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View Structure Prediction Details

Protein: VPS41_SCHPO
Organism: Schizosaccharomyces pombe 972h-
Length: 886 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS41_SCHPO.

Description E-value Query
Range
Subject
Range
gi|149032502, gi... - gi|149032502|gb|EDL87380.1| rCG45342, isoform CRA_a [Rattus norvegicus], gi|109505838|ref|XP_0010531...
503.0 [0..24] [828..27]
gi|109066912 - gi|109066912|ref|XP_001101460.1| PREDICTED: vacuolar protein sorting 41 (yeast homolog) [Macaca mula...
502.0 [0..24] [828..53]
gi|74211171 - gi|74211171|dbj|BAE37664.1| unnamed protein product [Mus musculus]
502.0 [0..24] [828..27]
gi|73981907 - gi|73981907|ref|XP_533084.2| PREDICTED: similar to Vacuolar assembly protein VPS41 homolog (S53) [Ca...
501.0 [0..24] [828..28]
VPS41 - vacuolar protein sorting 41 homolog (S. cerevisiae)
500.0 [0..24] [828..28]

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Predicted Domain #1
Region A:
Residues: [1-290]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVDESNSDS EIDSISSSDE DEEPKLIYER ITEKFQGCFM NDTISACAIS KEHFFFGSHN  60
   61 GAIYIYQKNG ILLRKMILHS ASVVDLSVDL ESENLASCSM DGKMIISNIT TRETTVHDFK 120
  121 RPLLSVAIDP YYSTRSSRQV LSGGRAGKVV LSEKGWLGNK DTVLQADCGA VYKISWYTTY 180
  181 IAWASDLGIT VYSTEFGKVL GRLEPPKRLP NDEIFPYQLF WQSESRLVIG WSDQIMIVSI 240
  241 QRSNVANELP KISLQALLEI DSIVSGVLML GFNILTLAYI ANVEDFTSAI 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 63.39794
Match: 1vyhC
Description: PAF-AH Holoenzyme: Lis1/Alfa2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 2.20122168933317 bayes_pls_golite062009
binding 1.99637157021613 bayes_pls_golite062009
actin binding 1.40054662654509 bayes_pls_golite062009
protein binding 1.21879977456466 bayes_pls_golite062009
transporter activity 1.21549336905926 bayes_pls_golite062009
tubulin binding 1.10875870970504 bayes_pls_golite062009
microtubule binding 1.03769395387791 bayes_pls_golite062009
substrate-specific transporter activity 0.734793983890004 bayes_pls_golite062009
nucleic acid binding 0.624115832843391 bayes_pls_golite062009
transcription repressor activity 0.328276176504109 bayes_pls_golite062009
hydrolase activity 0.28424525033024 bayes_pls_golite062009
transcription regulator activity 0.282387003961579 bayes_pls_golite062009
dynein binding 0.180120691665679 bayes_pls_golite062009
structural molecule activity 0.0588151480189092 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.00585398682921312 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [291-357]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSQRIEGCRP ELRLIDSSFK ELCGDAIGLA NYSRLQPSDY HLLPDPSSNS HSFVISPNDI  60
   61 VYVRERN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [358-886]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QIDHVKYLVS KEMYAEAIDA VKKLPEIPPS LQISELAKKY IFHLLGKGQY KEAGMVIPSL  60
   61 YNDNLAEWEQ WVFVFAENDH LEDIADFLPT GENHLSPLVY EMILAQYLAT DERTFNKKLH 120
  121 EWPTMLYSVS TIRNATLKKF KENQKSSTLT ESLAFLYLED NMPIDAFHLY LKLHSELCID 180
  181 LILQHNLYDE ARASVLLLML ISSKGKSSDT KSAMSSMLVQ HVHSFPPQEV IMQIHSVPQF 240
  241 LYEYFCEFEL MYPNSLMEYG DLKLDVFAEF DRKRFFDFLV NTQCYSLDHA AQICKQYNYL 300
  301 DELVYILGRM GNNKEALMLI INELLDIGRA IRYVKEQADR ELWDDLISYS LDKPEFICTL 360
  361 LENIGTDENA RNLLSKIPPG TKLPHMKKSI SKLLADHQSQ VQLYQSCYKL FKNESISMAI 420
  421 KYREQEQSGL EFLVKGKRSK NIFLTNLVKL DNPFNSFGDE QLDYNYRKRI PMIYDLRTKK 480
  481 YIRPEDVRID TDDVFKDDKI AYFKTRMHLK PEVQMRNKLD LLMMLYKQT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 85.69897
Match: 1xi4A
Description: Clathrin D6 Coat
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle