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View Structure Prediction Details

Protein: gi|240849537, gi...
Organism: Homo sapiens
Length: 839 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|240849537, gi....

Description E-value Query
Range
Subject
Range
gi|109067817 - gi|109067817|ref|XP_001091632.1| PREDICTED: similar to component of oligomeric golgi complex 5 isofo...
0.0 [1..839] [1..839]
COG5 - component of oligomeric golgi complex 5
0.0 [1..839] [1..839]
gi|114615378 - gi|114615378|ref|XP_001163243.1| PREDICTED: component of oligomeric golgi complex 5 isoform 3 [Pan t...
0.0 [1..839] [1..839]
gi|26326643 - gi|26326643|dbj|BAC27065.1| unnamed protein product [Mus musculus]
0.0 [25..839] [1..836]

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Predicted Domain #1
Region A:
Residues: [1-115]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGWVGGRRRD SASPPGRSRS AADDINPAPA NMEGGGGSVA VAGLGARGSG AAAATVRELL  60
   61 QDGCYSDFLN EDFDVKTYTS QSIHQAVIAE QLAKLAQGIS QLDRELHLQV VARHE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.0
Match: 1dg3A
Description: Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain; Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [116-467]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLLAQATGIE SLEGVLQMMQ TRIGALQGAV DRIKAKIVEP YNKIVARTAQ LARLQVACDL  60
   61 LRRIIRILNL SKRLQGQLQG GSREITKAAQ SLNELDYLSQ GIDLSGIEVI ENDLLFIARA 120
  121 RLEVENQAKR LLEQGLETQN PTQVGTALQV FYNLGTLKDT ITSVVDGYCA TLEENINSAL 180
  181 DIKVLTQPSQ SAVRGGPGRS TMPTPGNTAA LRASFWTNME KLMDHIYAVC GQVQHLQKVL 240
  241 AKKRDPVSHI CFIEEIVKDG QPEIFYTFWN SVTQALSSQF HMATNSSMFL KQAFEGEYPK 300
  301 LLRLYNDLWK RLQQYSQHIQ GNFNASGTTD LYVDLQHMED DAQDIFIPKK PD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.0
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [468-634]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDPEKALKDS LQPYEAAYLS KSLSRLFDPI NLVFPPGGRN PPSSDELDGI IKTIASELNV  60
   61 AAVDTNLTLA VSKNVAKTIQ LYSVKSEQLL STQGDASQVI GPLTEGQRRN VAVVNSLYKL 120
  121 HQSVTKAIHA LMENAVQPLL TSVGDAIEAI IITMHQEDFS GSLSSSG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [635-751]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPDVPCSLYM KELQGFIARV MSDYFKHFEC LDFVFDNTEA IAQRAVELFI RHASLIRPLG  60
   61 EGGKMRLAAD FAQMELAVGP FCRRVSDLGK SYRMLRSFRP LLFQASEHVA SSPALGD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [752-839]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VIPFSIIIQF LFTRAPAELK SPFQRAEWSH TRFSQWLDDH PSEKDRLLLI RGALEAYVQS  60
   61 VRSREGKEFA PVYPIMVQLL QKAMSALQ

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.975
Match: 1sv0A
Description: Crystal Structure Of Yan-SAM/Mae-SAM Complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.76553673800266 bayes_pls_golite062009
protein binding 1.96434025125047 bayes_pls_golite062009
transcription regulator activity 1.82619147445372 bayes_pls_golite062009
DNA binding 1.40903533329696 bayes_pls_golite062009
nucleic acid binding 1.38211918800351 bayes_pls_golite062009
transcription factor activity 1.05134679312138 bayes_pls_golite062009
sphingomyelin synthase activity 0.826637723127231 bayes_pls_golite062009
ceramide cholinephosphotransferase activity 0.826637723127231 bayes_pls_golite062009
transcription repressor activity 0.715530371553761 bayes_pls_golite062009
catalytic activity 0.0823489300960689 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle