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View Structure Prediction Details

Protein: YEL1
Organism: Saccharomyces cerevisiae
Length: 687 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YEL1.

Description E-value Query
Range
Subject
Range
YEL1 - Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required f...
YEL1_YEAS7 - Guanine-nucleotide exchange factor YEL1 OS=Saccharomyces cerevisiae (strain YJM789) GN=YEL1 PE=3 SV=...
YEL1_YEAST - Guanine-nucleotide exchange factor YEL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
YEL1_YEAS8 - Guanine-nucleotide exchange factor YEL1 OS=Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de...
0.0 [1..687] [1..687]
BIG3_ARATH - Brefeldin A-inhibited guanine nucleotide-exchange protein 3 OS=Arabidopsis thaliana GN=BIG3 PE=1 SV=...
7.0E-75 [43..333] [585..857]
gi|225000702 - gi|225000702|gb|AAI72243.1| ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A...
ARFGEF1 - ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
9.0E-75 [32..340] [627..951]
BIG1_BOVIN - Brefeldin A-inhibited guanine nucleotide-exchange protein 1 OS=Bos taurus GN=ARFGEF1 PE=1 SV=1
4.0E-74 [32..340] [627..951]
sec71 - Sec7 domain
SEC7A_SCHPO - Protein transport protein sec71 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=sec71 PE=1...
3.0E-66 [9..354] [644..956]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
5.0E-66 [9..354] [644..956]

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Predicted Domain #1
Region A:
Residues: [1-64]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCASLNEVKK NDTYGVSQKG YNDNFSESEG VLHGSKSMPT SMKNMLQSPT MVNMCDILQN  60
   61 KEAA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.754 a.3.1 Cytochrome c
View Download 0.491 a.4.1 Homeodomain-like
View Download 0.408 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.450 a.64.1 Saposin
View Download 0.377 a.144.1 PABC (PABP) domain
View Download 0.370 d.48.1 RecA protein, C-terminal domain
View Download 0.350 a.4.1 Homeodomain-like
View Download 0.317 a.4.5 "Winged helix" DNA-binding domain
View Download 0.274 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.266 a.4.5 "Winged helix" DNA-binding domain
View Download 0.259 a.6.1 Putative DNA-binding domain
View Download 0.255 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.248 d.52.5 Probable GTPase Der, C-terminal domain
View Download 0.234 a.3.1 Cytochrome c
View Download 0.230 a.3.1 Cytochrome c
View Download 0.223 a.109.1 Class II MHC-associated invariant chain ectoplasmic trimerization domain
View Download 0.219 a.36.1 Signal peptide-binding domain

Predicted functions:

Term Confidence Notes
ARF guanyl-nucleotide exchange factor activity 2.15082391847379 bayes_pls_golite062009
enzyme regulator activity 1.95409587538646 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.91412378174324 bayes_pls_golite062009
GTPase regulator activity 1.88151514457186 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 1.71252280948806 bayes_pls_golite062009
small GTPase regulator activity 1.48167884428561 bayes_pls_golite062009
protein binding 1.10832780583804 bayes_pls_golite062009
binding 0.820589177796715 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [65-127]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDEKPVIPTT DTATAGTGTE DISSTQSEET DQNSHLIASE ILEGTFKDVS YKEYANFLGN  60
   61 DNN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 108.9897
Match: 1bc9__
Description: Cytohesin-1/b2-1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [128-289]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NQVLTEFVKL LSPLPSSLLE TLFNLSKSIY FIAEAQNIDR ILECLSIEWI ACHPNTHWKS  60
   61 GYKSCHIVLF SLLILNSDLH NNFQVDHKKI KFSMVAFINN TLRALREENE YEELKIYSRE 120
  121 HLIIEELSEY YKTLNETPLP LCTESRTSIN ISDNQSSLKR FS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 108.9897
Match: 1bc9__
Description: Cytohesin-1/b2-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.35604024172114 bayes_pls_golite062009
binding 2.07235282758468 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [290-510]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLGSREFSTS NLRSVNSNST TLYSRDGQVS VREMSAKSNK NFHNNHPMDA LYLKESFDDG  60
   61 LITENGSSWF MDDLILISKK SLPRKYSKRD KDQVAAPKMT SKRNKSFFGW LKPSKTTTLI 120
  121 EHTSRRTSLS YLNKDSEWER VKIQVKEGRI FIFKIKPDVK DIIQSSETDS ATIDYFKDIS 180
  181 SSYFAYSLLE AEAHVVQDNI IIGSGAMKSN VCNKNTKRKS G

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [511-687]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFTVSFPENI NGPKLVLEFQ TRSVEEAHKF MDCINFWAGR ISPVPLTQFE AVSNAEYGWS  60
   61 DKILTEHASL NLKNIVVSEW KPLLGLELLY EDAKDVEMVE LKERLKELMN FTRQLGIWID 120
  121 KHNEIKDKLV EIWSFDDNYF EAVMNNWNSR YLYMNNQYKK RLSYLKALQK AMGSVQF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle