YRC Public Data Repository - Protein Structure Prediction

Protein:	GAL1_YERPG
Organism:	Yersinia pestis Angola
Length:	383 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GAL1_YERPG.

Description	E-value	Query Range	Subject Range
gi\|77973946, gi\|... - gi\|77973946\|ref\|ZP_00829490.1\| COG0153: Galactokinase [Yersinia frederiksenii ATCC 33641], gi\|238788...	8.0E-96	[1..383]	[1..383]
GAL1_YERPB - Galactokinase OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=galK PE=3 SV=1 GAL1_YERPS - Galactokinase OS=Yersinia pseudotuberculosis GN=galK PE=3 SV=1 GAL1_YERPS - Galactokinase OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=galK PE=3 SV=1	1.0E-94	[1..383]	[1..383]
gi\|238798986, gi... - gi\|77960611\|ref\|ZP_00824475.1\| COG0153: Galactokinase [Yersinia mollaretii ATCC 43969], gi\|238798986...	1.0E-94	[1..383]	[1..383]
gi\|238785688, gi... - gi\|77956870\|ref\|ZP_00820945.1\| COG0153: Galactokinase [Yersinia bercovieri ATCC 43970], gi\|238785688...	6.0E-94	[1..383]	[1..383]
gi\|77976564, gi\|... - gi\|77976564\|ref\|ZP_00832046.1\| COG0153: Galactokinase [Yersinia intermedia ATCC 29909], gi\|238793910...	9.0E-94	[1..383]	[1..383]
GAL1_SALDC - Galactokinase OS=Salmonella dublin (strain CT_02021853) GN=galK PE=3 SV=1 gi\|200391087, gi... - gi\|200391087\|ref\|ZP_03217698.1\| galactokinase [Salmonella enterica subsp. enterica serovar Virchow s... gi\|204930110, gi... - gi\|204930110\|ref\|ZP_03221131.1\| galactokinase [Salmonella enterica subsp. enterica serovar Javiana s... gi\|29142528, gi\|... - gi\|29142528\|ref\|NP_805870.1\| galactokinase [Salmonella enterica subsp. enterica serovar Typhi str. T... gi\|16759699 - gi\|16759699\|ref\|NP_455316.1\| galactokinase [Salmonella enterica subsp. enterica serovar Typhi str. C... GAL1_SALTI - Galactokinase OS=Salmonella typhi GN=galK PE=3 SV=1 GAL1_SALTI - Galactokinase OS=Salmonella typhi GN=galK PE=3 SV=1 gi\|238913334 - gi\|238913334\|ref\|ZP_04657171.1\| galactokinase [Salmonella enterica subsp. enterica serovar Tennessee... gi\|214001892 - gi\|214001892\|ref\|ZP_03412627.1\| galactokinase [Salmonella enterica subsp. enterica serovar Typhi str... GAL1_SALEP - Galactokinase OS=Salmonella enteritidis PT4 (strain P125109) GN=galK PE=3 SV=1 gi\|213023145 - gi\|213023145\|ref\|ZP_03337592.1\| galactokinase [Salmonella enterica subsp. enterica serovar Typhi str... gi\|213427697 - gi\|213427697\|ref\|ZP_03360447.1\| galactokinase [Salmonella enterica subsp. enterica serovar Typhi str... gi\|213613330 - gi\|213613330\|ref\|ZP_03371156.1\| galactokinase [Salmonella enterica subsp. enterica serovar Typhi str...	6.0E-93	[1..383]	[1..382]
gi\|205327714, gi... - gi\|205327714\|gb\|EDZ14478.1\| galactokinase [Salmonella enterica subsp. enterica serovar 4,[5],12:i:- ... GAL1_SALTY - Galactokinase OS=Salmonella typhimurium GN=galK PE=3 SV=2 GAL1_SALNS - Galactokinase OS=Salmonella newport (strain SL254) GN=galK PE=3 SV=1 lcl\|NC_016856.1_... - [gene=galK] [protein=galactokinase] [protein_id=YP_005236493.1] [location=complement(838713..839861)... GAL1_SALTY - Galactokinase OS=Salmonella typhimurium GN=galK PE=3 SV=2 GAL1_SALTY - Galactokinase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=galK PE=3 SV=2	1.0E-92	[1..383]	[1..382]
GAL1_SALCH - Galactokinase OS=Salmonella choleraesuis GN=galK PE=3 SV=1 GAL1_SALCH - Galactokinase OS=Salmonella choleraesuis GN=galK PE=3 SV=1 GAL1_SALCH - Galactokinase OS=Salmonella choleraesuis (strain SC-B67) GN=galK PE=3 SV=1	4.0E-92	[1..383]	[1..382]
gi\|86516618 - gi\|86516618\|gb\|ABC98001.1\| GalK [Shigella boydii]	6.0E-92	[1..383]	[1..382]
GAL1_SALPA - Galactokinase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=galK PE=3 SV=1 GAL1_SALPA - Galactokinase OS=Salmonella paratyphi A GN=galK PE=3 SV=1 GAL1_SALPK - Galactokinase OS=Salmonella paratyphi A (strain AKU_12601) GN=galK PE=3 SV=1	7.0E-92	[1..383]	[1..382]

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Predicted Domain #1

Region A:
Residues: [1-383]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLKQHTQTI FRQQFDRESD ITIKAPGRVN LIGEHTDYND GFVLPCAINY ETVISCGKRD  60
   61 DRQIRVIAAD YENQQDIFSL DAPIVPHPEY RWADYVRGVV KHLQMRNADF GGADLVICGN 120
  121 VPQGAGLSSS ASLEVAVGQA LQSLYQLPLS GVELALNGQE AENQFVGCNC GIMDQLISAL 180
  181 GKKDHALLID CRTLETRAVP MPENMAVVII NSNIQRGLVD SEYNTRRQQC EAAARFFGVK 240
  241 ALRDVEPSLF FSIQDELDPV VAKRARHVIS ENARTLAAAD ALAAGNLKLM GQLMQESHIS 300
  301 MRDDFEITVP PIDRLVEIVK SVIGDQGGVR MTGGGFGGCI IALMPLELVE QVRTTVAQEY 360
  361 PAHSGGKKET FYVCQASQGA GLC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	83.0
Match:	1wuuA
Description:	crystal structure of human galactokinase complexed with MgAMPPNP and galactose
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	2.57444343595083	bayes_pls_golite062009
kinase activity	2.45533953107206	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.15678581504347	bayes_pls_golite062009
galactokinase activity	1.98579505313408	bayes_pls_golite062009
transferase activity	1.44847475955289	bayes_pls_golite062009
galactose binding	1.09822999475915	bayes_pls_golite062009
ribonuclease activity	0.861708516886368	bayes_pls_golite062009
catalytic activity	0.836142537655721	bayes_pls_golite062009
binding	0.81933081762145	bayes_pls_golite062009
nuclease activity	0.750627453499812	bayes_pls_golite062009
hydrolase activity	0.740929677099368	bayes_pls_golite062009
3'-5'-exoribonuclease activity	0.29372632468704	bayes_pls_golite062009
exoribonuclease activity	0.268974873769861	bayes_pls_golite062009
protein binding	0.252740644591197	bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters	0.24527927280502	bayes_pls_golite062009
carbohydrate kinase activity	0.236567582613739	bayes_pls_golite062009
structural constituent of ribosome	0.168901349358066	bayes_pls_golite062009
peptidase activity	0.14842914604274	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: