YRC Public Data Repository - Protein Structure Prediction

Protein:	PET18
Organism:	Saccharomyces cerevisiae
Length:	215 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PET18.

Description	E-value	Query Range	Subject Range
gi\|7444017 - pir\|\|G64680 transcription regulator - Helicobacter pylori (strain 26695) gi\|15645900, gi\|... - gi\|2314455\|gb\|AAD08332.1\| transcriptional regulator (tenA) [Helicobacter pylori 26695], gi\|15645900\|...	2.0E-56	[2..215]	[1..217]
gi\|7444016 - pir\|\|C71837 probable transcription regulator - Helicobacter pylori (strain J99) gi\|4155800, gi\|1... - gi\|4155800\|gb\|AAD06775.1\| putative TRANSCRIPTIONAL REGULATOR [Helicobacter pylori J99], gi\|15612272\|...	1.0E-54	[2..215]	[1..217]
gi\|15622038, gi\|... - gi\|15921253\|ref\|NP_376922.1\| transcriptional activator [Sulfolobus tokodaii str. 7], gi\|15622038\|dbj...	6.0E-54	[3..213]	[1..207]
gi\|25300832 - pir\|\|G83984 transcription regulator of extracellular enzyme genes tenA [imported] - Bacillus halodur... TENA_BACHD - Aminopyrimidine aminohydrolase OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 /...	6.0E-54	[2..214]	[1..216]
gi\|207341377 - gi\|207341377\|gb\|EDZ69451.1\| YOL055Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190407290 - gi\|190407290\|gb\|EDV10557.1\| phosphomethylpyrimidine kinase THI20 [Saccharomyces cerevisiae RM11-1a] gi\|151945579 - gi\|151945579\|gb\|EDN63820.1\| thiamine metabolism-related protein [Saccharomyces cerevisiae YJM789] THI20 - Multifunctional protein with hydroxymethylpyrimidine phosphate (HMP-P) kinase and thiaminase activit... THI20_YEAST - Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20 OS=Saccharomyces cerevisiae (strain ATC...	1.0E-53	[2..214]	[331..549]
gi\|5458517, gi\|1... - gi\|5458517\|emb\|CAB50005.1\| Hypothetical protein, containing TENA/THI-4 domain [Pyrococcus abyssi GE5... gi\|5458517, gi\|7... - pir\|\|H75087 hypothetical protein PAB1641 - Pyrococcus abyssi (strain Orsay), gi\|5458517\|emb\|CAB50005...	2.0E-53	[3..213]	[1..208]
gi\|15603129, gi\|... - gi\|15603129\|ref\|NP_246201.1\| hypothetical protein PM1264 [Pasteurella multocida subsp. multocida str...	6.0E-53	[2..214]	[1..215]
gi\|18893444, gi\|... - gi\|18977710\|ref\|NP_579067.1\| transcriptional activator, putative [Pyrococcus furiosus DSM 3638], gi\|...	2.0E-52	[3..213]	[1..208]
gi\|7444018 - pir\|\|C71058 probable transcription regulator - Pyrococcus horikoshii gi\|14590988, gi\|... - gi\|3257578\|dbj\|BAA30261.1\| 218aa long hypothetical transcriptional regulator [Pyrococcus horikoshii ...	3.0E-52	[3..213]	[4..212]
gi\|189023455, gi... - gi\|189023455\|ref\|YP_001934223.1\| TENA/THI-4 protein [Brucella abortus S19], gi\|189019027\|gb\|ACD71749... gi\|82699121 - gi\|82699121\|ref\|YP_413695.1\| TENA/THI-4 protein [Brucella melitensis biovar Abortus 2308] gi\|62289184, gi\|... - gi\|62289184\|ref\|YP_220977.1\| transcriptional regulator TenA [Brucella abortus bv. 1 str. 9-941], gi\|... gi\|82615222 - gi\|82615222\|emb\|CAJ10169.1\| TENA/THI-4 protein [Brucella melitensis biovar Abortus 2308] gi\|237814674, gi... - gi\|237814674\|ref\|ZP_04593672.1\| transcriptional activator TENA [Brucella abortus str. 2308 A], gi\|23... gi\|254690507 - gi\|254690507\|ref\|ZP_05153761.1\| TENA/THI-4 protein [Brucella abortus bv. 6 str. 870] gi\|25300833 - pir\|\|AD3469 transcription activator tenA [imported] - Brucella melitensis (strain 16M) gi\|254696632 - gi\|254696632\|ref\|ZP_05158460.1\| TENA/THI-4 protein [Brucella abortus bv. 2 str. 86/8/59] gi\|17983766, gi\|... - gi\|17988021\|ref\|NP_540655.1\| transcriptional activator TENA [Brucella melitensis 16M], gi\|17983766\|g... gi\|254731540 - gi\|254731540\|ref\|ZP_05190118.1\| TENA/THI-4 protein [Brucella abortus bv. 4 str. 292]	1.0E-51	[7..215]	[15..230]

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Predicted Domain #1

Region A:
Residues: [1-112]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSCTTDKLIQ KYDALVRKTT EHKFAKELCA GTLKDRSLYI YLSQDLQFFE TSLRLICKTT  60
   61 SLAPTTHALI TLAKKIGFFS NDENSYFHDC LELLAPSLTK EERDNFDNKA IP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [157-176]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGLHWKYQKW IDLHDGEHFQ

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	9.12
Match:	1h0nA
Description:	Ribonucleotide reductase R2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.01565615669193	bayes_pls_golite062009
protein binding	0.645601172247564	bayes_pls_golite062009
catalytic activity	0.476060647762462	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [113-156]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVDAYINFLD ELRKDASITW PSLVTSLWVA EELYWRWARD TPRA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [177-215]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TWCEFLKAEV DKFPVEEVES IFVKVSQFEF EFFESCYNA

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	9.12
Match:	1h0nA
Description:	Ribonucleotide reductase R2
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: