK LPDIQNLNLS ATPDEARDWI AVKCHLNRAR 300
  301 TLTKYDKHPR YMRALEENRD LILHPQDSIY NGLNTNEVKG NTKPGLVDVE LAELNIEYID 360
  361 KMTWKRCIR

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
hydrolase activity	0.895753300445801	bayes_pls_golite062009
catalytic activity	0.452849626127585	bayes_pls_golite062009
binding	0.139322852139959	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [460-621]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGTMTLDSWA QTTFSARYST VLEKLRGIYI FCTEMFALTD DNGTSDFSAE PQNLEKILYR  60
   61 KHCTPYELTW LFKKLANSLG ITCEIVIGFL KTPSAINWEF KYNHCWLRIL VNKEWRFIDV 120
  121 ILGNVTNPIH EFVNNRKIKK AENSYFLMAP LEMIYTHIPP RE

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	8.13
Match:	1e2tA
Description:	Arylamine N-acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [622-885]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FEQHIVPSID QLSALYLPLV FPSFFKNELK LYKFSTALSF LEDSEIYECS LEIPNDVEVF  60
   61 ASVVIPTDNE EASSAYRNME LALTQIKKQK AESGRRIALI KAVLPPNVNK GSLYIHSGVR 120
  121 GTQTSIANIH PLSMMVPLTH KGSNMKYEFV IKIPSESIQK IELYIVEPQS RYLFVGNEYS 180
  181 FEVIQSPSDG IVYSSDEGPN QNRKQPMAIK SPSGRVHELV KSDPHFPYGT WKGSIKIKEP 240
  241 GVWSALVIAD SGIGWSVFAE WLCV

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: