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View Structure Prediction Details

Protein: AI4
Organism: Saccharomyces cerevisiae
Length: 544 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AI4.

Description E-value Query
Range
Subject
Range
AI4 - Endonuclease I-SceII, encoded by a mobile group I intron within the mitochondrial COX1 gene; intron ...
SCE2_YEAST - Intron-encoded DNA endonuclease aI4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AI4 ...
550.0 [0..1] [544..1]

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Predicted Domain #1
Region A:
Residues: [1-425]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQRWLYSTN AKDIAVLYFM LAIFSGMAGT AMSLIIRLEL AAPGSQYLHG NSQLFNVLVM  60
   61 PALIGGFGNY LLPLMIGATD TAFPRINNIA FWVLPMGLVC LVTSTLVESG AGTGWTVYPP 120
  121 LSSIQAHSGP SVDLAIFALH LTSISSLLGA INFIVTTLNM RTNGMTMHKL PLFVWSIFIT 180
  181 AFLLLLSLPV LSAGITMLLL DRNFNTSFFE VSGGGDPILY EHLFWFFGQT VATIIMLMMY 240
  241 NDMHFSKCWK LLKKWITNIM STLFKALFVK MFMSYNNQQD KMMNNTMLKK DNIKRSSETT 300
  301 RKMLNNSMNK KFNQWLAGLI DGDGYFGIVS KKYVSLEITV ALEDEMALKE IQNKFGGSIK 360
  361 LRSGVKAIRY RLTNKTGMIK LINAVNGNIR NTKRLVQFNK VCILLGIDFI YPIKLTKDNS 420
  421 WFVGF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 135.0
Match: 1occA
Description: Mitochondrial cytochrome c oxidase, subunit I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrogen ion transmembrane transporter activity 2.35288611494101 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 2.17205034949175 bayes_pls_golite062009
heme-copper terminal oxidase activity 2.00288767149295 bayes_pls_golite062009
catalytic activity 1.95966890211023 bayes_pls_golite062009
cytochrome-c oxidase activity 1.60542104698557 bayes_pls_golite062009
oxidoreductase activity, acting on heme group of donors 1.60542104698557 bayes_pls_golite062009
oxidoreductase activity, acting on heme group of donors, oxygen as acceptor 1.60542104698557 bayes_pls_golite062009
binding 0.733970829597091 bayes_pls_golite062009
oxidoreductase activity 0.5109577542055 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.423208299895845 bayes_pls_golite062009
protein binding 0.358081002328109 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [426-544]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDADGTINYS FKNNHPQLTI SVTNKYLQDV QEYKNILGGN IYFDKSQNGY YKWSIQSKDM  60
   61 VLNFINDYIK MNPSRTTKMN KLYLSKEFYN LKELKAYNKS SDSMQYKAWL NFENKWKNK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.221849
Match: 1p8kZ
Description: The structure and DNA recognition of a bifunctional homing endonuclease and group I intron splicing factor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nuclease activity 1.30590086180382 bayes_pls_golite062009
catalytic activity 1.00294942392567 bayes_pls_golite062009
binding 0.947409481120466 bayes_pls_golite062009
nucleic acid binding 0.92351380308588 bayes_pls_golite062009
hydrolase activity 0.908706495902542 bayes_pls_golite062009
endonuclease activity 0.892525491806151 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.861094108940112 bayes_pls_golite062009
DNA binding 0.571084560404215 bayes_pls_golite062009
RNA binding 0.407564756021673 bayes_pls_golite062009

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