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View Structure Prediction Details

Protein: RKM3
Organism: Saccharomyces cerevisiae
Length: 552 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RKM3.

Description E-value Query
Range
Subject
Range
RKM3_YEAST - Ribosomal lysine N-methyltransferase 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=R...
RKM3 - Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); ...
0.0 [1..552] [1..552]
RBCMT_ARATH - [Fructose-bisphosphate aldolase]-lysine N-methyltransferase, chloroplastic OS=Arabidopsis thaliana G...
4.0E-66 [1..327] [38..348]
SETD4 - SET domain containing 4
3.0E-64 [12..387] [36..333]
RBCMT_TOBAC - Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic OS=...
3.0E-63 [11..325] [56..355]
SETD4_MOUSE - SET domain-containing protein 4 OS=Mus musculus GN=Setd4 PE=2 SV=1
4.0E-63 [12..302] [35..302]
RBCMT_PEA - Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic OS=...
3.0E-62 [11..327] [53..354]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-61 [12..327] [56..356]

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Predicted Domain #1
Region A:
Residues: [1-295]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVTFKDDVH RILKFVANCN GRFEDSKCDI RESPLGGLGV FAKTDIAEGE SILTLNKSSI  60
   61 FSASNSSIAN LLCDSSIDGM LALNIAFIYE TTVFRNSSHW YPFLRTIRIR DDEGHLNLPP 120
  121 SFWHADAKRL LKGTSFDTLF DSLAPEEEIM EGFEIAVDLA HKWNDEFGLE IPKGFLDVSE 180
  181 ENHEEDYNLK LEKFISVAYT LSSRGFEIDA YHETALVPIA DLFNHHVSDP DLKFVSLYDV 240
  241 CDKCGEPDMC KHLIAEEYLE AENLDKNMPK VASMETRVID EDLIKSLEND LEKEY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
histone methyltransferase activity 6.20878333364554 bayes_pls_golite062009
protein methyltransferase activity 6.08778683840554 bayes_pls_golite062009
lysine N-methyltransferase activity 5.45106430536252 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 5.45106430536252 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 5.45106430536252 bayes_pls_golite062009
N-methyltransferase activity 3.98411678860954 bayes_pls_golite062009
histone methyltransferase activity (H3-K9 specific) 3.54138873512018 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 2.69428385009711 bayes_pls_golite062009
methyltransferase activity 2.33114816345072 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 2.25175257044903 bayes_pls_golite062009
binding 1.67469558504376 bayes_pls_golite062009
nucleic acid binding 1.29511015534184 bayes_pls_golite062009
protein binding 1.07532079834012 bayes_pls_golite062009
transferase activity 0.653108419761009 bayes_pls_golite062009
chromatin binding 0.628375771647179 bayes_pls_golite062009
catalytic activity 0.414641636618101 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [296-399]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNVTANIEDD DGGIENPDEC VDLVLKNDVA QGQEIFNSYG ELSNVFLLAR YGFTVPENQY  60
   61 DIVHLGPDFM KILKKEEKYQ EKVKWWSQVG HGLFSAWYAQ MRQE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.422 0.277 phospholipid metabolic process a.1.1 Globin-like
View Download 0.319 0.027 phospholipid metabolic process a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.492 0.014 phospholipid metabolic process a.60.9 lambda integrase-like, N-terminal domain
View Download 0.338 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.299 N/A N/A a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.295 N/A N/A a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.283 N/A N/A a.29.4 RecG, N-terminal domain
View Download 0.268 N/A N/A d.8.1 Urease, gamma-subunit
View Download 0.267 N/A N/A a.4.3 ARID-like
View Download 0.263 N/A N/A a.72.1 Functional domain of the splicing factor Prp18
View Download 0.261 N/A N/A a.7.8 GAT domain
View Download 0.255 N/A N/A a.60.13 Putative methyltransferase TM0872, insert domain
View Download 0.248 N/A N/A d.54.1 Enolase N-terminal domain-like
View Download 0.247 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.246 N/A N/A d.50.1 dsRNA-binding domain-like
View Download 0.240 N/A N/A a.3.1 Cytochrome c
View Download 0.234 N/A N/A a.118.1 ARM repeat
View Download 0.233 N/A N/A d.15.6 Superantigen toxins, C-terminal domain
View Download 0.232 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.232 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.230 N/A N/A d.204.1 Ribosome binding protein Y (YfiA homologue)
View Download 0.229 N/A N/A a.69.1 C-terminal domain of alpha and beta subunits of F1 ATP synthase
View Download 0.224 N/A N/A a.1.1 Globin-like
View Download 0.224 N/A N/A d.58.4 Dimeric alpha+beta barrel
View Download 0.223 N/A N/A a.159.2 FF domain
View Download 0.222 N/A N/A a.39.1 EF-hand
View Download 0.222 N/A N/A a.3.1 Cytochrome c
View Download 0.218 N/A N/A a.47.2 t-snare proteins
View Download 0.216 N/A N/A a.46.1 Methionine synthase domain
View Download 0.214 N/A N/A a.29.2 Bromodomain
View Download 0.214 N/A N/A a.7.1 Spectrin repeat
View Download 0.213 N/A N/A a.48.2 Transferrin receptor ectodomain, C-terminal domain
View Download 0.206 N/A N/A a.118.11 Cytochrome c oxidase subunit E
View Download 0.203 N/A N/A a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.203 N/A N/A c.55.3 Ribonuclease H-like
View Download 0.203 N/A N/A a.130.1 Chorismate mutase II
View Download 0.202 N/A N/A a.118.1 ARM repeat
View Download 0.200 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain

Predicted Domain #3
Region A:
Residues: [400-552]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEEDEDGQAK SDNLSDDIES EEEEEEEEGD DSLESWLSQL YIDSSGEPSP STWALANLLT  60
   61 LTAVQWESLF SKKATPHISD SIVNEEKLPF LAKKDNPHSK KLLSNLLKEK QLPCIKGDNS 120
  121 SKITSATKSM LQNARTLVQS EHNILDRCLK RLS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.265 a.4.1 Homeodomain-like
View Download 0.222 a.25.1 Ferritin-like
View Download 0.263 a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.240 f.14.1 Voltage-gated potassium channels
View Download 0.456 a.19.1 Fertilization protein
View Download 0.207 d.56.1 GroEL-intermediate domain like
View Download 0.201 a.24.16 Nucleotidyltransferase substrate binding subunit/domain


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