YRC Public Data Repository - Protein Structure Prediction

Protein:	RIB1_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	326 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RIB1_SCHPO.

Description	E-value	Query Range	Subject Range
gi\|53735199, gi\|... - gi\|67922265\|ref\|ZP_00515778.1\| 3,4-Dihydroxy-2-butanone 4-phosphate synthase:GTP cyclohydrolase II [...	426.0	[0..7]	[321..113]
gi\|33861450, gi\|... - gi\|33861450\|ref\|NP_893011.1\| bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohyd...	422.0	[0..7]	[323..126]
gi\|78712790, gi\|... - gi\|78779291\|ref\|YP_397403.1\| bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohyd...	419.0	[0..7]	[326..126]
RIBAB_AQUAE, RIB... - Riboflavin biosynthesis protein ribBA OS=Aquifex aeolicus GN=ribBA PE=3 SV=1, Riboflavin biosynthesi... RIBBA_AQUAE - Riboflavin biosynthesis protein RibBA OS=Aquifex aeolicus (strain VF5) GN=ribBA PE=3 SV=1	416.0	[0..1]	[321..95]
gi\|56420830, gi\|... - gi\|56420830\|ref\|YP_148148.1\| bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohyd...	416.0	[0..8]	[323..103]
gi\|220931844, gi... - gi\|89210620\|ref\|ZP_01189007.1\| 3,4-Dihydroxy-2-butanone 4-phosphate synthase:GTP cyclohydrolase II [...	415.0	[0..1]	[325..96]
gi\|22295453, gi\|... - gi\|22299270\|ref\|NP_682517.1\| bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohyd...	414.0	[0..7]	[321..106]
gi\|28202834, gi\|... - gi\|28210397\|ref\|NP_781341.1\| riboflavin biosynthesis protein ribA [Clostridium tetani E88], gi\|28202...	414.0	[0..1]	[323..96]
gi\|78222835, gi\|... - gi\|78222835\|ref\|YP_384582.1\| GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase [...	414.0	[0..1]	[322..89]
RIBBA_SYNY3 - Riboflavin biosynthesis protein RibBA OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=ribBA PE=3 ... gi\|7428281 - pir\|\|S75629 GTP cyclohydrolase II (EC 3.5.4.25) / 3, 4-dihydroxy-2-butanone 4-phosphate synthase (EC... GCH2_SYNY3, RIBA... - Riboflavin biosynthesis protein ribBA OS=Synechocystis sp. (strain ATCC 27184 / PCC 6803 / N-1) GN=r...	414.0	[0..7]	[321..104]

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Predicted Domain #1

Region A:
Residues: [1-127]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKKEGDQVH HDKTLLQDLS LPENVASEKR LPIDDVQCVN SPMLSPALDI EPKPNVVGTA  60
   61 ERLPKVRCVV RARIPTVKGT EIFLHLYKND FDNKEHLAIV FGQQIRSDSL DAVQEGETEM 120
  121 DRMVRGA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	29.69897
Match:	1iezA
Description:	3,4-dihydroxy-2-butanone 4-phosphate synthase, DHBP synthase, RibB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3,4-dihydroxy-2-butanone-4-phosphate synthase activity	4.65541192907612	bayes_pls_golite062009
GTP cyclohydrolase activity	2.51581618679202	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1.92717548101547	bayes_pls_golite062009
cyclohydrolase activity	1.48770406828775	bayes_pls_golite062009
binding	0.493784774372788	bayes_pls_golite062009
nucleic acid binding	0.464084919475651	bayes_pls_golite062009
catalytic activity	0.343636936190038	bayes_pls_golite062009
DNA binding	0.13720231195318	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [128-326]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YVGTLYPGRK SSYIDVNSSK TTEEQKEEAR KTNFVPLVRI HSECYTGETA WSARCDCGEQ  60
   61 LDEAARLISE EGNGVIIYLR QEGRGIGLSE KLKAYNLQDL GNDTVQANLL LQHPADGRSY 120
  121 AVATAMLMDL GQRDIRLLTN NPEKVNSIEG PNKEVRVVER ISMIPKSWRG EKGIESAEVV 180
  181 LYLKTKIEKM GHLLDLPDS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	70.221849
Match:	2bz0A
Description:	Crystal Structure of E. coli GTP cyclohydrolase II in complex with GTP analogue, GMPcPP, and Zinc
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
GTP cyclohydrolase activity	4.36867535385235	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	3.7708397651039	bayes_pls_golite062009
cyclohydrolase activity	3.33696578638249	bayes_pls_golite062009
catalytic activity	1.40764037338379	bayes_pls_golite062009
binding	0.769835316275102	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: