YRC Public Data Repository - Protein Structure Prediction

Protein:	TRM44_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	502 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRM44_SCHPO.

Description	E-value	Query Range	Subject Range
TRM44_GIBZE, U38... - Putative methyltransferase UPF0383 OS=Gibberella zeae GN=FG08879 PE=3 SV=1, tRNA (uracil-O(2)-)-meth... TRM44_GIBZE - tRNA (uracil-O(2)-)-methyltransferase OS=Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / ...	694.0	[0..9]	[502..8]
TRM44 - tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(C... TRM44_YEAST - tRNA (uracil-O(2)-)-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TR...	644.0	[0..31]	[502..34]
TRM44_ASHGO - tRNA (uracil-O(2)-)-methyltransferase OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923... TRM44_ASHGO, U38... - Putative methyltransferase UPF0383 OS=Ashbya gossypii GN=AGL241W PE=3 SV=1, tRNA (uracil-O(2)-)-meth...	634.0	[0..32]	[502..17]
gi\|38105732, gi\|... - gi\|39943274\|ref\|XP_361174.1\| hypothetical protein MG03717.4 [Magnaporthe grisea 70-15], gb\|EAA52122....	612.0	[0..51]	[502..1]
TRM44_NEUCR - tRNA (uracil-O(2)-)-methyltransferase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708... TRM44_NEUCR, U38... - Putative methyltransferase UPF0383 OS=Neurospora crassa GN=B13D15.160 PE=3 SV=1, tRNA (uracil-O(2)-)...	608.0	[0..10]	[498..14]
gi\|38567074 - gi\|38567074\|emb\|CAE76371.1\| conserved hypothetical protein [Neurospora crassa]	608.0	[0..10]	[498..65]
gi\|88182478, gi\|... - gi\|88182478\|gb\|EAQ89946.1\| hypothetical protein CHGG_06565 [Chaetomium globosum CBS 148.51], gi\|1161...	577.0	[0..10]	[502..131]
TRM44_KLULA - tRNA (uracil-O(2)-)-methyltransferase OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 707... TRM44_KLULA, U38... - Putative methyltransferase UPF0383 OS=Kluyveromyces lactis GN=KLLA0D12012g PE=3 SV=1, tRNA (uracil-O...	568.0	[0..31]	[502..19]
TRM44_CANGA - tRNA (uracil-O(2)-)-methyltransferase OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / N... TRM44_CANGA, U38... - Putative methyltransferase UPF0383 OS=Candida glabrata GN=CAGL0L12408g PE=3 SV=1, tRNA (uracil-O(2)-...	556.0	[0..31]	[502..24]
gi\|50420993, gi\|... - gi\|50420993\|ref\|XP_459039.1\| hypothetical protein DEHA0D14278g [Debaryomyces hansenii CBS767], gi\|49... U383_DEBHA - Putative methyltransferase UPF0383 - Debaryomyces hansenii (Yeast) (Torulaspora hansenii)	515.0	[0..32]	[502..27]

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Predicted Domain #1

Region A:
Residues: [1-208]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVPAYWKPR EPKNALTCDP PVPYDLQSSY QWQSILEHDT CYAAEVFDKM MIELVYHPER  60
   61 TSSVIMRTDI ILDSQEDDSI LNKQKSVFEN LDERYQISRW IDRRIIPRNT NLDATMDQTV 120
  121 VVLHEKLEND RILMYLPHLD KSLEQPYNHL PYYHPAVAGI AFHYKGSSVE VLYLVEKDFQ 180
  181 RELSSRLLRT AHMLLLVLHK HCKGAVEG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [209-502]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YQKRMLHDTV VERNKFQDTY VILKDKYAKQ LVDNWVEKTD PGKHVFEDLA IAAFLIELWK  60
   61 QTYSSNKEFS FVDVGCGNGL LVYLLLMEGY NGYGFDARKR KSWETYPLWV QVKLYEKVLV 120
  121 PYFLHDFETK IPFPQLPAGF TMSAANIHDG RFSENSFLIG NHADELTPYL PILARLNQKC 180
  181 YFMSIPCCVH DLTGAKISWA LPKPRNPKHG GRYAMYIEWL MQLSEEVGWN IEVEPLRIPS 240
  241 TRNYALIGRK LLSNDLLHSS LSTDALYDIV EKNHGSQGFF VHAMQVAAAN SRSH

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.1
Match:	2bzgA
Description:	Crystal structure of thiopurine S-methyltransferase.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
methyltransferase activity	3.68431317301075	bayes_pls_golite062009
N-methyltransferase activity	3.64494850793256	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	3.60853685152199	bayes_pls_golite062009
protein methyltransferase activity	3.51986359093355	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	2.91374296950366	bayes_pls_golite062009
transferase activity	2.67612625778122	bayes_pls_golite062009
histone methyltransferase activity	2.666651371662	bayes_pls_golite062009
RNA methyltransferase activity	2.63941856307703	bayes_pls_golite062009
tRNA methyltransferase activity	2.21653466290591	bayes_pls_golite062009
rRNA methyltransferase activity	2.14987271695676	bayes_pls_golite062009
arginine N-methyltransferase activity	1.99340565364513	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	1.99340565364513	bayes_pls_golite062009
DNA-methyltransferase activity	1.77527486495102	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	1.64765900536818	bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity	1.54257365884902	bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity	1.54257365884902	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	1.27753381141602	bayes_pls_golite062009
catalytic activity	1.16970557486814	bayes_pls_golite062009
tRNA (adenine)-methyltransferase activity	0.966274102011523	bayes_pls_golite062009
tRNA (adenine-N1-)-methyltransferase activity	0.966274102011523	bayes_pls_golite062009
transcription regulator activity	0.953292160159369	bayes_pls_golite062009
DNA binding	0.878229880745235	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	0.735680462496249	bayes_pls_golite062009
nucleic acid binding	0.668500493633294	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	0.51222176401398	bayes_pls_golite062009
binding	0.486361285495359	bayes_pls_golite062009
RNA binding	0.413112349791396	bayes_pls_golite062009
rRNA (adenine) methyltransferase activity	0.374941249737739	bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity	0.300104233454652	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.286806504860858	bayes_pls_golite062009
protein-arginine omega-N symmetric methyltransferase activity	0.0180486171234466	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: