YRC Public Data Repository - Protein Structure Prediction

Protein:	DTR1
Organism:	Saccharomyces cerevisiae
Length:	572 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DTR1.

Description	E-value	Query Range	Subject Range
DTR1 - Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; me... DTR1_YEAST - Dityrosine transporter 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DTR1 PE=1 SV=1	8.0E-94	[1..572]	[1..572]
gi\|15927932, gi\|... - gi\|15927932\|ref\|NP_375465.1\| hypothetical protein SA2142 [Staphylococcus aureus subsp. aureus N315],... gi\|253314692 - gi\|253314692\|ref\|ZP_04837905.1\| hypothetical protein SauraC_00665 [Staphylococcus aureus subsp. aure... gi\|12003106, gi\|... - pir\|\|C90035 hypothetical protein SA2142 [imported] - Staphylococcus aureus (strain N315), gi\|120031... gi\|255007128 - gi\|255007128\|ref\|ZP_05145729.2\| hypothetical protein SauraM_11685 [Staphylococcus aureus subsp. aure... gi\|14248126, gi\|... - gi\|15925342\|ref\|NP_372876.1\| multidrug resistance protein [Staphylococcus aureus subsp. aureus Mu50]... gi\|269203983\|ref... - EmrB/QacA family drug resistance transporter [Staphylococcus aureus subsp. aureus ED98] gi\|90583610, gi\|... - gi\|90583610\|ref\|ZP_01239364.1\| Drug resistance transporter EmrB/QacA subfamily [Staphylococcus aureu... gi\|147741858, gi... - gi\|90585929\|ref\|ZP_01241634.1\| Drug resistance transporter EmrB/QacA subfamily [Staphylococcus aureu... gi\|156980667, gi... - gi\|156980667\|ref\|YP_001442926.1\| hypothetical protein SAHV_2336 [Staphylococcus aureus subsp. aureus...	1.0E-83	[7..530]	[26..540]
gi\|21225257, gi\|... - gi\|7649556\|emb\|CAB89031.1\| putative membrane transport protein. [Streptomyces coelicolor A3(2)], gi\|...	2.0E-82	[84..536]	[6..440]
gi\|13702155, gi\|... - gi\|13702161\|dbj\|BAB43818.1\| CaNAG4 [Candida albicans], gi\|13702155\|dbj\|BAB43815.1\| CaNAG4 [Candida a... gi\|238882925 - gi\|238882925\|gb\|EEQ46563.1\| hypothetical protein CAWG_04919 [Candida albicans WO-1]	7.0E-82	[9..565]	[20..563]
YCT4_SCHPO - Uncharacterized transporter C794.04c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC7... SPCC794.04c - membrane transporter	1.0E-78	[23..570]	[24..539]
gi\|25498023 - pir\|\|D96902 MDR-type permease [imported] - Clostridium acetobutylicum gi\|15893318, gi\|... - gi\|15893318\|ref\|NP_346667.1\| MDR-type permease [Clostridium acetobutylicum ATCC 824], gi\|15022839\|gb...	1.0E-78	[104..536]	[1..414]
lcl\|NC_016856.1_... - [gene=emrB] [protein=putative multidrug transport protein] [protein_id=YP_005238915.1] [location=298... gi\|16766126, gi\|... - gi\|16766126\|ref\|NP_461741.1\| putative multidrug transport protein [Salmonella typhimurium LT2], gi\|1... gi\|167992539, gi... - gi\|205329344\|gb\|EDZ16108.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica sero...	2.0E-77	[107..535]	[10..422]
gi\|16761596 - gi\|16761596\|ref\|NP_457213.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ser... gi\|25306158, gi\|... - gi\|25306158\|pir\|\|AG0842 multidrug resistance protein B [imported] - Salmonella enterica subsp. enter... gi\|29138709, gi\|... - gi\|29143076\|ref\|NP_806418.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ser... gi\|213850377 - gi\|213850377\|ref\|ZP_03381275.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ... gi\|214000013 - gi\|214000013\|ref\|ZP_03410748.1\| multidrug resistance protein B [Salmonella enterica subsp. enterica ...	4.0E-77	[107..535]	[10..422]
gi\|229896373, gi... - gi\|229896373\|ref\|ZP_04511542.1\| multidrug resistance protein B [Yersinia pestis Pestoides A], gi\|229... gi\|229899449, gi... - gi\|229899449\|ref\|ZP_04514592.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|165926632, gi... - gi\|165926632\|ref\|ZP_02222464.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|22124829, gi\|... - gi\|22124829\|ref\|NP_668252.1\| multidrug resistance protein B [Yersinia pestis KIM], gi\|21957657\|gb\|AA... gi\|166213072, gi... - gi\|166213072\|ref\|ZP_02239107.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|25306154 - pir\|\|AB0397 multidrug resistance protein B [imported] - Yersinia pestis (strain CO92) gi\|165990079, gi... - gi\|166011079\|ref\|ZP_02231977.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|51595205, gi\|... - gi\|51595205\|ref\|YP_069396.1\| MFS multidrug efflux pump, emrB subunit [Yersinia pseudotuberculosis IP... gi\|45435371, gi\|... - gi\|45440514\|ref\|NP_992053.1\| multidrug resistance protein B [Yersinia pestis biovar Microtus str. 91... gi\|218930293, gi... - gi\|218930293\|ref\|YP_002348168.1\| multidrug resistance protein B [Yersinia pestis CO92], gi\|16123425\|... gi\|149364891, gi... - gi\|149364891\|ref\|ZP_01886926.1\| multidrug resistance protein B [Yersinia pestis CA88-4125], gi\|14929... gi\|145211859, gi... - gi\|145600163\|ref\|YP_001164239.1\| multidrug resistance protein B [Yersinia pestis Pestoides F], gi\|14... gi\|167421612, gi... - gi\|167421612\|ref\|ZP_02313365.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st... gi\|167051986, gi... - gi\|167399482\|ref\|ZP_02305006.1\| multidrug resistance protein B [Yersinia pestis biovar Antiqua str. ... gi\|170025556, gi... - gi\|170025556\|ref\|YP_001722061.1\| EmrB/QacA family drug resistance transporter [Yersinia pseudotuberc... gi\|167057491, gi... - gi\|167423321\|ref\|ZP_02315074.1\| multidrug resistance protein B [Yersinia pestis biovar Mediaevalis s... gi\|162354357, gi... - gi\|77633286\|ref\|ZP_00795425.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... gi\|89103813, gi\|... - gi\|89103813\|ref\|ZP_01176376.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pes... Q66E38\|Q66E38_YERPS - MFS multidrug efflux pump, emrB subunit - Yersinia pseudotuberculosis gi\|186894223, gi... - gi\|186894223\|ref\|YP_001871335.1\| EmrB/QacA family drug resistance transporter [Yersinia pseudotuberc... gi\|153950510, gi... - gi\|77631828\|ref\|ZP_00794414.1\| COG0477: Permeases of the major facilitator superfamily [Yersinia pse... gi\|108808750, gi... - gi\|108808750\|ref\|YP_652666.1\| multidrug resistance protein B [Yersinia pestis Antiqua], gi\|108780663... gi\|229901211, gi... - gi\|229901211\|ref\|ZP_04516333.1\| multidrug resistance protein B [Yersinia pestis Nepal516], gi\|229681... gi\|229695246, gi... - gi\|229838880\|ref\|ZP_04459039.1\| multidrug resistance protein B [Yersinia pestis biovar Orientalis st...	1.0E-76	[111..536]	[13..422]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	2.0E-75	[82..536]	[14..456]

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Predicted Domain #1

Region A:
Residues: [1-83]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSEPFQKKN LGLQINSQES GTTRSTFHSL EDLGDDVINE SWDQVNQKRA NIDHDVFHEH  60
   61 PDSSPSLSAQ KAKTKEEEVA VKS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.365	a.4.1	Homeodomain-like
View	Download	0.452	a.4.9	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View	Download	0.395	a.60.5	Barrier-to-autointegration factor, BAF
View	Download	0.373	a.118.11	Cytochrome c oxidase subunit E
View	Download	0.709	a.65.1	Annexin
View	Download	0.452	a.4.9	Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View	Download	0.425	a.65.1	Annexin
View	Download	0.395	a.60.5	Barrier-to-autointegration factor, BAF
View	Download	0.373	a.118.11	Cytochrome c oxidase subunit E
View	Download	0.365	a.44.1	Disulphide-bond formation facilitator (DSBA), insertion domain
View	Download	0.352	a.3.1	Cytochrome c
View	Download	0.340	d.109.1	Actin depolymerizing proteins
View	Download	0.328	a.118.14	FliG
View	Download	0.315	a.51.1	Cytochrome c oxidase subunit h
View	Download	0.291	a.36.1	Signal peptide-binding domain
View	Download	0.273	a.4.6	C-terminal effector domain of the bipartite response regulators
View	Download	0.252	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.246	a.181.1	Antibiotic binding domain of TipA-like multidrug resistance regulators
View	Download	0.244	d.211.1	Ankyrin repeat
View	Download	0.244	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.236	a.46.2	Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View	Download	0.235	a.37.1	A DNA-binding domain in eukaryotic transcription factors
View	Download	0.223	d.192.1	YlxR-like
View	Download	0.223	a.60.13	Putative methyltransferase TM0872, insert domain
View	Download	0.209	a.144.1	PABC (PABP) domain
View	Download	0.208	a.4.1	Homeodomain-like

Predicted Domain #2

Region A:
Residues: [84-572]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNSQSRDPSP DTQAHIPYTY FSKDQRLIIF GIIIFIGFLG PMSGNIYIPA LPLLQREYDV  60
   61 SATTINATVS VFMAVFSVGP LFWGALADFG GRKFLYMVSL SLMLIVNILL AAVPVNIAAL 120
  121 FVLRIFQAFA SSSVISLGAG TVTDVVPPKH RGKAIAYFMM GPNMGPIIAP IVAGLILMKG 180
  181 NYWRWLFGFT SIMTGIALIL VTALLPETLR CIVGNGDPKW GDKKDERENN ESPFFEGNKI 240
  241 SHRRLFPDIG IRKPVNNDAF FQENFPKPPK AGLTLYWKMI KCPPIIITSV STALLFSSYY 300
  301 AFSVTFSYYL EHDYRFTMLE IGAAYVCPGV AMLLGSQSGG HLSDYLRSRW IKSHPKKKFP 360
  361 AEFRLLLNLI GILLTICGTI GYGWAIFFHY HFVVLLVFSA LTAFGMTWCS NTSMTYLTEL 420
  421 FPKRAAGTVA VSSFFRNVGA AISSAIILQL CNAMGIGWCF TGLGLCSSIS LIGILYLLIF 480
  481 QRKYTAKEF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	19.154902
Match:	1ja5A_
Description:	No description for 1ja5A_ was found.

Predicted functions:

Term	Confidence	Notes
substrate-specific transmembrane transporter activity	5.46247398538901	bayes_pls_golite062009
ion transmembrane transporter activity	4.58978526526921	bayes_pls_golite062009
cation transmembrane transporter activity	4.31967711223954	bayes_pls_golite062009
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
binding	1.3181781780038	bayes_pls_golite062009
organic acid transmembrane transporter activity	1.24937104052238	bayes_pls_golite062009
anion transmembrane transporter activity	1.24023641504332	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	0.05725800478022	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: