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View Structure Prediction Details

Protein: ARA1
Organism: Saccharomyces cerevisiae
Length: 344 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARA1.

Description E-value Query
Range		 Subject
Range
gi|15208400 - gi|15208400|dbj|BAB63207.1| 3(20)alpha-hydroxysteroid/dihydrodiol/indanol dehydrogenase [Macaca fusc...
AK1C1_MACFU - Aldo-keto reductase family 1 member C1 homolog OS=Macaca fuscata fuscata GN=AKR1C1 PE=2 SV=1
gi|109088079, gi... - gi|109088083|ref|XP_001103887.1| PREDICTED: aldo-keto reductase family 1, member C1 isoform 5 [Macac...
 0.0 [20..337] [3..322]
AK1C1_MACFA - Aldo-keto reductase family 1 member C1 homolog OS=Macaca fascicularis GN=AKR1C1 PE=1 SV=1
 0.0 [20..337] [3..322]
DHB5_MOUSE - Estradiol 17 beta-dehydrogenase 5 OS=Mus musculus GN=Akr1c6 PE=1 SV=1
 0.0 [20..337] [3..322]
gi|60654665, gi|... - gi|60654667|gb|AAX31898.1| aldo-keto reductase family 1 member C1 [synthetic construct], gi|60654665...
AKR1C1 - aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxyster...
 0.0 [23..337] [6..322]
PE2R_RABIT - Prostaglandin-E(2) 9-reductase OS=Oryctolagus cuniculus GN=AKR1C5 PE=1 SV=1
 0.0 [23..337] [6..322]
PGFS1_BOVIN - Prostaglandin F synthase 1 OS=Bos taurus PE=1 SV=3
 0.0 [21..337] [4..322]

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Predicted Domain #1
Region A:
Residues: [1-240] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSVASTEN IVENMLHPKT TEIYFSLNNG VRIPALGLGT ANPHEKLAET KQAVKAAIKA  60
   61 GYRHIDTAWA YETEPFVGEA IKELLEDGSI KREDLFITTK VWPVLWDEVD RSLNESLKAL 120
  121 GLEYVDLLLQ HWPLCFEKIK DPKGISGLVK TPVDDSGKTM YAADGDYLET YKQLEKIYLD 180
  181 PNDHRVRAIG VSNFSIEYLE RLIKECRVKP TVNQVETHPH LPQMELRKFC FMHDILLTAY 240
  241

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [276-299] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IRQGTIVIPR SLNPVRISSS IEFA

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [321-344] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDEPFAAILP EFTGNGPNLD NLKY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 522.0
Match: 1llgA_
Description: No description for 1llgA_ was found.

Predicted functions:

Term Confidence Notes
aldehyde reductase activity 5.07106269693426 bayes_pls_golite062009
L-glucuronate reductase activity 4.06568552614053 bayes_pls_golite062009
arabinose reductase activity 3.28910924444005 bayes_pls_golite062009
xylose reductase activity 3.28910924444005 bayes_pls_golite062009
glucose 1-dehydrogenase (NADP+) activity 2.68048267823456 bayes_pls_golite062009
aldo-keto reductase activity 2.57303336304449 bayes_pls_golite062009
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity 2.43245618396666 bayes_pls_golite062009
3-alpha-hydroxysteroid dehydrogenase (B-specific) activity 2.43245618396666 bayes_pls_golite062009
alpha-keto ester reductase activity 2.31616201247794 bayes_pls_golite062009
alpha-keto amide reductase activity 2.31616201247794 bayes_pls_golite062009
steroid dehydrogenase activity 2.19555484888528 bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.87468990921314 bayes_pls_golite062009
catalytic activity 1.68179794468736 bayes_pls_golite062009
glucose 1-dehydrogenase activity 1.55697325009049 bayes_pls_golite062009
bile acid transmembrane transporter activity 1.47447940903315 bayes_pls_golite062009
monocarboxylic acid transmembrane transporter activity 1.45034485133104 bayes_pls_golite062009
binding 1.3044513338497 bayes_pls_golite062009
bile acid binding 1.28757511368757 bayes_pls_golite062009
transporter activity 1.24767072239634 bayes_pls_golite062009
oxidoreductase activity 1.22645031212774 bayes_pls_golite062009
organic acid transmembrane transporter activity 1.20678148401125 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 1.19919645230426 bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-CH group of donors 1.15597377782029 bayes_pls_golite062009
3-oxo-5-beta-steroid 4-dehydrogenase activity 1.15597377782029 bayes_pls_golite062009
protein binding 1.06359558718341 bayes_pls_golite062009
transmembrane transporter activity 1.03420335553507 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 0.868027162240181 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.86591084281532 bayes_pls_golite062009
substrate-specific transporter activity 0.783004917746429 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.544360068128604 bayes_pls_golite062009
ion transmembrane transporter activity 0.260605752589411 bayes_pls_golite062009
cation transmembrane transporter activity 0.0547047948210824 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [241-275] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPLGSHGAPN LKIPLVKKLA EKYNVTGNDL LISYH

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [300-320] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLTKDELQEL NDFGEKYPVR F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 522.0
Match: 1llgA_
Description: No description for 1llgA_ was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle