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View Structure Prediction Details

Protein: REB1
Organism: Saccharomyces cerevisiae
Length: 810 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for REB1.

Description E-value Query
Range
Subject
Range
REB1 - RNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by b...
REB1_YEAST - DNA-binding protein REB1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=REB1 PE=1 SV=2
gi|190408787 - gi|190408787|gb|EDV12052.1| RNA polymerase I enhancer binding protein [Saccharomyces cerevisiae RM11...
0.0 [1..810] [1..810]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-85 [6..419] [98..529]
gi|15212037 - gi|15212037|emb|CAC51118.1| putative bifunctional autolysin [Staphylococcus xylosus]
2.0E-68 [7..419] [195..620]
reb1 - RNA polymerase I transcription termination factor Reb1
REB1_SCHPO - DNA-binding protein reb1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=reb1 PE=3 SV=1
5.0E-66 [191..553] [22..391]
gi|18413894, gi|... - gi|41619514|gb|AAS10119.1| MYB transcription factor [Arabidopsis thaliana], gi|18413894|ref|NP_56809...
4.0E-65 [341..636] [3..294]

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Predicted Domain #1
Region A:
Residues: [1-248]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSGHNDKNA NQESVEEAVL KYVGVGLDHQ NHDPQLHTKD LENKHSKKQN IVESSSDVDV  60
   61 NNNDDSNRNE DNNDDSENIS ALNANESSSN VDHANSNEQH NAVMDWYLRQ TAHNQQDDED 120
  121 DENNNNTDNG NDSNNHFSQS DIVVDDDDDK NKKDAGVGVD DDHQSMAMAA VAAAYTLSKN 180
  181 NNNNNSIAND SNSRKRQHDN GNNHENSQKK RKNNNDDDDR QIGNVDPELT TLGDADDNDT 240
  241 NNDVIDRD

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.26
Match: 1ldvA
Description: No description for 1ldvA was found.

Predicted Domain #2
Region A:
Residues: [249-373]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLVHKAIIDA DSITQHPDFQ QYLNTAADTD DNEKLKHIKD HLMRTHGLNH QNKNHNDDTD  60
   61 DLSNSTKQYS ELQKDSMLDS SLNKSRNYME VLPKVISQDT QPHQQKSPSH DNEAGSVDNS 120
  121 EISQL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.201 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.275 a.118.8 TPR-like
View Download 0.219 a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.299 a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain

Predicted Domain #3
Region A:
Residues: [374-472]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQSAATKASS LVSLSSSSAT PSTSRSNNSK AFDKAEDAAL ERFINEYEAI ERLTRQQVCE  60
   61 RIWSSDRPKD NFWNNIYKVL PYRSSSSIYK HMRRKYHIF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 89.9897
Match: 1h88C_
Description: c-Myb, DNA-binding domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.334577365229545 bayes_pls_golite062009
transcription regulator activity 0.0696342306231097 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [473-522]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EQRGKWTAEE EQELAKLCAE KEGQWAEIGK TLGRMPEDCR DRWRNYVKCG 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 89.9897
Match: 1h88C_
Description: c-Myb, DNA-binding domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [523-580]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNRASNRWSV EEEELLKKVI SDMLEEAQQQ QSQLHPNLLE EEQHLLQDDQ NDHRNNDE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 89.9897
Match: 1h88C_
Description: c-Myb, DNA-binding domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.232528774113254 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [581-657]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDDDTASAAA AAAAAIQEQQ QLLQQKQQDD DDAIAAAAAA ASSSLGDNKD EDKPHDSLGI  60
   61 QLDDNSQNSM VPAPSAT

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.4
Match: 1h88C
Description: c-Myb, DNA-binding domain
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [658-720]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STHSKSLSNT IRRHNNKLRK SLMGNGKLDF KDIINWTIVS ERMGGTRSRI QCRYKWNKLV  60
   61 KRE

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.4
Match: 1h88C
Description: c-Myb, DNA-binding domain
Matching Structure (courtesy of the PDB):

Predicted Domain #8
Region A:
Residues: [721-810]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AIAKIQTVKD DDMLWIFEKL RDLGITEDSQ VDWDELAALK PGMKLNGLEL KLCYERMKKK  60
   61 VKGYKQKSIN EISKELVDYF SSNISMKTEN 

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.4
Match: 1h88C
Description: c-Myb, DNA-binding domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle