YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|89110413, gi\|...
Organism:	Escherichia coli str. K-12 substr. W3110
Length:	637 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|89110413, gi|....

Description	E-value	Query Range	Subject Range
gi\|62182179, gi\|... - gi\|62182179\|ref\|YP_218596.1\| PTS family, mannitol-specific enzyme IIABC components [Salmonella enter...	419.0	[0..1]	[637..1]
gi\|75228662, gi\|... - gi\|75228662\|ref\|ZP_00715283.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ... gi\|75188362, gi\|... - gi\|75188362\|ref\|ZP_00701629.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ... gi\|75179770, gi\|... - gi\|75179770\|ref\|ZP_00699757.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ... gi\|170018170, gi... - gi\|170018170\|ref\|YP_001723124.1\| PTS system, mannitol-specific IIC subunit [Escherichia coli ATCC 87... gi\|73857644, gi\|... - gi\|74314167\|ref\|YP_312586.1\| PTS system, mannitol-specific enzyme IIABC components [Shigella sonnei ... gi\|75255815, gi\|... - gi\|75255815\|ref\|ZP_00727561.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ... gi\|124499171, gi... - gi\|124530530\|ref\|ZP_01701157.1\| PTS system, mannitol-specific IIC subunit [Escherichia coli B], gi\|1...	416.0	[0..1]	[637..1]
gi\|30065127, gi\|... - gi\|30065127\|ref\|NP_839298.1\| PTS system, mannitol-specific enzyme IIABC components [Shigella flexner... gi\|24114863, gi\|... - gi\|24114863\|ref\|NP_709373.1\| PTS system, mannitol-specific enzyme IIABC components [Shigella flexner... gi\|110617279, gi... - gi\|110807731\|ref\|YP_691251.1\| PTS system, mannitol-specific enzyme IIABC components [Shigella flexne...	416.0	[0..1]	[637..1]
gi\|194414527, gi... - gi\|75211354\|ref\|ZP_00711453.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ...	416.0	[0..1]	[637..1]
gi\|117625875, gi... - gi\|117625875\|ref\|YP_859198.1\| fused mannitol-specific PTS enzymes: IIA components/IIB components/IIC... gi\|237703365, gi... - gi\|237703365\|ref\|ZP_04533846.1\| mannitol-specific PTS system enzyme IIABC component [Escherichia sp.... gi\|91074684, gi\|... - gi\|91213110\|ref\|YP_543096.1\| mannitol-specific PTS system enzyme IIABC components [Escherichia coli ... gi\|218560670, gi... - gi\|218560670\|ref\|YP_002393583.1\| fused mannitol-specific PTS enzymes: IIA components ; IIB component...	415.0	[0..1]	[637..1]
gi\|168779748, gi... - gi\|189002293\|gb\|EDU71279.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|209747460, gi... - pir\|\|C91188 hypothetical protein ECs4475 [imported] - Escherichia coli (strain O157:H7, substrain R... gi\|189380162, gi... - gi\|189380162\|gb\|EDU98578.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|195935125 - gi\|195935125\|ref\|ZP_03080507.1\| mannitol-specific PTS system enzyme IIABC components [Escherichia co... gi\|208725580, gi... - gi\|208805779\|ref\|ZP_03248116.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157... gi\|168753416, gi... - gi\|189358801\|gb\|EDU77220.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|168759690, gi... - gi\|189369645\|gb\|EDU88061.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|15833729, gi\|... - gi\|15833729\|ref\|NP_312502.1\| mannitol-specific PTS system enzyme IIABC components [Escherichia coli ... gi\|189364590, gi... - gi\|189364590\|gb\|EDU83009.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|187771479, gi... - gi\|187771479\|gb\|EDU35323.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|254795553, gi... - gi\|254795553\|ref\|YP_003080390.1\| fused mannitol-specific PTS enzymes: IIA components, IIB components... gi\|188018385, gi... - gi\|188018385\|gb\|EDU56507.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|15833729, gi\|... - gi\|15833729\|ref\|NP_312502.1\| mannitol-specific PTS system enzyme IIABC components [Escherichia coli ... gi\|208812259, gi... - gi\|208812259\|ref\|ZP_03253588.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157... gi\|208740178, gi... - gi\|208820055\|ref\|ZP_03260375.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157... gi\|209158199, gi... - gi\|209396799\|ref\|YP_002273078.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O15... gi\|217326167, gi... - gi\|217326167\|ref\|ZP_03442251.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157...	415.0	[0..1]	[637..1]
gi\|227839344, gi... - gi\|227883764\|ref\|ZP_04001569.1\| protein-N(pi)-phosphohistidine--sugar phosphotransferase [Escherichi... gi\|110345432, gi... - gi\|110643840\|ref\|YP_671570.1\| PTS system, mannitol-specific IIABC component [Escherichia coli 536], ... gi\|215266950, gi... - gi\|215488878\|ref\|YP_002331309.1\| fused mannitol-specific PTS enzymes: IIA components /IIB components... gi\|218691882, gi... - gi\|218691882\|ref\|YP_002400094.1\| fused mannitol-specific PTS enzymes: IIA components ; IIB component... gi\|26250238, gi\|... - gi\|26250238\|ref\|NP_756278.1\| PTS system, mannitol-specific IIABC component [Escherichia coli CFT073]... gi\|191170342, gi... - gi\|75242618\|ref\|ZP_00726362.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ...	415.0	[0..1]	[637..1]
gi\|82545959, gi\|... - gi\|82545959\|ref\|YP_409906.1\| PTS system mannitol-specific enzyme IIABC components [Shigella boydii S...	414.0	[0..1]	[637..1]
gi\|25287847 - pir\|\|C86035 hypothetical protein mtlA [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|15804140, gi\|... - gi\|15804140\|ref\|NP_290179.1\| PTS system, mannitol-specific enzyme IIABC components [Escherichia coli...	414.0	[0..1]	[637..1]
gi\|197938947, gi... - gi\|198244431\|ref\|YP_002217646.1\| pts system mannitol-specific eiicba component [Salmonella enterica ... gi\|16504929, gi\|... - gi\|25287848\|pir\|\|AI0976 mannitol-specific enzyme II of phosphotransferase system [imported] - Salmon... gi\|197364504, gi... - gi\|197364504\|ref\|YP_002144141.1\| mannitol-specific enzyme II of phosphotransferase system [Salmonell... gi\|213650628 - gi\|213650628\|ref\|ZP_03380681.1\| pts system mannitol-specific eiicba component [Salmonella enterica s... gi\|213610022 - gi\|213610022\|ref\|ZP_03369848.1\| pts system mannitol-specific eiicba component [Salmonella enterica s... gi\|16762624 - gi\|16762624\|ref\|NP_458241.1\| mannitol-specific enzyme II of phosphotransferase system [Salmonella en... gi\|194449488, gi... - gi\|194449488\|ref\|YP_002047714.1\| pts system mannitol-specific eiicba component [Salmonella enterica ... gi\|194400974, gi... - gi\|194442311\|ref\|YP_002042933.1\| pts system mannitol-specific eiicba component [Salmonella enterica ... gi\|16766970, gi\|... - gi\|16766970\|ref\|NP_462585.1\| mannitol-specific enzyme IIABC component [Salmonella typhimurium LT2], ... gi\|197211207, gi... - gi\|197247504\|ref\|YP_002148616.1\| pts system mannitol-specific eiicba component [Salmonella enterica ... gi\|29139750, gi\|... - gi\|29144113\|ref\|NP_807455.1\| mannitol-specific enzyme II of phosphotransferase system [Salmonella en... gi\|194456379, gi... - gi\|194470015\|ref\|ZP_03075999.1\| pts system mannitol-specific eiicba component [Salmonella enterica s... gi\|56415577, gi\|... - gi\|56415577\|ref\|YP_152652.1\| mannitol-specific enzyme II of phosphotransferase system [Salmonella en... gi\|205338747, gi... - gi\|205338747\|gb\|EDZ25511.1\| pts system mannitol-specific eiicba component [Salmonella enterica subsp... lcl\|NC_016856.1_... - [gene=mtlA] [protein=mannitol-specific enzyme IIABC component] [protein_id=YP_005239923.1] [location... gi\|168232528, gi... - gi\|205333241\|gb\|EDZ20005.1\| pts system mannitol-specific eiicba component [Salmonella enterica subsp... gi\|168818485, gi... - gi\|205344403\|gb\|EDZ31167.1\| pts system mannitol-specific eiicba component [Salmonella enterica subsp... gi\|205350428, gi... - gi\|205350428\|gb\|EDZ37059.1\| pts system mannitol-specific eiicba component [Salmonella enterica subsp... gi\|161616759, gi... - gi\|161616759\|ref\|YP_001590724.1\| hypothetical protein SPAB_04578 [Salmonella enterica subsp. enteric... gi\|205330644, gi... - gi\|205330644\|gb\|EDZ17408.1\| pts system mannitol-specific eiicba component [Salmonella enterica subsp... gi\|205325653, gi... - gi\|205325653\|gb\|EDZ13492.1\| pts system mannitol-specific eiicba component [Salmonella enterica subsp... gi\|224470012, gi... - gi\|224585484\|ref\|YP_002639283.1\| mannitol-specific enzyme II of phosphotransferase system [Salmonell... gi\|214001133 - gi\|214001133\|ref\|ZP_03411868.1\| pts system mannitol-specific eiicba component [Salmonella enterica s...	406.0	[0..1]	[637..1]

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Predicted Domain #1

Region A:
Residues: [1-146]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSDIKIKVQ SFGRFLSNMV MPNIGAFIAW GIITALFIPT GWLPNETLAK LVGPMITYLL  60
   61 PLLIGYTGGK LVGGERGGVV GAITTMGVIV GADMPMFLGS MIAGPLGGWC IKHFDRWVDG 120
  121 KIKSGFEMLV NNFSAGIIGM ILAILA

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [147-339]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FLGIGPIVEA LSKMLAAGVN FMVVHDMLPL ASIFVEPAKI LFLNNAINHG IFSPLGIQQS  60
   61 HELGKSIFFL IEANPGPGMG VLLAYMFFGR GSAKQSAGGA AIIHFLGGIH EIYFPYVLMN 120
  121 PRLILAVILG GMTGVFTLTI LGGGLVSPAS PGSILAVLAM TPKGAYFANI AGVCAAMAVS 180
  181 FVVSAILLKT SKV

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [340-504]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEEDDIEAAT RRMQDMKAES KGASPLSAGD VTNDLSHVRK IIVACDAGMG SSAMGAGVLR  60
   61 KKIQDAGLSQ ISVTNSAINN LPPDVDLVIT HRDLTERAMR QVPQAQHISL TNFLDSGLYT 120
  121 SLTERLVAAQ RHTANEEKVK DSLKDSFDDS SANLFKLGAE NIFLG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.39794
Match:	1vkrA
Description:	STRUCTURE OF IIB DOMAIN OF THE MANNITOL-SPECIFIC PERMEASE ENZYME II
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	5.08041453921791	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	4.49138214292642	bayes_pls_golite062009
fructose transmembrane transporter activity	2.02791322402201	bayes_pls_golite062009
sugar transmembrane transporter activity	1.77053981674308	bayes_pls_golite062009
transporter activity	1.6837050020547	bayes_pls_golite062009
transmembrane transporter activity	1.5685227361887	bayes_pls_golite062009
monosaccharide transmembrane transporter activity	1.38987536600292	bayes_pls_golite062009
substrate-specific transporter activity	1.32293422112884	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.217268678967	bayes_pls_golite062009
active transmembrane transporter activity	1.12964417923438	bayes_pls_golite062009
hexose transmembrane transporter activity	0.80355002679172	bayes_pls_golite062009
binding	0.472595683811139	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.37663629577414	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.0296784994545702	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [505-637]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKAATKEEAI RFAGEQLVKG GYVEPEYVQA MLDREKLTPT YLGESIAVPH GTVEAKDRVL  60
   61 KTGVVFCQYP EGVRFGEEED DIARLVIGIA ARNNEHIQVI TSLTNALDDE SVIERLAHTT 120
  121 SVDEVLELLA GRK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	31.0
Match:	1a3aA
Description:	Phosphotransferase IIa-mannitol
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	4.89047341597444	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	3.92377913213665	bayes_pls_golite062009
transporter activity	2.16741930408232	bayes_pls_golite062009
transmembrane transporter activity	2.05879816720019	bayes_pls_golite062009
active transmembrane transporter activity	1.87457143976439	bayes_pls_golite062009
substrate-specific transporter activity	1.82451780056478	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.7251575499811	bayes_pls_golite062009
binding	0.396676636991646	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.19707628828681	bayes_pls_golite062009
ion transmembrane transporter activity	0.12881601139602	bayes_pls_golite062009
anion transmembrane transporter activity	0.10209580008722	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: