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View Structure Prediction Details

Protein: FOLD_ECOLI
Organism: Escherichia coli
Length: 288 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FOLD_ECOLI.

Description E-value Query
Range		 Subject
Range
FOLD_MOOTA - Bifunctional protein FolD OS=Moorella thermoacetica (strain ATCC 39073) GN=folD PE=3 SV=1
 359.0 [0..1] [281..1]
FOLD_MAGMM - Bifunctional protein FolD OS=Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1) GN=folD...
sp|A0LE04|FOLD_MAGMM - Bifunctional protein FolD OS=Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1) GN=folD...
 354.0 [0..3] [284..2]
SO1792 - methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase
FOLD_SHEON - Bifunctional protein FolD OS=Shewanella oneidensis (strain MR-1) GN=folD PE=3 SV=1
 350.0 [0..1] [284..1]
FOLD_PSEF5 - Bifunctional protein FolD OS=Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) GN=folD PE=3 SV=1
 347.0 [0..1] [280..1]
FOLD_PSEPF - Bifunctional protein FolD OS=Pseudomonas fluorescens (strain Pf0-1) GN=folD PE=3 SV=1
 347.0 [0..1] [280..1]
gi|83837979, gi|... - gi|83950080|ref|ZP_00958813.1| folD bifunctional protein [Roseovarius nubinhibens ISM], gi|83837979|...
 347.0 [0..1] [287..1]
gi|114550889, gi... - gi|114778854|ref|ZP_01453653.1| 5,10-methylene-tetrahydrofolate dehydrogenase/cyclohydrolase [Maripr...
 347.0 [0..2] [285..5]
FOLD_SHESR - Bifunctional protein FolD OS=Shewanella sp. (strain MR-7) GN=folD PE=3 SV=1
 346.0 [0..1] [284..1]
FOLD_SHESM - Bifunctional protein FolD OS=Shewanella sp. (strain MR-4) GN=folD PE=3 SV=1
FOLD_SHESA - Bifunctional protein FolD OS=Shewanella sp. (strain ANA-3) GN=folD PE=3 SV=1
 346.0 [0..1] [284..1]
gi|95109995 - gi|95109995|emb|CAK14700.1| bifunctional protein [Includes: 5,10-methylene-tetrahydrofolate dehydrog...
FOLD_PSEE4 - Bifunctional protein FolD OS=Pseudomonas entomophila (strain L48) GN=folD PE=3 SV=1
 346.0 [0..1] [284..1]

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Predicted Domain #1
Region A:
Residues: [1-288] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAKIIDGKT IAQQVRSEVA QKVQARIAAG LRAPGLAVVL VGSNPASQIY VASKRKACEE  60
   61 VGFVSRSYDL PETTSEAELL ELIDTLNADN TIDGILVQLP LPAGIDNVKV LERIHPDKDV 120
  121 DGFHPYNVGR LCQRAPRLRP CTPRGIVTLL ERYNIDTFGL NAVVIGASNI VGRPMSMELL 180
  181 LAGCTTTVTH RFTKNLRHHV ENADLLIVAV GKPGFIPGDW IKEGAIVIDV GINRLENGKV 240
  241 VGDVVFEDAA KRASYITPVP GGVGPMTVAT LIENTLQACV EYHDPQDE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 94.09691
Match: 1b0aA
Description: Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity 3.54983447672782 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 2.66605122152932 bayes_pls_golite062009
malate dehydrogenase activity 2.43636049081724 bayes_pls_golite062009
catalytic activity 2.0643953589843 bayes_pls_golite062009
transcription regulator activity 1.95832530533882 bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity 1.95551536198286 bayes_pls_golite062009
DNA binding 1.70073234884672 bayes_pls_golite062009
binding 1.57522146187634 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.54527841865655 bayes_pls_golite062009
nucleic acid binding 1.47211855405194 bayes_pls_golite062009
malic enzyme activity 1.39067036188188 bayes_pls_golite062009
transcription factor activity 0.9895904275677 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor 0.66392365734856 bayes_pls_golite062009
cyclohydrolase activity 0.129148522173579 bayes_pls_golite062009
ligase activity 0.0191278372003161 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle