YRC Public Data Repository - Protein Structure Prediction

Protein:	SPS22
Organism:	Saccharomyces cerevisiae
Length:	463 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPS22.

Description	E-value	Query Range	Subject Range
SPS22 - Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of t... SPS22_YEAST - Sporulation-specific protein 22 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPS22 PE...	0.0	[1..463]	[1..463]
meu10 - GPI anchored cell surface protein MEU10_SCHPO - Meiotic expression up-regulated protein 10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN...	8.0E-67	[53..402]	[11..351]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	1.0E-65	[40..407]	[17..373]
gi\|2388938 - gi\|2388938\|emb\|CAB11673.1\| SPAC1705.03c [Schizosaccharomyces pombe]	1.0E-60	[56..406]	[6..351]

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Predicted Domain #1

Region A:
Residues: [1-166]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRITRKSCL FAIIFASLFV THALGAAIDP PRRPHNVKPF HNGNLELQRR ANEPFFEIDV  60
   61 KSLNTNSPIS ELCKKDLHVI ESSHDLFHLQ NQCEFILGSL KVTNYDSNIL DLNSLRAIGG 120
  121 DLIIQDSPEL IRIQAGNLNK IEGLFQLQGL TSLVSVEIPT LKFCQS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	23.522879
Match:	1igrA_
Description:	Type 1 insulin-like growth factor receptor extracellular domain; Type 1 insulin-like growth factor receptor Cys-rich domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
receptor activity	1.64987101746707	bayes_pls_golite062009
transmembrane receptor activity	1.34503183418293	bayes_pls_golite062009
binding	1.08525898490902	bayes_pls_golite062009
protein binding	0.669091045213589	bayes_pls_golite062009
signal transducer activity	0.499118819144462	bayes_pls_golite062009
molecular transducer activity	0.499118819144462	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [167-411]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEWKVVPILN YVSMDSQNIE IIKDIVISDT SLANIENFNK VQEIDTFNIN NNRFLETIHS  60
   61 NVKTIRGQFS VHANAKELEL EMPHLREVEN ITIRDTSLVY LPQLTKVKSS LEFIENYFYE 120
  121 LNLNNLQKIG GTLGIINNVN LIKVNLENLT DIQGGLMIAD NESLEDITFL PNLKQIGGAI 180
  181 FFEGSFKDIM FDSLKLVKGS AFIKSSSNVL DCNKWTNPSN GRSIIRGGKF TCISGKKENT 240
  241 LNVKQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	8.0
Match:	1jl5A_
Description:	Leucine rich effector protein YopM
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [412-463]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGTIIEKGYK DLTQEGEDSK KRVISKYANS ANPSMQLDPL LFGTCLVAML LF

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.808	a.5.1	DNA helicase RuvA subunit, C-terminal domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: