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View Structure Prediction Details

Protein: TPS1
Organism: Saccharomyces cerevisiae
Length: 495 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TPS1.

Description E-value Query
Range
Subject
Range
gi|3540 - gi|3540|emb|CAA43580.1| cif1 [Saccharomyces cerevisiae]
0.0 [1..495] [1..495]
TPS1_KLULA - Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit OS=Kluyveromyces lactis GN=TPS...
TPS1_KLULA - Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit OS=Kluyveromyces lactis (strai...
0.0 [3..487] [2..487]
TPSB_ASPNG - Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2 OS=Aspergillus niger GN=tpsB PE=3 SV=1
gi|145238596 - gi|145238596|ref|XP_001391945.1| alpha, alpha-trehalose-phosphate synthase (UDP-forming) 2 (trehalos...
0.0 [10..482] [6..477]
TPS1_ZYGRO - Alpha,alpha-trehalose-phosphate synthase [UDP-forming] OS=Zygosaccharomyces rouxii GN=TPS1 PE=2 SV=1
0.0 [1..481] [1..476]
TPS1_SCHPO - Alpha,alpha-trehalose-phosphate synthase [UDP-forming] OS=Schizosaccharomyces pombe (strain 972 / AT...
tps1 - alpha,alpha-trehalose-phosphate synthase [UDP-forming]
0.0 [11..483] [14..484]
TPS1_EMENI - Alpha,alpha-trehalose-phosphate synthase [UDP-forming] OS=Emericella nidulans GN=tpsA PE=3 SV=1
TPS1_EMENI - Alpha,alpha-trehalose-phosphate synthase [UDP-forming] OS=Emericella nidulans (strain FGSC A4 / ATCC...
0.0 [9..494] [5..488]
TPS1_YARLI - Alpha,alpha-trehalose-phosphate synthase [UDP-forming] OS=Yarrowia lipolytica GN=TPS1 PE=2 SV=1
TPS1_YARLI - Alpha,alpha-trehalose-phosphate synthase [UDP-forming] OS=Yarrowia lipolytica (strain CLIB 122 / E 1...
0.0 [15..482] [1..468]

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Predicted Domain #1
Region A:
Residues: [1-115]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTDNAKAQL TSSSGGNIIV VSNRLPVTIT KNSSTGQYEY AMSSGGLVTA LEGLKKTYTF  60
   61 KWFGWPGLEI PDDEKDQVRK DLLEKFNAVP IFLSDEIADL HYNGFSNSIL WPLFH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.646 0.349 carbohydrate metabolic process c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.398 0.142 cytoplasm b.55.1 PH domain-like
View Download 0.491 N/A N/A d.58.11 EF-G/eEF-2 domains III and V
View Download 0.395 N/A N/A c.25.1 Ferredoxin reductase-like, C-terminal NADP-linked domain
View Download 0.372 N/A N/A c.23.13 Type II 3-dehydroquinate dehydratase
View Download 0.350 N/A N/A c.78.1 Aspartate/ornithine carbamoyltransferase
View Download 0.349 N/A N/A b.33.1 ISP domain
View Download 0.347 N/A N/A b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.335 N/A N/A c.26.3 UDP-glucose/GDP-mannose dehydrogenase C-terminal domain
View Download 0.335 N/A N/A d.129.1 TATA-box binding protein-like
View Download 0.335 N/A N/A c.49.1 Pyruvate kinase, C-terminal domain
View Download 0.330 N/A N/A c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.305 N/A N/A c.3.1 FAD/NAD(P)-binding domain
View Download 0.286 N/A N/A d.15.2 CAD & PB1 domains
View Download 0.279 N/A N/A d.95.2 Homing endonucleases
View Download 0.261 N/A N/A d.206.1 YggU-like
View Download 0.247 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.245 N/A N/A d.58.17 Metal-binding domain
View Download 0.240 N/A N/A c.3.1 FAD/NAD(P)-binding domain
View Download 0.240 N/A N/A c.44.2 Enzyme IIB-cellobiose
View Download 0.237 N/A N/A c.55.3 Ribonuclease H-like
View Download 0.224 N/A N/A d.12.1 Ribosomal proteins L23 and L15e
View Download 0.222 N/A N/A c.23.1 CheY-like
View Download 0.221 N/A N/A b.11.1 gamma-Crystallin-like
View Download 0.216 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.209 N/A N/A d.19.1 MHC antigen-recognition domain
View Download 0.209 N/A N/A c.66.1 S-adenosyl-L-methionine-dependent methyltransferases
View Download 0.208 N/A N/A c.55.7 Methylated DNA-protein cysteine methyltransferase domain

Predicted functions:

Term Confidence Notes
alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity 11.2045941324603 bayes_pls_golite062009
glucosyltransferase activity 8.25064561355471 bayes_pls_golite062009
UDP-glucosyltransferase activity 8.0463972704113 bayes_pls_golite062009
trehalose-phosphatase activity 7.58500038184065 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 3.70184884300914 bayes_pls_golite062009
catalytic activity 2.65148466065976 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 2.62403914335522 bayes_pls_golite062009
transferase activity 2.18054407163329 bayes_pls_golite062009
UDP-glycosyltransferase activity 2.13085705769565 bayes_pls_golite062009
UDP-N-acetylglucosamine 2-epimerase activity 1.55280519670033 bayes_pls_golite062009
carbohydrate phosphatase activity 0.78952375993773 bayes_pls_golite062009
glycogen phosphorylase activity 0.607220464589157 bayes_pls_golite062009
binding 0.345236672370351 bayes_pls_golite062009
phosphorylase activity 0.296436712681472 bayes_pls_golite062009
mannosyltransferase activity 0.253888301381021 bayes_pls_golite062009
protein binding 0.198267161626932 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [116-263]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YHPGEINFDE NAWLAYNEAN QTFTNEIAKT MNHNDLIWVH DYHLMLVPEM LRVKIHEKQL  60
   61 QNVKVGWFLH TPFPSSEIYR ILPVRQEILK GVLSCDLVGF HTYDYARHFL SSVQRVLNVN 120
  121 TLPNGVEYQG RFVNVGAFPI GIDVDKFT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [463-495]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YISKYTSAFW GENFVHELYS TSSSSTSSSA TKN

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.21
Match: 1f6dA
Description: UDP-N-acetylglucosamine 2-epimerase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [264-462]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGLKKESVQK RIQQLKETFK GCKIIVGVDR LDYIKGVPQK LHAMEVFLNE HPEWRGKVVL  60
   61 VQVAVPSRGD VEEYQYLRSV VNELVGRING QFGTVEFVPI HFMHKSIPFE ELISLYAVSD 120
  121 VCLVSSTRDG MNLVSYEYIA CQEEKKGSLI LSEFTGAAQS LNGAIIVNPW NTDDLSDAIN 180
  181 EALTLPDVKK EVNWEKLYK

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.21
Match: 1f6dA
Description: UDP-N-acetylglucosamine 2-epimerase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle