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View Structure Prediction Details

Protein: QDR3
Organism: Saccharomyces cerevisiae
Length: 689 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for QDR3.

Description E-value Query
Range
Subject
Range
QDR3 - Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ba...
0.0 [1..689] [1..689]
gi|21225257, gi|... - gi|7649556|emb|CAB89031.1| putative membrane transport protein. [Streptomyces coelicolor A3(2)], gi|...
2.0E-62 [67..593] [1..509]
gi|15927932, gi|... - gi|15927932|ref|NP_375465.1| hypothetical protein SA2142 [Staphylococcus aureus subsp. aureus N315],...
gi|253314692 - gi|253314692|ref|ZP_04837905.1| hypothetical protein SauraC_00665 [Staphylococcus aureus subsp. aure...
gi|12003106, gi|... - pir||C90035 hypothetical protein SA2142 [imported] - Staphylococcus aureus (strain N315), gi|120031...
gi|255007128 - gi|255007128|ref|ZP_05145729.2| hypothetical protein SauraM_11685 [Staphylococcus aureus subsp. aure...
gi|14248126, gi|... - gi|15925342|ref|NP_372876.1| multidrug resistance protein [Staphylococcus aureus subsp. aureus Mu50]...
gi|269203983|ref... - EmrB/QacA family drug resistance transporter [Staphylococcus aureus subsp. aureus ED98]
gi|90583610, gi|... - gi|90583610|ref|ZP_01239364.1| Drug resistance transporter EmrB/QacA subfamily [Staphylococcus aureu...
gi|147741858, gi... - gi|90585929|ref|ZP_01241634.1| Drug resistance transporter EmrB/QacA subfamily [Staphylococcus aureu...
gi|156980667, gi... - gi|156980667|ref|YP_001442926.1| hypothetical protein SAHV_2336 [Staphylococcus aureus subsp. aureus...
2.0E-62 [2..397] [44..428]
YCT4_SCHPO - Uncharacterized transporter C794.04c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC7...
SPCC794.04c - membrane transporter
3.0E-61 [196..682] [108..544]
gi|5420310 - gi|5420310|emb|CAB46647.1| putative multiple drug resistance protein [Penicillium olsonii]
2.0E-60 [192..686] [85..535]
gi|13702155, gi|... - gi|13702161|dbj|BAB43818.1| CaNAG4 [Candida albicans], gi|13702155|dbj|BAB43815.1| CaNAG4 [Candida a...
gi|238882925 - gi|238882925|gb|EEQ46563.1| hypothetical protein CAWG_04919 [Candida albicans WO-1]
2.0E-57 [211..682] [142..573]

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Predicted Domain #1
Region A:
Residues: [1-70]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQAQGSQSNV GSLRSNCSDN SLPNNHVMMH CDESSGTPHS EHNDYSYEKT NLESTASNSR  60
   61 EHRDNQLSRL 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.508 a.60.11 Hypothetical protein YjbJ
View Download 0.478 a.60.12 DNA polymerase beta-like, second domain
View Download 0.461 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.284 a.5.2 UBA-like
View Download 0.267 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.260 f.14.1 Voltage-gated potassium channels
View Download 0.222 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.218 d.58.12 eEF-1beta-like
View Download 0.216 a.118.11 Cytochrome c oxidase subunit E
View Download 0.209 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1

Predicted Domain #2
Region A:
Residues: [71-281]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSEEYVVPKN QRRGLLPQLA IIPEFKDARD YPPMMKKMIV FLIAFSSMMG PMGTSIIFPA  60
   61 INSITTEFKT SVIMVNVSIG VYLLSLGVFP LWWSSLSELE GRRTTYITSF ALLFAFNIGS 120
  121 ALAPDINSFI ALRMLCGAAS ASVQSVGAGT VADLYISEDR GKNLSYYYLG PLLAPLLSPI 180
  181 FGSLLVNRWP WRSTQWFMVI LSGCNVILLT V

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [323-547]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDETDRIENQ VATLSTEKHN YVGEVRDQDS LDLESHSSPN TYDGRAGETQ LQRIYTEASR  60
   61 SLYEYQLDDS GIDATTAQVT RIRSTDPKLA RSIRENSLRK LQTNLEEQVK KVLSSNGGEI 120
  121 APKQVSAVRK VWDTFFVYFI KPLKSLHFLE YPPVALAITF SAISFSTVYF VNMTVEYKYS 180
  181 RPPYNFKPLY IGLLYIPNSV TYFFASIYGG RWVDMLLKRY KEKYG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.30103
Match: 1ja5A_
Description: No description for 1ja5A_ was found.

Predicted Domain #3
Region A:
Residues: [282-322]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLPETLRKQD SKGAIAQILA ERRIQVDNNE RGEIQEDYQR G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.30103
Match: 1ja5A_
Description: No description for 1ja5A_ was found.

Predicted Domain #4
Region A:
Residues: [548-689]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ILAPEARISW NVVTSVISFP IALLIFGWCL DKKCHWVTPL IGTALFGYAA MMTIGATLSY  60
   61 LVDSLPGKGA TGVALNNLIR QILAATAVFV TTPMLNGMGT GWAFTMLAFI VLGASSVLII 120
  121 LKKHGDYWRE NYDLQKLYDK ID

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.669 f.14.1 Voltage-gated potassium channels
View Download 0.659 a.19.1 Fertilization protein
View Download 0.657 a.24.3 Cytochromes
View Download 0.647 a.149.1 RNase III endonuclease catalytic domain
View Download 0.638 a.25.1 Ferritin-like
View Download 0.638 a.26.1 4-helical cytokines
View Download 0.625 f.18.1 F1F0 ATP synthase subunit A
View Download 0.618 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.611 a.62.1 Hepatitis B viral capsid (hbcag)
View Download 0.594 a.47.2 t-snare proteins
View Download 0.587 a.7.8 GAT domain
View Download 0.579 a.7.4 Smac/diablo
View Download 0.577 a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.575 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.574 a.22.1 Histone-fold
View Download 0.573 a.24.14 FAT domain of focal adhesion kinase
View Download 0.573 a.133.1 Phospholipase A2, PLA2
View Download 0.570 a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.565 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.549 f.35.1 Multidrug efflux transporter AcrB transmembrane domain
View Download 0.541 a.24.3 Cytochromes
View Download 0.538 a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.523 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.513 f.32.1 a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.505 i.11.1 Computational models partly based on NMR data
View Download 0.501 a.24.9 alpha-catenin/vinculin
View Download 0.497 a.149.1 RNase III endonuclease catalytic domain
View Download 0.484 a.19.1 Fertilization protein
View Download 0.483 d.173.1 Methionine synthase activation domain-like
View Download 0.475 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.472 f.15.1 Small-conductance potassium channel
View Download 0.465 f.31.1 Photosystem I reaction center subunit XI, PsaL
View Download 0.452 a.24.1 Apolipoprotein
View Download 0.449 a.24.9 alpha-catenin/vinculin
View Download 0.449 a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.439 a.24.9 alpha-catenin/vinculin
View Download 0.438 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.430 a.22.1 Histone-fold
View Download 0.390 a.118.1 ARM repeat
View Download 0.377 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.376 a.63.1 Apolipophorin-III
View Download 0.375 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.374 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.371 a.87.1 DBL homology domain (DH-domain)
View Download 0.370 a.167.1 Porin chaperone SurA, peptide-binding domain
View Download 0.368 f.25.1 Cytochrome c oxidase subunit III-like
View Download 0.360 a.25.1 Ferritin-like
View Download 0.349 a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.324 a.47.2 t-snare proteins
View Download 0.323 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.319 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.315 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.314 a.1.1 Globin-like
View Download 0.311 a.26.1 4-helical cytokines
View Download 0.310 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.302 a.48.1 N-terminal domain of cbl (N-cbl)
View Download 0.302 f.13.1 Family A G protein-coupled receptor-like
View Download 0.293 f.1.3 delta-Endotoxin (insectocide), N-terminal domain
View Download 0.293 a.74.1 Cyclin-like
View Download 0.285 c.23.5 Flavoproteins
View Download 0.282 d.91.1 N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
View Download 0.275 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.269 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.264 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.262 f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.260 a.26.1 4-helical cytokines
View Download 0.254 a.7.7 BAG domain
View Download 0.249 a.26.1 4-helical cytokines
View Download 0.249 a.47.2 t-snare proteins
View Download 0.248 a.75.1 Ribosomal protein S7
View Download 0.248 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.247 a.26.1 4-helical cytokines
View Download 0.245 c.55.1 Actin-like ATPase domain
View Download 0.245 a.182.1 GatB/YqeY domain
View Download 0.241 a.128.1 Terpenoid synthases
View Download 0.238 i.1.1 Ribosome and ribosomal fragments
View Download 0.236 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.236 a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.233 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.232 f.1.3 delta-Endotoxin (insectocide), N-terminal domain
View Download 0.226 a.40.1 Calponin-homology domain, CH-domain
View Download 0.224 a.7.1 Spectrin repeat
View Download 0.224 a.1.1 Globin-like
View Download 0.221 a.74.1 Cyclin-like
View Download 0.214 d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.214 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.212 a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.211 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.210 a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.209 a.7.5 Tubulin chaperone cofactor A
View Download 0.206 c.95.1 Thiolase-like
View Download 0.205 a.24.9 alpha-catenin/vinculin
View Download 0.204 a.1.1 Globin-like
View Download 0.203 a.48.2 Transferrin receptor ectodomain, C-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle