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View Structure Prediction Details

Protein: gi|60654567, gi|...
Organism: synthetic construct
Length: 296 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|60654567, gi|....

Description E-value Query
Range
Subject
Range
gi|109041749 - gi|109041749|ref|XP_001088062.1| PREDICTED: myeloid differentiation primary response gene (88) isofo...
3.0E-76 [1..296] [14..309]
MYD88_MOUSE - Myeloid differentiation primary response protein MyD88 OS=Mus musculus GN=Myd88 PE=1 SV=3
8.0E-76 [1..296] [1..296]
gi|73990168 - gi|73990168|ref|XP_534223.2| PREDICTED: similar to Myeloid differentiation primary response protein ...
6.0E-75 [1..296] [1..296]
gi|32732698, gi|... - gi|37693503|ref|NP_937763.1| myeloid differentiation primary response gene 88 [Rattus norvegicus], g...
6.0E-73 [1..296] [1..296]

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Predicted Domain #1
Region A:
Residues: [1-152]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAGGPGAGS AAPVSSTSSL PLAALNMRVR RRLSLFLNVR TQVAADWTAL AEEMDFEYLE  60
   61 IRQLETQADP TGRLLDAWQG RPGASVGRLL ELLTKLGRDD VLLELGPSIE EDCQKYILKQ 120
  121 QQEEAEKPLQ VAAVDSSVPR TAELAGITTL DD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.154902
Match: 1wmgA
Description: Crystal structure of the UNC5H2 death domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 3.50518632995622 bayes_pls_golite062009
binding 2.81925838257497 bayes_pls_golite062009
transmembrane receptor activity 1.66783807193588 bayes_pls_golite062009
receptor activity 1.49139108045528 bayes_pls_golite062009
enzyme binding 0.78444772609923 bayes_pls_golite062009
tumor necrosis factor binding 0.732234543123958 bayes_pls_golite062009
death receptor activity 0.627802739213643 bayes_pls_golite062009
apoptotic protease activator activity 0.487782160925381 bayes_pls_golite062009
tumor necrosis factor receptor activity 0.428938788578756 bayes_pls_golite062009
Pyrin domain binding 0.307516801321075 bayes_pls_golite062009
identical protein binding 0.206123549797411 bayes_pls_golite062009
signal transducer activity 0.201651915574531 bayes_pls_golite062009
molecular transducer activity 0.201651915574531 bayes_pls_golite062009
protein domain specific binding 0.151782936408674 bayes_pls_golite062009
death domain binding 0.119918387246423 bayes_pls_golite062009
cytokine binding 0.0519010687665362 bayes_pls_golite062009
peptidase activator activity 0.0460645022887266 bayes_pls_golite062009
catalytic activity 0.043183590691418 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [153-296]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLGHMPERFD AFICYCPSDI QFVQEMIRQL EQTNYRLKLC VSDRDVLPGT CVWSIASELI  60
   61 EKRCRRMVVV VSDDYLQSKE CDFQTKFALS LSPGAHQKRL IPIKYKAMKK EFPSILRFIT 120
  121 VCDYTNPCTK SWFWTRLAKA LSLP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.221849
Match: 1fywA
Description: Toll-like receptor 2, TLR2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
double-stranded RNA binding 4.32086914489227 bayes_pls_golite062009
siRNA binding 3.8837709376582 bayes_pls_golite062009
nucleic acid binding 2.46815521682665 bayes_pls_golite062009
binding 2.31499720771829 bayes_pls_golite062009
protein binding 2.10005190551596 bayes_pls_golite062009
receptor activity 1.91178122133017 bayes_pls_golite062009
1.86047705807897 bayes_pls_golite062009
lipopolysaccharide binding 1.79927076993237 bayes_pls_golite062009
transmembrane receptor activity 1.68133457503491 bayes_pls_golite062009
DNA binding 1.10666978727222 bayes_pls_golite062009
RNA binding 0.964496567264848 bayes_pls_golite062009
signal transducer activity 0.574489626172021 bayes_pls_golite062009
molecular transducer activity 0.574489626172021 bayes_pls_golite062009
single-stranded RNA binding 0.0787292540642052 bayes_pls_golite062009
growth factor activity 0.0066769104515047 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle