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View Structure Prediction Details

Protein: TRX3
Organism: Saccharomyces cerevisiae
Length: 127 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRX3.

Description E-value Query
Range		 Subject
Range
gi|190406501 - gi|190406501|gb|EDV09768.1| thioredoxin 3, mitochondrial precursor [Saccharomyces cerevisiae RM11-1a...
gi|151943894 - gi|151943894|gb|EDN62194.1| thioredoxin [Saccharomyces cerevisiae YJM789]
TRX3_YEAST - Thioredoxin-3, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRX3 PE=1 S...
TRX3 - Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasi...
 1.0E-33 [1..127] [1..127]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 5.0E-31 [1..127] [147..277]
gi|25282775 - pir||AD1813 thioredoxin [imported] - Nostoc sp. (strain PCC 7120)
gi|75702591, gi|... - gi|75908866|ref|YP_323162.1| thioredoxin [Anabaena variabilis ATCC 29413], gi|75702591|gb|ABA22267.1...
gi|7427614, gi|1... - gi|7427614|pir||TXAI thioredoxin 1 - Anabaena sp, gi|142118|gb|AAA22049.1| thioredoxin
THIO1_NOSSO - Thioredoxin-1 OS=Nostoc sp. (strain ATCC 29151 / PCC 7119) GN=trxA PE=1 SV=2
THIO1_NOSS1 - Thioredoxin-1 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=trxA PE=3 SV=2
 6.0E-31 [29..126] [6..105]
THIO_CYACA - Thioredoxin OS=Cyanidium caldarium GN=trxA PE=3 SV=1
 7.0E-31 [28..126] [5..105]
TRXM_PEA - Thioredoxin M-type, chloroplastic OS=Pisum sativum PE=2 SV=1
 8.0E-31 [20..126] [62..170]
TRXB_MYCLE - Bifunctional thioredoxin reductase/thioredoxin OS=Mycobacterium leprae GN=trxB/A PE=3 SV=1
TRXB_MYCLE - Bifunctional thioredoxin reductase/thioredoxin OS=Mycobacterium leprae (strain TN) GN=trxB/A PE=3 SV...
gi|219934045, gi... - gi|221230938|ref|YP_002504354.1| bifunctional thioredoxin reductase/thioredoxin [Mycobacterium lepra...
 9.0E-31 [16..127] [340..450]
THIO_PORPU - Thioredoxin OS=Porphyra purpurea GN=trxA PE=3 SV=1
 1.0E-30 [26..126] [2..104]

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Predicted Domain #1
Region A:
Residues: [1-127] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLFYKPVMRM AVRPLKSIRF QSSYTSITKL TNLTEFRNLI KQNDKLVIDF YATWCGPCKM  60
   61 MQPHLTKLIQ AYPDVRFVKC DVDESPDIAK ECEVTAMPTF VLGKDGQLIG KIIGANPTAL 120
  121 EKGIKDL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 221.36704
Match: 1erv__
Description: Thioredoxin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
antioxidant activity 3.8464796631544 bayes_pls_golite062009
peroxidase activity 3.43831566988273 bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor 3.43831566988273 bayes_pls_golite062009
glutathione peroxidase activity 2.56524997297011 bayes_pls_golite062009
protein disulfide isomerase activity 2.3913606099687 bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing S-S bonds 2.3913606099687 bayes_pls_golite062009
protein-disulfide reductase activity 2.24066563461479 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 2.23310780102446 bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting keto- and enol-groups 2.18667085747706 bayes_pls_golite062009
peroxiredoxin activity 2.12777217096121 bayes_pls_golite062009
selenium binding 1.97148144306198 bayes_pls_golite062009
thioredoxin peroxidase activity 1.96134566495756 bayes_pls_golite062009
disulfide oxidoreductase activity 1.32811008894503 bayes_pls_golite062009
binding 1.25802922431343 bayes_pls_golite062009
transcription regulator activity 0.96297634785608 bayes_pls_golite062009
catalytic activity 0.672192331361968 bayes_pls_golite062009
hydrolase activity 0.620302638089385 bayes_pls_golite062009
protein disulfide oxidoreductase activity 0.44918717550973 bayes_pls_golite062009
glutathione binding 0.2456976890622 bayes_pls_golite062009
transferase activity 0.245320538630117 bayes_pls_golite062009
protein binding 0.134341907247724 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle