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View Structure Prediction Details

Protein: PTH2
Organism: Saccharomyces cerevisiae
Length: 214 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PTH2.

Description E-value Query
Range
Subject
Range
PTH2 - One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates ...
4.0E-70 [1..214] [1..214]
ENSPTRT00000017368 - null
PTRH2 - peptidyl-tRNA hydrolase 2
gi|190690369, gi... - gi|190691749|gb|ACE87649.1| peptidyl-tRNA hydrolase 2 protein [synthetic construct], gi|190690369|gb...
9.0E-57 [13..214] [3..179]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
4.0E-56 [14..214] [1..176]
gi|9438135 - gi|9438135|gb|AAF87580.1|AF275673_1 unknown [Ochlerotatus triseriatus]
9.0E-49 [24..213] [12..173]
SPAC19A8.14 - aminoacyl-tRNA hydrolase
PTH2_SCHPO - Probable peptidyl-tRNA hydrolase 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC19A...
4.0E-48 [14..214] [6..205]
gi|98960911, gi|... - gi|98960911|gb|ABF58939.1| At5g16870 [Arabidopsis thaliana], gi|18418110|ref|NP_568340.1| aminoacyl-...
2.0E-47 [21..213] [5..168]
gi|8248747, gi|2... - gi|8248747|emb|CAB62849.2| Peptidyl-tRNA hydrolase PTH2, putative [Plasmodium falciparum 3D7], gi|23...
3.0E-46 [27..213] [19..188]

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Predicted Domain #1
Region A:
Residues: [1-89]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITSFLMEKM TVSSNYTIAL WATFTAISFA VGYQLGTSNA SSTKKSSATL LRSKEMKEGK  60
   61 LHNDTDEEES ESEDESDEDE DIESTSLND

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [90-214]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPGEVRMALV IRQDLGMTKG KIAAQCCHAA LSCFRHIATN PARASYNPIM TQRWLNAGQA  60
   61 KITLKCPDKF TMDELYAKAI SLGVNAAVIH DAGRTQIAAG SATVLGLGPA PKAVLDQITG 120
  121 DLKLY

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 55.920819
Match: PF01981
Description: Peptidyl-tRNA hydrolase PTH2

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
hydrolase activity 1.21132922820114 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.567015167216622 bayes_pls_golite062009
catalytic activity 0.534516847146079 bayes_pls_golite062009
aminoacyl-tRNA hydrolase activity 0.436919034752024 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle