YRC Public Data Repository - Protein Structure Prediction

Protein:	PFKA_SALPA
Organism:	Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Length:	320 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PFKA_SALPA.

Description	E-value	Query Range	Subject Range
gi\|26111112, gi\|... - gi\|26250681\|ref\|NP_756721.1\| 6-phosphofructokinase [Escherichia coli CFT073], gi\|26111112\|gb\|AAN8329...	0.0	[1..320]	[33..352]
gi\|91075030, gi\|... - gi\|91213456\|ref\|YP_543442.1\| 6-phosphofructokinase [Escherichia coli UTI89], gi\|91075030\|gb\|ABE09911... gi\|226902884, gi... - gi\|237702947\|ref\|ZP_04533428.1\| 6-phosphofructokinase isozyme I [Escherichia sp. 3_2_53FAA], gi\|2269...	0.0	[1..320]	[33..352]
gi\|117626183, gi... - gi\|117626183\|ref\|YP_859506.1\| 6-phosphofructokinase [Escherichia coli APEC O1], gi\|115515307\|gb\|ABJ0... gi\|110807394, gi... - gi\|110807394\|ref\|YP_690914.1\| 6-phosphofructokinase [Shigella flexneri 5 str. 8401], gi\|110616942\|gb...	0.0	[1..320]	[21..340]
K6PF_ERWCT - 6-phosphofructokinase OS=Erwinia carotovora subsp. atroseptica GN=pfkA PE=3 SV=1 PFKA_PECAS - ATP-dependent 6-phosphofructokinase OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)...	0.0	[1..320]	[1..320]
PFKA_ECOL6 - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928... PFKA_ECO27 - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) G... sp\|B7UNN6\|K6PF_ECO27 - 6-phosphofructokinase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=pfkA PE=3 SV=1 K6PF1_ECOL6, K6P... - (Q8FBD0) 6-phosphofructokinase (EC 2.7.1.11) (Phosphofructokinase) (Phosphohexokinase), 6-phosphofru...	0.0	[1..320]	[1..320]
PFKA_ECOBW - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=... gi\|251787179, gi... - gi\|251787179\|ref\|YP_003001483.1\| hypothetical protein B21_03750 [Escherichia coli BL21], gi\|24237945... gi\|253326489, gi... - gi\|254290617\|ref\|YP_003056365.1\| 6-phosphofructokinase [Escherichia coli BL21(DE3)], gi\|253979924\|gb... gi\|253975767, gi... - gi\|254163866\|ref\|YP_003046974.1\| 6-phosphofructokinase [Escherichia coli B str. REL606], gi\|25397576... gi\|254795915, gi... - gi\|254795915\|ref\|YP_003080752.1\| 6-phosphofructokinase I [Escherichia coli O157:H7 str. TW14359], gi... gi\|188492475, gi... - gi\|75513898\|ref\|ZP_00736251.1\| COG0205: 6-phosphofructokinase [Escherichia coli 53638], gi\|188492475... gi\|15834095, gi\|... - gi\|15834095\|ref\|NP_312868.1\| 6-phosphofructokinase [Escherichia coli O157:H7 str. Sakai], gi\|1336431... PFKA_SHISS - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Shigella sonnei (strain Ss046) GN=pfkA PE=3 SV=1 PFKA_ECOL5 - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=... K6P1_ECOLI, K6PF... - 6-phosphofructokinase isozyme 1 (EC 2.7.1.11) (6-phosphofructokinase isozyme I) (Phosphofructokinase... gi\|190907040, gi... - gi\|75240309\|ref\|ZP_00724249.1\| COG0205: 6-phosphofructokinase [Escherichia coli F11], gi\|191172736\|r... gi\|193063953, gi... - gi\|75258101\|ref\|ZP_00729562.1\| COG0205: 6-phosphofructokinase [Escherichia coli E22], gi\|193063953\|r... gi\|85676144, gi\|... - gi\|89110113\|ref\|AP_003893.1\| 6-phosphofructokinase I [Escherichia coli str. K-12 substr. W3110], gi\|... PFKA_SHIDS - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=p... PFKA_SHIBS - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Shigella boydii serotype 4 (strain Sb227) GN=pfkA P... PFKA_SHIB3 - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Shigella boydii serotype 18 (strain CDC 3083-94 / B... PFKA_ECO24 - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli O139:H28 (strain E24377A / ETEC) G... gi\|83569818, gi\|... - gi\|83569818\|ref\|ZP_00921267.1\| COG0205: 6-phosphofructokinase [Shigella dysenteriae 1012], gi\|194433... gi\|194438301, gi... - gi\|83586240\|ref\|ZP_00924876.1\| COG0205: 6-phosphofructokinase [Escherichia coli 101-1], gi\|194438301... gi\|190903552, gi... - gi\|75230437\|ref\|ZP_00716923.1\| COG0205: 6-phosphofructokinase [Escherichia coli B7A], gi\|191166452\|r... gi\|192958673, gi... - gi\|75238359\|ref\|ZP_00722358.1\| COG0205: 6-phosphofructokinase [Escherichia coli E110019], gi\|1930680... PFKA_ECOHS - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli O9:H4 (strain HS) GN=pfkA PE=3 SV=... gi\|194427524, gi... - gi\|75211270\|ref\|ZP_00711369.1\| COG0205: 6-phosphofructokinase [Escherichia coli B171], gi\|194427524\|... PFKA_ECOLC - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Cro... gi\|124527577, gi... - gi\|124527577\|ref\|ZP_01699042.1\| 6-phosphofructokinase [Escherichia coli B], gi\|124501279\|gb\|EAY48744... PFKA_ECOSM - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=pfkA P... PFKA_ECODH - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli (strain K12 / DH10B) GN=pfkA PE=3 ... gi\|208726970, gi... - gi\|208807169\|ref\|ZP_03249506.1\| 6-phosphofructokinase [Escherichia coli O157:H7 str. EC4206], gi\|208... gi\|195937557 - gi\|195937557\|ref\|ZP_03082939.1\| 6-phosphofructokinase [Escherichia coli O157:H7 str. EC4024] gi\|208739822, gi... - gi\|208819699\|ref\|ZP_03260019.1\| 6-phosphofructokinase [Escherichia coli O157:H7 str. EC4042], gi\|208... gi\|208733861, gi... - gi\|208812584\|ref\|ZP_03253913.1\| 6-phosphofructokinase [Escherichia coli O157:H7 str. EC4045], gi\|208... PFKA_ECOSE - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli (strain SE11) GN=pfkA PE=3 SV=1 PFKA_ECO5E - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=... gi\|168755597, gi... - gi\|189357106\|gb\|EDU75525.1\| 6-phosphofructokinase [Escherichia coli O157:H7 str. EC4401], gi\|1687555... gi\|188016803, gi... - gi\|188016803\|gb\|EDU54925.1\| 6-phosphofructokinase [Escherichia coli O157:H7 str. EC4113], gi\|1687487... gi\|189362593, gi... - gi\|189362593\|gb\|EDU81012.1\| 6-phosphofructokinase [Escherichia coli O157:H7 str. EC4486], gi\|1687682... gi\|189367931, gi... - gi\|189367931\|gb\|EDU86347.1\| 6-phosphofructokinase [Escherichia coli O157:H7 str. EC4501], gi\|1687617... gi\|189001500, gi... - gi\|189001500\|gb\|EDU70486.1\| 6-phosphofructokinase [Escherichia coli O157:H7 str. EC4076], gi\|1687808... gi\|187769202, gi... - gi\|187769202\|gb\|EDU33046.1\| 6-phosphofructokinase [Escherichia coli O157:H7 str. EC4196], gi\|1687752... gi\|189378040, gi... - gi\|189378040\|gb\|EDU96456.1\| 6-phosphofructokinase [Escherichia coli O157:H7 str. EC508], gi\|16879950... gi\|189373263, gi... - gi\|189373263\|gb\|EDU91679.1\| 6-phosphofructokinase [Escherichia coli O157:H7 str. EC869], gi\|16878676... EG10699 - 6-phosphofructokinase I / 6-phosphofructokinase-1; allosteric: activated by MgNDPs, inhibited by PEP... PFKA_SHIFL - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Shigella flexneri GN=pfkA PE=3 SV=1 PFKA_ECO57 - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli O157:H7 GN=pfkA PE=3 SV=1 EG10699 - 6-phosphofructokinase I / 6-phosphofructokinase-1; allosteric: activated by MgNDPs, inhibited by PEP... gi\|15804505, gi\|... - gi\|15804505\|ref\|NP_290545.1\| 6-phosphofructokinase [Escherichia coli O157:H7 EDL933], gi\|12518814\|gb... PFKA_ECO8A - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli O8 (strain IAI1) GN=pfkA PE=3 SV=1 gi\|217320854, gi... - gi\|217324633\|ref\|ZP_03440717.1\| 6-phosphofructokinase [Escherichia coli O157:H7 str. TW14588], gi\|21... PFKA_ECO81 - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli O81 (strain ED1a) GN=pfkA PE=3 SV=... PFKA_ECO45 - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=pfk... PFKA_ECO7I - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=pf... PFKA_ECO55 - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli (strain 55989 / EAEC) GN=pfkA PE=3... PFKA_ECOLU - ATP-dependent 6-phosphofructokinase isozyme 1 OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC...	0.0	[1..320]	[1..320]
gi\|229331701, gi... - gi\|229497223\|ref\|ZP_04390924.1\| 6-phosphofructokinase [Geobacillus sp. Y412MC52], gi\|229331701\|gb\|EE... gi\|220707901, gi... - gi\|221088139\|ref\|ZP_03557672.1\| 6-phosphofructokinase [Geobacillus sp. Y412MC61], gi\|220707901\|gb\|EE... PFKA_GEOKA - ATP-dependent 6-phosphofructokinase OS=Geobacillus kaustophilus (strain HTA426) GN=pfkA PE=3 SV=1 K6PF_GEOKA - 6-phosphofructokinase OS=Geobacillus kaustophilus GN=pfkA PE=3 SV=1	0.0	[2..319]	[1..317]
PFKA_ENTCL - ATP-dependent 6-phosphofructokinase OS=Enterobacter cloacae GN=pfkA PE=3 SV=1	0.0	[1..320]	[1..320]
gi\|11259236 - gi\|11259236\|pir\|\|G82045 6-phosphofructokinase, isozyme I VC2689 [imported] - Vibrio cholerae (strain... gi\|197752636, gi... - gi\|254285879\|ref\|ZP_04960841.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae AM-19226], gi\|1977... gi\|153829467, gi... - gi\|153829467\|ref\|ZP_01982134.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae 623-39], gi\|148875... gi\|153825091, gi... - gi\|153825091\|ref\|ZP_01977758.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae MZO-2], gi\|1497412... gi\|227014577, gi... - gi\|227119127\|ref\|YP_002821023.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae O395], gi\|2270145... gi\|9657284, gi\|1... - gi\|9657284\|gb\|AAF95830.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae O1 biovar El Tor str. N1... gi\|227010693, gi... - gi\|227082805\|ref\|YP_002811356.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae M66-2], gi\|227010... gi\|121729840, gi... - gi\|121729840\|ref\|ZP_01682272.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae V52], gi\|121628419... gi\|121546535, gi... - gi\|121591612\|ref\|ZP_01678861.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae 2740-80], gi\|12154... gi\|153221038, gi... - gi\|153221038\|ref\|ZP_01952093.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae MAK 757], gi\|12411... gi\|153212537, gi... - gi\|153212537\|ref\|ZP_01948284.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae 1587], gi\|12411640... gi\|254851225, gi... - gi\|254851225\|ref\|ZP_05240575.1\| 6-phosphofructokinase [Vibrio cholerae MO10], gi\|254846930\|gb\|EET253... gi\|124121047, gi... - gi\|153803414\|ref\|ZP_01958000.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae MZO-3], gi\|1241210... gi\|153820303, gi... - gi\|153820303\|ref\|ZP_01972970.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae NCTC 8457], gi\|126... gi\|194537437, gi... - gi\|254225416\|ref\|ZP_04919027.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae V51], gi\|194537437... gi\|126518420, gi... - gi\|153824056\|ref\|ZP_01976723.1\| 6-phosphofructokinase, isozyme I [Vibrio cholerae B33], gi\|126518420...	0.0	[1..320]	[12..331]
PFKA_VIBCH - ATP-dependent 6-phosphofructokinase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba... gi\|116221049, gi... - gi\|75819872\|ref\|ZP_00749935.1\| COG0205: 6-phosphofructokinase [Vibrio cholerae V51], gi\|116221049\|re... gi\|75814340 - gi\|75814340\|ref\|ZP_00744943.1\| COG0205: 6-phosphofructokinase [Vibrio cholerae V52] K6PF_VIBCH - 6-phosphofructokinase OS=Vibrio cholerae GN=pfkA PE=3 SV=2 gi\|75830102, gi\|... - gi\|75830102\|ref\|ZP_00759387.1\| COG0205: 6-phosphofructokinase [Vibrio cholerae MO10], gi\|116190677\|r... gi\|75827932 - gi\|75827932\|ref\|ZP_00757367.1\| COG0205: 6-phosphofructokinase [Vibrio cholerae O395]	0.0	[1..320]	[1..320]

Back

Predicted Domain #1

Region A:
Residues: [1-320]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKKIGVLTS GGDAPGMNAA IRGVVRAALT EGLEVMGIYD GYLGLYEDRM VQLDRYSVSD  60
   61 MINRGGTFLG SARFPEFRDE NIRAVAIENL KKRGIDALVV IGGDGSYMGA KRLTEMGFPC 120
  121 IGLPGTIDND IKGTDYTIGY FTALGTVVEA IDRLRDTSSS HQRISIVEVM GRYCGDLTLA 180
  181 AAIAGGCEFI VVPEVEFNRE DLVAEIKAGI AKGKKHAIVA ITEHMCDVDE LAHFIEKETG 240
  241 RETRATVLGH IQRGGSPVPY DRILASRMGA YAIDLLLEGH GGRCVGIQNE QLVHHDIIDA 300
  301 IENMKRPFKS DWMECAKKLY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	122.0
Match:	1pfkA
Description:	ATP-dependent phosphofructokinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
6-phosphofructokinase activity	12.7403693686468	bayes_pls_golite062009
phosphofructokinase activity	11.7059647240147	bayes_pls_golite062009
carbohydrate kinase activity	9.54757838113048	bayes_pls_golite062009
fructose-6-phosphate binding	7.12870468168491	bayes_pls_golite062009
fructose binding	7.0070117394116	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	2.40595318732289	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.20407391743017	bayes_pls_golite062009
kinase activity	2.09076306615481	bayes_pls_golite062009
transferase activity	1.97789134877808	bayes_pls_golite062009
catalytic activity	1.89212073381079	bayes_pls_golite062009
monosaccharide binding	0.93954836516667	bayes_pls_golite062009
binding	0.692710585652872	bayes_pls_golite062009
hydrolase activity	0.276140444059183	bayes_pls_golite062009
fructose-2,6-bisphosphate 2-phosphatase activity	0.13423626204854	bayes_pls_golite062009
sugar binding	0.0026978348896064	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: