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View Structure Prediction Details

Protein: SUP45
Organism: Saccharomyces cerevisiae
Length: 437 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SUP45.

Description E-value Query
Range
Subject
Range
ETF1 - eukaryotic translation termination factor 1
ERF1_MOUSE - Eukaryotic peptide chain release factor subunit 1 OS=Mus musculus GN=Etf1 PE=1 SV=4
ERF1_MESAU - Eukaryotic peptide chain release factor subunit 1 OS=Mesocricetus auratus GN=ETF1 PE=1 SV=3
gi|118097222 - gi|118097222|ref|XP_414511.2| PREDICTED: similar to C11 protein [Gallus gallus]
ERF1_RABIT - Eukaryotic peptide chain release factor subunit 1 OS=Oryctolagus cuniculus GN=ETF1 PE=1 SV=3
gi|114601971, gi... - gi|114601971|ref|XP_001171542.1| PREDICTED: eukaryotic translation termination factor 1 isoform 3 [P...
gi|126290367 - gi|126290367|ref|XP_001368222.1| PREDICTED: similar to C11 protein [Monodelphis domestica]
tr|M3WU44|M3WU44... - Uncharacterized protein OS=Felis catus GN=ETF1 PE=4 SV=1
ERF1_RAT - Eukaryotic peptide chain release factor subunit 1 OS=Rattus norvegicus GN=Etf1 PE=2 SV=3
gi|73970878, gi|... - gi|73978635|ref|XP_531922.2| PREDICTED: similar to eukaryotic translation termination factor 1 (pred...
ENSCJAT00000013296 - null
gi|109078786 - gi|109078786|ref|XP_001113021.1| PREDICTED: similar to eukaryotic translation termination factor 1 (...
ERF1_BOVIN - Eukaryotic peptide chain release factor subunit 1 OS=Bos taurus GN=ETF1 PE=2 SV=3
0.0 [3..430] [6..436]
ERF1_XENLA - Eukaryotic peptide chain release factor subunit 1 OS=Xenopus laevis GN=etf1 PE=2 SV=1
0.0 [3..430] [6..436]
gi|15489222 - gi|15489222|gb|AAH13717.1| Eukaryotic translation termination factor 1 [Mus musculus]
0.0 [3..430] [6..436]
gi|220944832, gi... - gi|220954670|gb|ACL89878.1| eRF1-PA [synthetic construct], gi|220944832|gb|ACL84959.1| eRF1-PA [synt...
gi|194118161, gi... - gi|195160369|ref|XP_002021048.1| GL25132 [Drosophila persimilis], gi|194118161|gb|EDW40204.1| GL2513...
eRF1-PC, eRF1-PB... - The gene eukaryotic release factor 1 is referred to in FlyBase by the symbol Dmel\eRF1 (CG5605, FBgn...
0.0 [2..430] [5..437]
ERF1_POLMI - Eukaryotic peptide chain release factor subunit 1 OS=Polyandrocarpa misakiensis GN=ERF1 PE=2 SV=1
0.0 [2..418] [5..423]
gi|158283373, gi... - gi|18250310|gb|AAL17660.1| eukaryotic release factor 1 [Chlamydomonas reinhardtii], gi|159471451|ref...
0.0 [3..430] [5..438]
ERF1Y_ARATH - Eukaryotic peptide chain release factor subunit 1-2 OS=Arabidopsis thaliana GN=ERF1-2 PE=1 SV=1
0.0 [1..430] [1..434]
gi|85084324 - gi|85084324|ref|XP_957296.1| eukaryotic peptide chain release factor subunit 1 [Neurospora crassa OR...
gi|28918385, gi|... - gi|32403766|ref|XP_322496.1| EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1 (ERF1) (EUKARYOTIC RE...
0.0 [2..429] [5..434]
SUP45 - Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipo...
gi|207347640 - gi|207347640|gb|EDZ73746.1| YBR143Cp-like protein [Saccharomyces cerevisiae AWRI1631]
ERF1_YEAST - Eukaryotic peptide chain release factor subunit 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / ...
gi|151946533 - gi|151946533|gb|EDN64755.1| eRF1 [Saccharomyces cerevisiae YJM789]
gi|190408702 - gi|190408702|gb|EDV11967.1| eukaryotic peptide chain release factor subunit 1 [Saccharomyces cerevis...
0.0 [1..437] [1..437]

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Predicted Domain #1
Region A:
Residues: [1-10]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDNEVEKNIE 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [276-437]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KYVQEKKLLE AYFDEISQDT GKFCYGIDDT LKALDLGAVE KLIVFENLET IRYTFKDAED  60
   61 NEVIKFAEPE AKDKSFAIDK ATGQEMDVVS EEPLIEWLAA NYKNFGATLE FITDKSSEGA 120
  121 QFVTGFGGIG AMLRYKVNFE QLVDESEDEY YDEDEGSDYD FI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2710.0
Match: 1dt9A_
Description: Middle domain of eukaryotic peptide chain release factor subunit 1, ERF1; C-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1; N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
translation release factor activity 11.5102558694213 bayes_pls_golite062009
translation termination factor activity 11.4768548464911 bayes_pls_golite062009
translation release factor activity, codon specific 7.66455753522311 bayes_pls_golite062009
structural constituent of ribosome 2.97154934968642 bayes_pls_golite062009
nucleic acid binding 2.70960972397471 bayes_pls_golite062009
structural molecule activity 2.64319832043379 bayes_pls_golite062009
binding 2.24516466558786 bayes_pls_golite062009
translation regulator activity 1.83257472130927 bayes_pls_golite062009
translation factor activity, nucleic acid binding 1.81472167858216 bayes_pls_golite062009
RNA binding 1.59103459949328 bayes_pls_golite062009
mRNA binding 0.607146672130391 bayes_pls_golite062009
protein binding 0.381324299701367 bayes_pls_golite062009
catalytic activity 0.264002643439785 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [11-138]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IWKVKKLVQS LEKARGNGTS MISLVIPPKG QIPLYQKMLT DEYGTASNIK SRVNRLSVLS  60
   61 AITSTQQKLK LYNTLPKNGL VLYCGDIITE DGKEKKVTFD IEPYKPINTS LYLCDNKFHT 120
  121 EVLSELLQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2710.0
Match: 1dt9A_
Description: Middle domain of eukaryotic peptide chain release factor subunit 1, ERF1; C-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1; N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [139-275]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADDKFGFIVM DGQGTLFGSV SGNTRTVLHK FTVDLPKKHG RGGQSALRFA RLREEKRHNY  60
   61 VRKVAEVAVQ NFITNDKVNV KGLILAGSAD FKTDLAKSEL FDPRLACKVI SIVDVSYGGE 120
  121 NGFNQAIELS AEALANV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2710.0
Match: 1dt9A_
Description: Middle domain of eukaryotic peptide chain release factor subunit 1, ERF1; C-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1; N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle