YRC Public Data Repository - Protein Structure Prediction

Protein:	YEL1
Organism:	Saccharomyces cerevisiae
Length:	687 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YEL1.

Description	E-value	Query Range	Subject Range
YEL1 - Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required f... YEL1_YEAS7 - Guanine-nucleotide exchange factor YEL1 OS=Saccharomyces cerevisiae (strain YJM789) GN=YEL1 PE=3 SV=... YEL1_YEAST - Guanine-nucleotide exchange factor YEL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=... YEL1_YEAS8 - Guanine-nucleotide exchange factor YEL1 OS=Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de...	0.0	[1..687]	[1..687]
BIG3_ARATH - Brefeldin A-inhibited guanine nucleotide-exchange protein 3 OS=Arabidopsis thaliana GN=BIG3 PE=1 SV=...	7.0E-75	[43..333]	[585..857]
gi\|225000702 - gi\|225000702\|gb\|AAI72243.1\| ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A... ARFGEF1 - ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)	9.0E-75	[32..340]	[627..951]
BIG1_BOVIN - Brefeldin A-inhibited guanine nucleotide-exchange protein 1 OS=Bos taurus GN=ARFGEF1 PE=1 SV=1	4.0E-74	[32..340]	[627..951]
sec71 - Sec7 domain SEC7A_SCHPO - Protein transport protein sec71 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=sec71 PE=1...	3.0E-66	[9..354]	[644..956]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	5.0E-66	[9..354]	[644..956]

Back

Predicted Domain #1

Region A:
Residues: [1-64]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCASLNEVKK NDTYGVSQKG YNDNFSESEG VLHGSKSMPT SMKNMLQSPT MVNMCDILQN  60
   61 KEAA

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
ARF guanyl-nucleotide exchange factor activity	2.15082391847379	bayes_pls_golite062009
enzyme regulator activity	1.95409587538646	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	1.91412378174324	bayes_pls_golite062009
GTPase regulator activity	1.88151514457186	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	1.71252280948806	bayes_pls_golite062009
small GTPase regulator activity	1.48167884428561	bayes_pls_golite062009
protein binding	1.10832780583804	bayes_pls_golite062009
binding	0.820589177796715	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [65-127]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDEKPVIPTT DTATAGTGTE DISSTQSEET DQNSHLIASE ILEGTFKDVS YKEYANFLGN  60
   61 DNN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	108.9897
Match:	1bc9__
Description:	Cytohesin-1/b2-1
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [128-289]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NQVLTEFVKL LSPLPSSLLE TLFNLSKSIY FIAEAQNIDR ILECLSIEWI ACHPNTHWKS  60
   61 GYKSCHIVLF SLLILNSDLH NNFQVDHKKI KFSMVAFINN TLRALREENE YEELKIYSRE 120
  121 HLIIEELSEY YKTLNETPLP LCTESRTSIN ISDNQSSLKR FS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	108.9897
Match:	1bc9__
Description:	Cytohesin-1/b2-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein binding	2.35604024172114	bayes_pls_golite062009
binding	2.07235282758468	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [290-510]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLGSREFSTS NLRSVNSNST TLYSRDGQVS VREMSAKSNK NFHNNHPMDA LYLKESFDDG  60
   61 LITENGSSWF MDDLILISKK SLPRKYSKRD KDQVAAPKMT SKRNKSFFGW LKPSKTTTLI 120
  121 EHTSRRTSLS YLNKDSEWER VKIQVKEGRI FIFKIKPDVK DIIQSSETDS ATIDYFKDIS 180
  181 SSYFAYSLLE AEAHVVQDNI IIGSGAMKSN VCNKNTKRKS G

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [511-687]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFTVSFPENI NGPKLVLEFQ TRSVEEAHKF MDCINFWAGR ISPVPLTQFE AVSNAEYGWS  60
   61 DKILTEHASL NLKNIVVSEW KPLLGLELLY EDAKDVEMVE LKERLKELMN FTRQLGIWID 120
  121 KHNEIKDKLV EIWSFDDNYF EAVMNNWNSR YLYMNNQYKK RLSYLKALQK AMGSVQF

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: