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View Structure Prediction Details

Protein: PTH2
Organism: Saccharomyces cerevisiae
Length: 214 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PTH2.

Description E-value Query
Range
Subject
Range
PTH2 - One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates ...
4.0E-70 [1..214] [1..214]
ENSPTRT00000017368 - null
PTRH2 - peptidyl-tRNA hydrolase 2
gi|190690369, gi... - gi|190691749|gb|ACE87649.1| peptidyl-tRNA hydrolase 2 protein [synthetic construct], gi|190690369|gb...
9.0E-57 [13..214] [3..179]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
4.0E-56 [14..214] [1..176]
gi|9438135 - gi|9438135|gb|AAF87580.1|AF275673_1 unknown [Ochlerotatus triseriatus]
9.0E-49 [24..213] [12..173]
SPAC19A8.14 - aminoacyl-tRNA hydrolase
PTH2_SCHPO - Probable peptidyl-tRNA hydrolase 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC19A...
4.0E-48 [14..214] [6..205]
gi|98960911, gi|... - gi|98960911|gb|ABF58939.1| At5g16870 [Arabidopsis thaliana], gi|18418110|ref|NP_568340.1| aminoacyl-...
2.0E-47 [21..213] [5..168]
gi|8248747, gi|2... - gi|8248747|emb|CAB62849.2| Peptidyl-tRNA hydrolase PTH2, putative [Plasmodium falciparum 3D7], gi|23...
3.0E-46 [27..213] [19..188]

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Predicted Domain #1
Region A:
Residues: [1-89]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITSFLMEKM TVSSNYTIAL WATFTAISFA VGYQLGTSNA SSTKKSSATL LRSKEMKEGK  60
   61 LHNDTDEEES ESEDESDEDE DIESTSLND

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.639 d.58.4 Dimeric alpha+beta barrel
View Download 0.646 d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.395 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.684 d.58.34 Formiminotransferase domain of formiminotransferase-cyclodeaminase.
View Download 0.684 d.58.34 Formiminotransferase domain of formiminotransferase-cyclodeaminase.
View Download 0.646 d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.639 d.58.4 Dimeric alpha+beta barrel
View Download 0.601 d.54.1 Enolase N-terminal domain-like
View Download 0.601 d.54.1 Enolase N-terminal domain-like
View Download 0.395 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.372 a.74.1 Cyclin-like
View Download 0.371 d.58.17 Metal-binding domain
View Download 0.367 a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.358 d.52.7 Ribosome-binding factor A, RbfA
View Download 0.316 a.68.1 Wiscott-Aldrich syndrome protein, WASP, C-terminal domain
View Download 0.278 b.40.2 Bacterial enterotoxins
View Download 0.276 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.254 a.144.1 PABC (PABP) domain
View Download 0.250 b.71.1 Glycosyl hydrolase domain
View Download 0.235 d.67.2 Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
View Download 0.223 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.217 a.39.1 EF-hand
View Download 0.216 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.207 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.200 a.24.13 Domain of the SRP/SRP receptor G-proteins

Predicted Domain #2
Region A:
Residues: [90-214]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPGEVRMALV IRQDLGMTKG KIAAQCCHAA LSCFRHIATN PARASYNPIM TQRWLNAGQA  60
   61 KITLKCPDKF TMDELYAKAI SLGVNAAVIH DAGRTQIAAG SATVLGLGPA PKAVLDQITG 120
  121 DLKLY

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 55.920819
Match: PF01981
Description: Peptidyl-tRNA hydrolase PTH2

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
hydrolase activity 1.21132922820114 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.567015167216622 bayes_pls_golite062009
catalytic activity 0.534516847146079 bayes_pls_golite062009
aminoacyl-tRNA hydrolase activity 0.436919034752024 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle