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View Structure Prediction Details

Protein: BEM1
Organism: Saccharomyces cerevisiae
Length: 551 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BEM1.

Description E-value Query
Range
Subject
Range
gi|190408648 - gi|190408648|gb|EDV11913.1| bud emergence protein 1 [Saccharomyces cerevisiae RM11-1a]
gi|151946588 - gi|151946588|gb|EDN64810.1| bud emergence protein [Saccharomyces cerevisiae YJM789]
gi|207347574 - gi|207347574|gb|EDZ73700.1| YBR200Wp-like protein [Saccharomyces cerevisiae AWRI1631]
BEM1_YEAST - Bud emergence protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BEM1 PE=1 SV=1
BEM1 - Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions ...
0.0 [1..551] [1..551]
scd2 - scaffold protein Scd2
SCD2_SCHPO - Protein scd2/ral3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=scd2 PE=3 SV=1
3.0E-79 [69..511] [21..492]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
3.0E-68 [7..366] [249..618]
SRC_RSVSA - Tyrosine-protein kinase transforming protein Src OS=Avian leukosis virus RSA GN=V-SRC PE=1 SV=5
gi|210189 - gi|210189|gb|AAA42565.1| src-p60 phosphoprotein
SRC_AVISR - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain rASV1441) GN=V-SRC P...
6.0E-67 [7..366] [3..372]
SRC_AVISS - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain S1) GN=V-SRC PE=3 SV...
2.0E-66 [7..366] [3..372]
SRC_CHICK - Proto-oncogene tyrosine-protein kinase Src OS=Gallus gallus GN=SRC PE=1 SV=4
2.0E-66 [7..366] [3..372]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-66 [7..366] [3..372]
gi|210265 - gi|210265|gb|AAA42583.1| p66-src protein
gi|394713 - gi|394713|emb|CAA36156.1| src protein [Avian sarcoma virus]
SRC_AVIS2 - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain PR2257) GN=V-SRC PE=...
3.0E-66 [7..366] [3..372]
SRC_AVIST - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain S2) GN=V-SRC PE=3 SV...
5.0E-66 [7..366] [3..372]

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Predicted Domain #1
Region A:
Residues: [1-66]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKNFKLSKR DSNGSKGRIT SADISTPSHD NGSVIKHIKT VPVRYLSSSS TPVKSQRDSS  60
   61 PKNRHN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 3.12724619324809 bayes_pls_golite062009
signal transducer activity 2.5284324342567 bayes_pls_golite062009
molecular transducer activity 2.5284324342567 bayes_pls_golite062009
protein binding 2.14586566310919 bayes_pls_golite062009
molecular adaptor activity 1.33740973673697 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.2323381312171 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
cytoskeletal protein binding 0.83493091348808 bayes_pls_golite062009
actin filament binding 0.75424908168927 bayes_pls_golite062009
transcription regulator activity 0.540818657754841 bayes_pls_golite062009
enzyme regulator activity 0.456661966897198 bayes_pls_golite062009
nucleic acid binding 0.352421112301971 bayes_pls_golite062009
DNA binding 0.281643350069021 bayes_pls_golite062009
phosphoprotein binding 0.16798254471727 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [67-133]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKDITSPEKV IKAKYSYQAQ TSKELSFMEG EFFYVSGDEK DWYKASNPST GKEGVVPKTY  60
   61 FEVFDRT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 91.24799
Match: 2ptk__
Description: c-src protein tyrosine kinase; c-src tyrosine kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [134-238]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPSSVNGSNS SSRKVTNDSL NMGSLYAIVL YDFKAEKADE LTTYVGENLF ICAHHNCEWF  60
   61 IAKPIGRLGG PGLVPVGFVS IIDIATGYAT GNDVIEDIKS VNLPT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 91.24799
Match: 2ptk__
Description: c-src protein tyrosine kinase; c-src tyrosine kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.24212855645397 bayes_pls_golite062009
protein binding 1.04550817342273 bayes_pls_golite062009
signal transducer activity 0.639296022362811 bayes_pls_golite062009
molecular transducer activity 0.639296022362811 bayes_pls_golite062009
GTPase regulator activity 0.459633124432679 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.457933659119243 bayes_pls_golite062009
small GTPase regulator activity 0.390993828682912 bayes_pls_golite062009
enzyme regulator activity 0.217422685675578 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.187012142094005 bayes_pls_golite062009
protein serine/threonine kinase activity 0.0693380673720717 bayes_pls_golite062009
protein kinase activity 0.0278354564906339 bayes_pls_golite062009
kinase activity 0.00999242592237526 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [239-366]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VQEWKSNIAR YKASNISLGS VEQQQQQSIT KPQNKSAKLV DGELLVKASV ESFGLEDEKY  60
   61 WFLVCCELSN GKTRQLKRYY QDFYDLQVQL LDAFPAEAGK LRDAGGQWSK RIMPYIPGPV 120
  121 PYVTNSIT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 91.24799
Match: 2ptk__
Description: c-src protein tyrosine kinase; c-src tyrosine kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [367-434]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKRKEDLNIY VADLVNLPDY ISRSEMVHSL FVVLNNGFDR EFERDENQNN IKTLQENDTA  60
   61 TFATASQT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 77.156545
Match: 1gd5A_
Description: p47phox NADPH oxidase
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [435-551]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNFASTNQDN TLTGEDLKLN KKLSDLSLSG SKQAPAQSTS GLKTTKIKFY YKDDIFALML  60
   61 KGDTTYKELR SKIAPRIDTD NFKLQTKLFD GSGEEIKTDS QVSNIIQAKL KISVHDI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 405.144602
Match: 1ip9A_
Description: Bud emergence mediator Bemp1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle