YRC Public Data Repository - Protein Structure Prediction

Protein:	THI22_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	551 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THI22_SCHPO.

Description	E-value	Query Range	Subject Range
gi\|46116572, gi\|... - gi\|46116572\|ref\|XP_384304.1\| hypothetical protein FG04128.1 [Gibberella zeae PH-1], gi\|42549487\|gb\|E...	414.0	[0..36]	[534..4]
gi\|159129479 - gi\|159129479\|gb\|EDP54593.1\| thiamin biosynthesis protein (Thi-4), putative [Aspergillus fumigatus A1... gi\|71001452, gi\|... - gi\|71001452\|ref\|XP_755407.1\| thiamin biosynthesis protein (Thi-4) [Aspergillus fumigatus Af293], gi\|...	384.0	[0..34]	[536..2]
gi\|115384640, gi... - gi\|115384640\|ref\|XP_001208867.1\| hypothetical protein ATEG_01502 [Aspergillus terreus NIH2624], gi\|1...	375.0	[0..34]	[536..2]
gi\|119178042, gi... - gi\|90299515\|gb\|EAS29146.1\| hypothetical protein CIMG_07892 [Coccidioides immitis RS], gi\|119178042\|r...	371.0	[0..35]	[539..4]
gi\|40738605, gi\|... - gi\|67539524\|ref\|XP_663536.1\| hypothetical protein AN5932.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	367.0	[0..69]	[536..1522]
gi\|32416154, gi\|... - gi\|32416154\|ref\|XP_328555.1\| hypothetical protein [Neurospora crassa], gi\|28924762\|gb\|EAA33874.1\| hy... gi\|85109833 - gi\|85109833\|ref\|XP_963110.1\| hypothetical protein [Neurospora crassa OR74A]	362.0	[0..31]	[534..7]
gi\|50552113, gi\|... - gi\|50552113\|ref\|XP_503531.1\| YALI0E04224p [Yarrowia lipolytica], gi\|49649400\|emb\|CAG79112.1\| unnamed... gi\|49649400 - gi\|49649400\|emb\|CAG79112.1\| YALI0E04224p [Yarrowia lipolytica]	362.0	[0..34]	[538..5]
gi\|4432914, gi\|1... - gi\|4432914\|dbj\|BAA21049.1\| thiamine-4 [Neurospora crassa], pir\|\|T47257 thiamin biosynthesis protein ...	354.0	[0..31]	[506..7]
gi\|38106262, gi\|... - gi\|39939910\|ref\|XP_359492.1\| hypothetical protein MG05285.4 [Magnaporthe grisea 70-15], gb\|EAA52593....	350.0	[0..67]	[526..1]
THI22 - Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with T...	345.0	[0..11]	[539..21]

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Predicted Domain #1

Region A:
Residues: [1-317]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPYNPLYESL SNQFDPSRIE TVLDPMGYTI KRRALPVSLT IAGSDCSGGA GIQADLKTMT  60
   61 SLGVYGMSAI TCLVAENAGG VDSVEEMSPA FVESQIDCCI RDIPCHVVKT GMLGSPEIVK 120
  121 AVARSAKKFN FSKLVVDPVM VATSGDSLVT KDIVSVLNEE LLPLTYLVTP NIPEAIVLAK 180
  181 NQGLDISNIN SVSDMERCAA VIHKLGPKHV LLKGGHMPVN NLGLKSSDDE DLRVVDILYD 240
  241 GNRFYHFSSS YLKKGEVHGT GCTLSSAIAS FLAWEHSLTE AVQFGIDYVH GAITHSPPIN 300
  301 NCSTNILNHM TRLRIVP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	54.221849
Match:	1jxhA
Description:	4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase (HMP-phosphate kinase, ThiD)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphomethylpyrimidine kinase activity	3.972577109569	bayes_pls_golite062009
kinase activity	2.74755351135221	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.43969902311075	bayes_pls_golite062009
carbohydrate kinase activity	2.34445983129813	bayes_pls_golite062009
thiaminase activity	2.33383885490808	bayes_pls_golite062009
transcription regulator activity	2.31951903725366	bayes_pls_golite062009
phosphotransferase activity, phosphate group as acceptor	2.29466565429735	bayes_pls_golite062009
transferase activity	2.15883296431019	bayes_pls_golite062009
nucleic acid binding	2.14277879659132	bayes_pls_golite062009
DNA binding	1.96007866678724	bayes_pls_golite062009
catalytic activity	1.74474587246986	bayes_pls_golite062009
binding	1.4216897826135	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.37866801006693	bayes_pls_golite062009
hydroxyethylthiazole kinase activity	1.28568044601242	bayes_pls_golite062009
thiamin-phosphate diphosphorylase activity	1.27602595951972	bayes_pls_golite062009
transcription factor activity	1.22047633822494	bayes_pls_golite062009
phosphofructokinase activity	0.37205329607884	bayes_pls_golite062009
pyridoxal kinase activity	0.217863391052366	bayes_pls_golite062009
protein binding	0.117280046908929	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [318-551]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FAPGHFIEYI LSHPQVVPAW KEYINHKFTN MLAKGTLPLP AFQDYLKQDY LYLVNFARAY  60
   61 SLKGYKENTF PNILEAAQSV IHVIEEKELH VSMCSSYGVS LQDLKSCEES PACTAYSRYI 120
  121 LDTGAAQDVA ALDFVQAPCL IGYYVIAARL MKEPFRNPQG PYQKWVDNYF CEDYLSAVRR 180
  181 GCRQIEEIVL KLSPERIQEL IEIFIRATKF ETLFWETPYY EYVTKQNLED KEFS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.154902
Match:	1yafA
Description:	Structure of TenA from Bacillus subtilis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	2.47421036599568	bayes_pls_golite062009
binding	1.80342520508546	bayes_pls_golite062009
transcription activator activity	0.765671114434415	bayes_pls_golite062009
catalytic activity	0.476060647762462	bayes_pls_golite062009
protein binding	0.438212622992804	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: