YRC Public Data Repository - Protein Structure Prediction

Protein:	GCSH_ECOLI
Organism:	Escherichia coli
Length:	129 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GCSH_ECOLI.

Description	E-value	Query Range	Subject Range
GCSH_SHEAM - Glycine cleavage system H protein OS=Shewanella amazonensis (strain ATCC BAA-1098 / SB2B) GN=gcvH PE...	189.0	[0..1]	[129..1]
GCSH_SYMTH - Glycine cleavage system H protein OS=Symbiobacterium thermophilum GN=gcvH PE=3 SV=1 GCSH_SYMTH - Glycine cleavage system H protein OS=Symbiobacterium thermophilum (strain T / IAM 14863) GN=gcvH PE=...	187.0	[0..1]	[128..1]
GCSH_SHELP - Glycine cleavage system H protein OS=Shewanella loihica (strain ATCC BAA-1088 / PV-4) GN=gcvH PE=3 S...	186.0	[0..1]	[129..1]
GCSH_ALTMD - Glycine cleavage system H protein OS=Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 2... GCSH_ALTMD - Glycine cleavage system H protein OS=Alteromonas macleodii (strain DSM 17117 / Deep ecotype) GN=gcvH...	184.0	[0..1]	[129..1]
gi\|68229731, gi\|... - gi\|68229731\|ref\|ZP_00568923.1\| Glycine cleavage H-protein [Frankia sp. EAN1pec], gi\|68202722\|gb\|EAN1...	184.0	[0..5]	[129..70]
GCSH_SHESA - Glycine cleavage system H protein OS=Shewanella sp. (strain ANA-3) GN=gcvH PE=3 SV=1 SO0780 - glycine cleavage system H protein GCSH_SHESM - Glycine cleavage system H protein OS=Shewanella sp. (strain MR-4) GN=gcvH PE=3 SV=1 GCSH_SHEON - Glycine cleavage system H protein OS=Shewanella oneidensis (strain MR-1) GN=gcvH PE=3 SV=1	184.0	[0..1]	[129..1]
GCSH_CHRVO - Glycine cleavage system H protein OS=Chromobacterium violaceum GN=gcvH PE=3 SV=1 GCSH_CHRVO - Glycine cleavage system H protein OS=Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM ...	184.0	[0..1]	[126..1]
gi\|91212282, gi\|... - gi\|91212282\|ref\|YP_542268.1\| glycine cleavage system protein H [Escherichia coli UTI89], gi\|91073856... gi\|26109727, gi\|... - gi\|26249319\|ref\|NP_755359.1\| glycine cleavage system protein H [Escherichia coli CFT073], gi\|2610972...	184.0	[0..1]	[129..2]
GCSH_ECOL6 - Glycine cleavage system H protein OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=... GCSH_ECOL6 - Glycine cleavage system H protein OS=Escherichia coli O6 GN=gcvH PE=3 SV=3 GCSH_ECOK1 - Glycine cleavage system H protein OS=Escherichia coli O1:K1 / APEC GN=gcvH PE=3 SV=1 GCSH_ECO81 - Glycine cleavage system H protein OS=Escherichia coli O81 (strain ED1a) GN=gcvH PE=3 SV=1 GCSH_ECO45 - Glycine cleavage system H protein OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=gcvH PE=3 SV=1 gi\|227888453, gi... - gi\|227888453\|ref\|ZP_04006258.1\| glycine cleavage system protein H [Escherichia coli 83972], gi\|22783... gi\|237706452, gi... - gi\|237706452\|ref\|ZP_04536933.1\| glycine cleavage system protein H [Escherichia sp. 3_2_53FAA], gi\|22...	184.0	[0..1]	[129..1]
GCSH_SALTY - Glycine cleavage system H protein OS=Salmonella typhimurium GN=gcvH PE=3 SV=3 GCSH_SALTY - Glycine cleavage system H protein OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN... GCSH_SALTY - Glycine cleavage system H protein OS=Salmonella typhimurium GN=gcvH PE=3 SV=3 GCSH_SALCH - Glycine cleavage system H protein OS=Salmonella choleraesuis GN=gcvH PE=3 SV=1 lcl\|NC_016856.1_... - [gene=gcvH] [protein=glycine cleavage system protein H] [protein_id=YP_005239191.1] [location=comple... GCSH_SALCH - Glycine cleavage system H protein OS=Salmonella choleraesuis (strain SC-B67) GN=gcvH PE=3 SV=1 GCSH_SALCH - Glycine cleavage system H protein OS=Salmonella choleraesuis GN=gcvH PE=3 SV=1 gi\|167994119, gi... - gi\|205327976\|gb\|EDZ14740.1\| glycine cleavage system H protein [Salmonella enterica subsp. enterica s... gi\|197265546, gi... - gi\|197265546\|ref\|ZP_03165620.1\| glycine cleavage system H protein [Salmonella enterica subsp. enteri... GCSH_SALPC - Glycine cleavage system H protein OS=Salmonella paratyphi C (strain RKS4594) GN=gcvH PE=3 SV=1	184.0	[0..1]	[129..1]

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Predicted Domain #1

Region A:
Residues: [1-129]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNVPAELKY SKEHEWLRKE ADGTYTVGIT EHAQELLGDM VFVDLPEVGA TVSAGDDCAV  60
   61 AESVKAASDI YAPVSGEIVA VNDALSDSPE LVNSEPYAGG WIFKIKASDE SELESLLDAT 120
  121 AYEALLEDE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.221849
Match:	1dxmA
Description:	Protein H of glycine cleavage system
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
aminomethyltransferase activity	7.15454688996532	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	6.56199545993139	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	6.56199545993139	bayes_pls_golite062009
acetyl-CoA carboxylase activity	2.30995434688093	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors	1.93346020821958	bayes_pls_golite062009
CoA carboxylase activity	1.92420834470262	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	1.62422217856347	bayes_pls_golite062009
catalytic activity	1.39099902011318	bayes_pls_golite062009
ligase activity	0.56894584941056	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: