YRC Public Data Repository - Protein Structure Prediction

Protein:	PTC3
Organism:	Saccharomyces cerevisiae
Length:	468 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PTC3.

Description	E-value	Query Range	Subject Range
gi\|190408880 - gi\|190408880\|gb\|EDV12145.1\| protein phosphatase type 2C [Saccharomyces cerevisiae RM11-1a] gi\|151946340 - gi\|151946340\|gb\|EDN64562.1\| protein phosphatase type 2C [Saccharomyces cerevisiae YJM789] PP2C3_YEAST - Protein phosphatase 2C homolog 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PTC3 PE... PTC3 - Type 2C protein phosphatase; dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activit...	0.0	[1..468]	[1..468]
gi\|38303831, gi\|... - gi\|38303831\|gb\|AAH61986.1\| Ppm1b protein [Rattus norvegicus], gi\|149050512\|gb\|EDM02685.1\| protein ph...	0.0	[1..389]	[1..404]
gi\|55596177 - gi\|55596177\|ref\|XP_525747.1\| PREDICTED: protein phosphatase 1B isoform 5 [Pan troglodytes] PPM1B - protein phosphatase, Mg2+/Mn2+ dependent, 1B gi\|208967196 - gi\|208967196\|dbj\|BAG73612.1\| protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform...	4.0E-99	[1..389]	[1..404]
gi\|17391324, gi\|... - gi\|94403183\|ref\|XP_990021.1\| PREDICTED: similar to Protein phosphatase 2C isoform beta (PP2C-beta) i...	5.0E-99	[1..389]	[1..404]
PPM1A_RABIT - Protein phosphatase 1A OS=Oryctolagus cuniculus GN=PPM1A PE=2 SV=1	4.0E-98	[1..360]	[1..370]
PPM1A_BOVIN - Protein phosphatase 1A OS=Bos taurus GN=PPM1A PE=2 SV=1	7.0E-97	[1..360]	[1..370]

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Predicted Domain #1

Region A:
Residues: [1-303]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQILSNPII DKEHHSGTDC LTAFGLCAMQ GWRMSMEDAH IVEPNLLAES DEEHLAFYGI  60
   61 FDGHGGSSVA EFCGSKMISI LKKQESFKSG MLEQCLIDTF LATDVELLKD EKLKDDHSGC 120
  121 TATVILVSQL KKLLICANSG DSRTVLSTGG NSKAMSFDHK PTLLSEKSRI VAADGFVEMD 180
  181 RVNGNLALSR AIGDFEFKSN TKLGPHEQVV TCVPDIICHN LNYDEDEFVI LACDGIWDCL 240
  241 TSQECVDLVH YGISQGNMTL SDISSRIVDV CCSPTTEGSG IGCDNMSISI VALLKENESE 300
  301 SQW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	499.85005
Match:	1a6q__
Description:	Protein serine/threonine phosphatase 2C, C-terminal domain; Protein serine/threonine phosphatase 2C, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoprotein phosphatase activity	7.29765002420868	bayes_pls_golite062009
phosphatase activity	6.46633224572308	bayes_pls_golite062009
phosphoric ester hydrolase activity	6.25564034681743	bayes_pls_golite062009
protein serine/threonine phosphatase activity	5.66354576593165	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	5.62997267604309	bayes_pls_golite062009
hydrolase activity	2.5631136269171	bayes_pls_golite062009
binding	1.74689317666387	bayes_pls_golite062009
catalytic activity	1.53401212718168	bayes_pls_golite062009
protein binding	0.425331902048676	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [304-377]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FERMRSKNYN IQTSFVQRRK SIFDFHDFSD DDNEVFAITT KKLQDRLNRS KDNDDMEIDD  60
   61 LDTELDSSAT PSKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	499.85005
Match:	1a6q__
Description:	Protein serine/threonine phosphatase 2C, C-terminal domain; Protein serine/threonine phosphatase 2C, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [378-468]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGEDRTGPID LFSLEALLEA GIQIRQRPSS DSDGNTSYFH GASLSDMLAS LSNAAAGETE  60
   61 PNDADDNDDN DGEENGKNEN AKKGSKIEEI E

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: