YRC Public Data Repository - Protein Structure Prediction

Protein:	THI2
Organism:	Saccharomyces cerevisiae
Length:	450 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THI2.

Description	E-value	Query Range	Subject Range
gi\|151946626 - gi\|151946626\|gb\|EDN64848.1\| transcriptional activator [Saccharomyces cerevisiae YJM789] gi\|190408610 - gi\|190408610\|gb\|EDV11875.1\| thiamine biosynthesis regulatory protein [Saccharomyces cerevisiae RM11-... THI2 - Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynth... gi\|207347506 - gi\|207347506\|gb\|EDZ73654.1\| YBR240Cp-like protein [Saccharomyces cerevisiae AWRI1631] THI2_YEAST - Thiamine biosynthesis regulatory protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...	0.0	[1..450]	[1..450]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	3.0E-43	[4..272]	[6..286]
gi\|5059357 - gi\|5059357\|gb\|AAD38984.1\| unknown [Aspergillus niger]	2.0E-38	[16..272]	[3..284]
gi\|6561865, gi\|4... - gi\|6561865\|gb\|AAF17101.1\|AF208225_1 amylase cluster transcriptional regulator AmyR [Emericella nidul... gi\|67523119, gi\|... - gi\|67523119\|ref\|XP_659620.1\| hypothetical protein AN2016.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	6.0E-36	[17..272]	[3..281]
SPAC3C7.04 - transcription factor YF54_SCHPO - Uncharacterized transcriptional regulatory protein C3C7.04 OS=Schizosaccharomyces pombe (strain 972 ...	9.0E-35	[19..255]	[29..278]
AFLR_ASPFL - Aflatoxin biosynthesis regulatory protein OS=Aspergillus flavus GN=aflR PE=4 SV=1	5.0E-31	[1..232]	[1..243]
AFLR_ASPPA - Aflatoxin biosynthesis regulatory protein OS=Aspergillus parasiticus GN=aflR PE=2 SV=3	6.0E-31	[1..232]	[1..243]
gi\|14669834 - gi\|14669834\|dbj\|BAB62022.1\| xylanolytic transcriptional activator [Aspergillus kawachii]	1.0E-29	[5..236]	[30..237]
gi\|168849 - gi\|168849\|gb\|AAA33602.1\| pathway-specific regulatory protein [Neurospora crassa]	1.0E-29	[4..253]	[27..261]

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Predicted Domain #1

Region A:
Residues: [1-115]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVNSKRQQRS KKVASSSKVP PTKGRTFTGC WACRFKKRRC DENRPICSLC AKHGDNCSYD  60
   61 IRLMWLEENI YKVRKHSLIS SLQARKSKSK PLCQKISKSR FKQMTHFRQL SPPTS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11.39794
Match:	1pyiA_
Description:	PPR1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	4.56444258780502	bayes_pls_golite062009
DNA binding	4.26146437716972	bayes_pls_golite062009
nucleic acid binding	4.17369933547911	bayes_pls_golite062009
transcription factor activity	3.049435548132	bayes_pls_golite062009
sequence-specific DNA binding	2.98081393153291	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.93914501897006	bayes_pls_golite062009
binding	2.91929847152301	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	2.44382866473054	bayes_pls_golite062009
transcription activator activity	2.24483536326713	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [116-450]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DCEDSVHEAS KETTLPNDNT FTISVRRLKI YNNAVASVFG SMTNRDYTQK RIDKKLDELL  60
   61 NMVENDISVV NLNCSKHGPY SVFRANPAAV TSALTDQLPS PGHSMSSAEE TTTAALSSPP 120
  121 EDSTSLIDII QGKIFGILWF NCYGNMILNR QEYTTWFINK MRNSLTTEFI RFLGKIIDDP 180
  181 DINMASCLFK ECIARWSCVD WQSIAITMLV IIHGYTCPNL TKLLRVWFLQ QKLLRFSMYP 240
  241 LVNFIINNTQ DLDVLYHCNG LLGNADLFED PYQDELTSEL HVLVTERLVN SWKDTILQQL 300
  301 CSCQDTTLSC SQLRYWQLQL KCNQQFYKDV YAMQD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.462	a.60.9	lambda integrase-like, N-terminal domain
View	Download	0.415	a.74.1	Cyclin-like
View	Download	0.415	a.56.1	CO dehydrogenase ISP C-domain like
View	Download	0.410	a.118.11	Cytochrome c oxidase subunit E
View	Download	0.406	a.74.1	Cyclin-like

Predicted Domain #3

Region A:
Residues: [259-450]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNMILNRQEY TTWFINKMRN SLTTEFIRFL GKIIDDPDIN MASCLFKECI ARWSCVDWQS  60
   61 IAITMLVIIH GYTCPNLTKL LRVWFLQQKL LRFSMYPLVN FIINNTQDLD VLYHCNGLLG 120
  121 NADLFEDPYQ DELTSELHVL VTERLVNSWK DTILQQLCSC QDTTLSCSQL RYWQLQLKCN 180
  181 QQFYKDVYAM QD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: