YRC Public Data Repository - Protein Structure Prediction

Protein:	DHNA_ECOLI
Organism:	Escherichia coli
Length:	434 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DHNA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|75255624 - gi\|75255624\|ref\|ZP_00727403.1\| COG1252: NADH dehydrogenase, FAD-containing subunit [Escherichia coli... gi\|75208964 - gi\|75208964\|ref\|ZP_00709234.1\| COG1252: NADH dehydrogenase, FAD-containing subunit [Escherichia coli...	338.0	[0..10]	[434..2]
gi\|75195292 - gi\|75195292\|ref\|ZP_00705362.1\| COG1252: NADH dehydrogenase, FAD-containing subunit [Escherichia coli... gi\|75190166 - gi\|75190166\|ref\|ZP_00703433.1\| COG1252: NADH dehydrogenase, FAD-containing subunit [Escherichia coli... gi\|75511402 - gi\|75511402\|ref\|ZP_00734085.1\| COG1252: NADH dehydrogenase, FAD-containing subunit [Escherichia coli... gi\|75234217 - gi\|75234217\|ref\|ZP_00718610.1\| COG1252: NADH dehydrogenase, FAD-containing subunit [Escherichia coli... gi\|75228220 - gi\|75228220\|ref\|ZP_00714879.1\| COG1252: NADH dehydrogenase, FAD-containing subunit [Escherichia coli...	337.0	[0..10]	[434..2]
gi\|83584876 - gi\|83584876\|ref\|ZP_00923534.1\| COG1252: NADH dehydrogenase, FAD-containing subunit [Escherichia coli...	337.0	[0..10]	[434..2]
gi\|75239606 - gi\|75239606\|ref\|ZP_00723573.1\| COG1252: NADH dehydrogenase, FAD-containing subunit [Escherichia coli... gi\|83569568 - gi\|83569568\|ref\|ZP_00921020.1\| COG1252: NADH dehydrogenase, FAD-containing subunit [Shigella dysente... gi\|115512418, gi... - gi\|117623294\|ref\|YP_852207.1\| NADH dehydrogenase [Escherichia coli APEC O1], gi\|115512418\|gb\|ABJ0049...	337.0	[0..10]	[434..2]
gi\|110614671, gi... - gi\|110805123\|ref\|YP_688643.1\| respiratory NADH dehydrogenase [Shigella flexneri 5 str. 8401], gi\|110...	337.0	[0..10]	[434..2]
gi\|75175768 - gi\|75175768\|ref\|ZP_00695968.1\| COG1252: NADH dehydrogenase, FAD-containing subunit [Shigella boydii ...	335.0	[0..10]	[434..2]
gi\|73855147, gi\|... - gi\|74311670\|ref\|YP_310089.1\| respiratory NADH dehydrogenase [Shigella sonnei Ss046], gi\|73855147\|gb\|...	334.0	[0..1]	[434..1]
gi\|218557990, gi... - gi\|218557990\|ref\|YP_002390903.1\| respiratory NADH dehydrogenase 2/cupric reductase [Escherichia coli... gi\|218689061, gi... - gi\|218689061\|ref\|YP_002397273.1\| respiratory NADH dehydrogenase 2/cupric reductase [Escherichia coli... gi\|110641285, gi... - gi\|110641285\|ref\|YP_669015.1\| NADH dehydrogenase [Escherichia coli 536], gi\|110342877\|gb\|ABG69114.1\|... gi\|191173126, gi... - gi\|191173126\|ref\|ZP_03034659.1\| NADH dehydrogenase [Escherichia coli F11], gi\|190906671\|gb\|EDV66277.... gi\|194433648, gi... - gi\|194433648\|ref\|ZP_03065924.1\| NADH dehydrogenase [Shigella dysenteriae 1012], gi\|194418077\|gb\|EDX3...	334.0	[0..1]	[434..1]
gi\|30062642, gi\|... - gi\|30062642\|ref\|NP_836813.1\| respiratory NADH dehydrogenase [Shigella flexneri 2a str. 2457T], gi\|30... gi\|56383375, gi\|... - gi\|56479824\|ref\|NP_707024.2\| respiratory NADH dehydrogenase [Shigella flexneri 2a str. 301], gi\|5638...	334.0	[0..1]	[434..1]
gi\|82777278, gi\|... - gi\|82777278\|ref\|YP_403627.1\| respiratory NADH dehydrogenase [Shigella dysenteriae Sd197], gi\|8124142...	332.0	[0..1]	[434..1]

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Predicted Domain #1

Region A:
Residues: [1-434]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTPLKKIVI VGGGAGGLEM ATQLGHKLGR KKKAKITLVD RNHSHLWKPL LHEVATGSLD  60
   61 EGVDALSYLA HARNHGFQFQ LGSVIDIDRE AKTITIAELR DEKGELLVPE RKIAYDTLVM 120
  121 ALGSTSNDFN TPGVKENCIF LDNPHQARRF HQEMLNLFLK YSANLGANGK VNIAIVGGGA 180
  181 TGVELSAELH NAVKQLHSYG YKGLTNEALN VTLVEAGERI LPALPPRISA AAHNELTKLG 240
  241 VRVLTQTMVT SADEGGLHTK DGEYIEADLM VWAAGIKAPD FLKDIGGLET NRINQLVVEP 300
  301 TLQTTRDPDI YAIGDCASCP RPEGGFVPPR AQAAHQMATC AMNNILAQMN GKPLKNYQYK 360
  361 DHGSLVSLSN FSTVGSLMGN LTRGSMMIEG RIARFVYISL YRMHQIALHG YFKTGLMMLV 420
  421 GSINRVIRPR LKLH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	72.154902
Match:	1lpfA
Description:	Dihydrolipoamide dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on NADH or NADPH	7.86778387378753	bayes_pls_golite062009
oxidoreductase activity	4.83215507169904	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	4.19923051777224	bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity	4.08166950447814	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	4.05603184984386	bayes_pls_golite062009
NADH dehydrogenase activity	3.68406278988218	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	3.50748163367583	bayes_pls_golite062009
cation transmembrane transporter activity	3.32472671529283	bayes_pls_golite062009
ion transmembrane transporter activity	3.16108349803474	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	2.95007671227328	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.81614304979011	bayes_pls_golite062009
substrate-specific transporter activity	2.67270952915475	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	2.61710146943904	bayes_pls_golite062009
catalytic activity	2.35839632763616	bayes_pls_golite062009
protein binding	1.21627488765992	bayes_pls_golite062009
binding	1.07739303382566	bayes_pls_golite062009
oxygen-dependent protoporphyrinogen oxidase activity	0.84508368783381	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	0.7227919966299	bayes_pls_golite062009
NADPH-adrenodoxin reductase activity	0.689874846468951	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.421557797391339	bayes_pls_golite062009
glutathione-disulfide reductase activity	0.33334782799369	bayes_pls_golite062009
lipoamide binding	0.193025676337591	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	0.18455498413733	bayes_pls_golite062009
succinate dehydrogenase activity	0.110826254138262	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: