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View Structure Prediction Details

Protein: EHT1
Organism: Saccharomyces cerevisiae
Length: 451 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EHT1.

Description E-value Query
Range
Subject
Range
gi|4586632 - gi|4586632|dbj|BAA76441.1| alcohol acyl transferase [Saccharomyces cerevisiae]
0.0 [1..451] [1..451]
gi|15240586, gi|... - gi|8777426|dbj|BAA97016.1| unnamed protein product [Arabidopsis thaliana], gi|15240586|ref|NP_199806...
4.0E-54 [17..447] [42..410]
ABHD3_MOUSE - Phospholipase ABHD3 OS=Mus musculus GN=Abhd3 PE=1 SV=1
4.0E-52 [44..448] [65..403]
gi|18203711 - gi|18203711|gb|AAH21196.1| Abhydrolase domain containing 3 [Homo sapiens]
5.0E-50 [44..448] [65..403]

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Predicted Domain #1
Region A:
Residues: [1-109]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEVSKWPAI NPFHWGYNGT VSHIVGENGS IKLHLKDNKE QVDFDEFANK YVPTLKNGAQ  60
   61 FKLSPYLFTG ILQTLYLGAA DFSKKFPVFY GREIVKFSDG GVCTADWLI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.500 a.26.1 4-helical cytokines
View Download 0.608 f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.534 b.1.10 Clathrin adaptor appendage domain
View Download 0.576 d.189.1 PX domain
View Download 0.573 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.456 b.60.1 Lipocalins
View Download 0.436 b.60.1 Lipocalins
View Download 0.435 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.388 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.376 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.365 a.7.1 Spectrin repeat
View Download 0.365 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.362 a.118.11 Cytochrome c oxidase subunit E
View Download 0.356 a.118.1 ARM repeat
View Download 0.345 b.1.2 Fibronectin type III
View Download 0.344 d.58.48 MTH1187-like
View Download 0.335 a.61.1 Retroviral matrix proteins
View Download 0.332 a.74.1 Cyclin-like
View Download 0.322 b.60.1 Lipocalins
View Download 0.321 a.7.1 Spectrin repeat
View Download 0.321 d.141.1 Ribosomal protein L6
View Download 0.317 c.55.4 Translational machinery components
View Download 0.314 d.17.4 NTF2-like
View Download 0.311 a.118.14 FliG
View Download 0.309 b.60.1 Lipocalins
View Download 0.308 a.64.1 Saposin
View Download 0.307 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.289 d.42.1 POZ domain
View Download 0.285 b.1.2 Fibronectin type III
View Download 0.283 b.34.8 Fumarylacetoacetate hydrolase, FAH, N-terminal domain
View Download 0.271 b.1.1 Immunoglobulin
View Download 0.270 a.39.1 EF-hand
View Download 0.269 d.52.7 Ribosome-binding factor A, RbfA
View Download 0.261 c.47.1 Thioredoxin-like
View Download 0.260 a.26.1 4-helical cytokines
View Download 0.258 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.258 d.15.1 Ubiquitin-like
View Download 0.253 d.54.1 Enolase N-terminal domain-like
View Download 0.252 a.7.1 Spectrin repeat
View Download 0.252 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.237 i.1.1 Ribosome and ribosomal fragments
View Download 0.233 b.1.15 Integrin domains
View Download 0.229 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.227 a.130.1 Chorismate mutase II
View Download 0.223 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.220 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.217 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.213 d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.209 i.1.1 Ribosome and ribosomal fragments
View Download 0.205 a.118.9 ENTH/VHS domain
View Download 0.204 a.2.3 Chaperone J-domain
View Download 0.203 a.26.1 4-helical cytokines
View Download 0.203 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain

Predicted Domain #2
Region A:
Residues: [110-451]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSWKKDYEFD QSTTSFDKKK FDKDEKATHP EGWPRLQPRT RYLKDNELEE LREVDLPLVV  60
   61 ILHGLAGGSH EPIIRSLAEN LSRSGRFQVV VLNTRGCARS KITTRNLFTA YHTMDIREFL 120
  121 QREKQRHPDR KLYAVGCSFG ATMLANYLGE EGDKSPLSAA ATLCNPWDLL LSAIRMSQDW 180
  181 WSRTLFSKNI AQFLTRTVQV NMGELGVPNG SLPDHPPTVK NPSFYMFTPE NLIKAKSFKS 240
  241 TREFDEVYTA PALGFPNAME YYKAASSINR VDTIRVPTLV INSRDDPVVG PDQPYSIVEK 300
  301 NPRILYCRTD LGGHLAYLDK DNNSWATKAI AEFFTKFDEL VV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.522879
Match: 1cqzA_
Description: Epoxide hydrolase, N-terminal domain; Mammalian epoxide hydrolase, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 1.39629727416851 bayes_pls_golite062009
lipase activity 0.849473630399459 bayes_pls_golite062009
carboxylesterase activity 0.424330502936163 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.264183693934251 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle