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View Structure Prediction Details

Protein: gi|20502828
Organism: Plasmodium falciparum
Length: 853 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|20502828.

Description E-value Query
Range
Subject
Range
gi|20378272 - gi|20378272|gb|AAM20901.1|AF413570_1 cGMP-dependent protein kinase [Toxoplasma gondii]
655.0 [0..2] [853..133]
gi|56501237 - gi|56501237|emb|CAH98038.1| cGMP-dependent protein kinase 1, beta isozyme, putative [Plasmodium berg...
gi|68076807 - gi|68076807|ref|XP_680323.1| cGMP-dependent protein kinase 1, beta isozyme [Plasmodium berghei strai...
654.0 [0..11] [853..1]
gi|20502826 - gi|20502826|gb|AAM22643.1|AF465543_1 cGMP-dependent protein kinase [Eimeria maxima]
650.0 [0..2] [853..122]
gi|20378270 - gi|20378270|gb|AAM20900.1|AF411961_1 cGMP-dependent protein kinase [Eimeria tenella]
639.0 [0..8] [853..123]
gi|23489825 - gi|23489825|gb|EAA21741.1| cGMP-dependent protein kinase-related [Plasmodium yoelii yoelii]
gi|83286472 - gi|83286472|ref|XP_730176.1| cGMP-dependent protein kinase [Plasmodium yoelii yoelii str. 17XNL]
597.0 [0..91] [853..6]
gi|65303352 - gi|65303352|emb|CAI75730.1| cGMP-dependent protein kinase, putative [Theileria annulata]
gi|85000975 - gi|85000975|ref|XP_955206.1| cGMP-dependent protein kinase [Theileria annulata strain Ankara]
580.0 [0..1] [853..24]
gi|71027791 - gi|71027791|ref|XP_763539.1| cGMP-dependent protein kinase [Theileria parva strain Muguga]
gi|68350492 - gi|68350492|gb|EAN31256.1| cGMP-dependent protein kinase, putative [Theileria parva]
568.0 [0..1] [825..24]
gi|66359614 - gi|66359614|ref|XP_626985.1| cyclic nucleotide (cGMP)-dependent protein kinase with 3 cNMP binding d...
gi|20378274, gi|... - gi|46228436|gb|EAK89306.1| cyclic nucleotide (cGMP)-dependent protein kinase with 3 cNMP binding dom...
563.0 [0..28] [848..79]
gi|67593668 - gi|67593668|ref|XP_665742.1| cGMP-dependent protein kinase [Cryptosporidium hominis TU502]
gi|54656557 - gi|54656557|gb|EAL35511.1| cGMP-dependent protein kinase [Cryptosporidium hominis]
560.0 [0..28] [848..6]

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Predicted Domain #1
Region A:
Residues: [1-299]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEEDDNLKKG NERNKKKAIF SNDDFTGEDS LMEDHLELRE KLSEDIDMIK TSLKNNLVCS  60
   61 TLNDNEILTL SNYMQFFVFK SGNLVIKQGE KGSYFFIINS GKFDVYVNDK KVKTMGKGSS 120
  121 FGEAALIHNT QRSATIIAET DGTLWGVQRS TFRATLKQLS NRNFNENRTF IDSVSVFDML 180
  181 TEAQKNMITN ACVIQNFKSG ETIVKQGDYG DVLYILKEGK ATVYINDEEI RVLEKGSYFG 240
  241 ERALLYDEPR SATIIAKEPT ACASICRKLL NIVLGNLQVV LFRNIMTEAL QQSEIFKQF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 82.39794
Match: 1rgsA
Description: REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [300-539]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGDQLNDLAD TAIVRDYPAN YNILHKDKVK SVKYIIVLEG KVELFLDDTS IGILSRGMSF  60
   61 GDQYVLNQKQ PFKHTIKSLE VCKIALITET CLADCLGNNN IDASIDYNNK KSIIKKMYIF 120
  121 RYLTDKQCNL LIEAFRTTRY EEGDYIIQEG EVGSRFYIIK NGEVEIVKNK KRLRTLGKND 180
  181 YFGERALLYD EPRTASVISK VNNVECWFVD KSVFLQIIQG PMLAHLEERI KMQDTKVEMD 240
  241 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.221849
Match: 1lckA
Description: p56-lck tyrosine kinase, SH3 domain; p56-lck tyrosine kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 4.41722924924158 bayes_pls_golite062009
actin binding 3.91045208670052 bayes_pls_golite062009
binding 3.12724619324809 bayes_pls_golite062009
actin filament binding 2.72908433443928 bayes_pls_golite062009
protein binding 2.14586566310919 bayes_pls_golite062009
insulin receptor binding 2.1238568876176 bayes_pls_golite062009
protein kinase activity 1.4654611643382 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.39494498759145 bayes_pls_golite062009
molecular adaptor activity 1.33740973673697 bayes_pls_golite062009
kinase activity 1.31102709888086 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.27380124084989 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.2323381312171 bayes_pls_golite062009
molecular transducer activity 0.999269271132931 bayes_pls_golite062009
signal transducer activity 0.999269271132931 bayes_pls_golite062009
structural molecule activity 0.989403012920596 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.950445630788802 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
protein complex binding 0.76378777571169 bayes_pls_golite062009
transcription regulator activity 0.540818657754841 bayes_pls_golite062009
structural constituent of muscle 0.52430033936893 bayes_pls_golite062009
transferase activity 0.4880159130787 bayes_pls_golite062009
nucleic acid binding 0.476094076158571 bayes_pls_golite062009
transporter activity 0.373683990992143 bayes_pls_golite062009
structural constituent of cytoskeleton 0.371928447183203 bayes_pls_golite062009
DNA binding 0.281643350069021 bayes_pls_golite062009
transmembrane transporter activity 0.151158240426264 bayes_pls_golite062009
kinase regulator activity 0.10704587503284 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [540-775]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELETERIIGR GTFGTVKLVH HKPTKIRYAL KCVSKRSIIN LNQQNNIKLE REITAENDHP  60
   61 FIIRLVRTFK DSKYFYFLTE LVTGGELYDA IRKLGLLSKS QAQFYLGSII LAIEYLHERN 120
  121 IVYRDLKPEN ILLDKQGYVK LIDFGCAKKV QGRAYTLVGT PHYMAPEVIL GKGYGCTVDI 180
  181 WALGICLYEF ICGPLPFGND EEDQLEIFRD ILTGQLTFPD YVTDTDSINL MKRLLC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 66.522879
Match: 2fh9A
Description: No description for 2fh9A was found.

Predicted Domain #4
Region A:
Residues: [776-853]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLPQGRIGCS INGFKDIKDH PFFSNFNWDK LAGRLLDPPL VSKSETYAED IDIKQIEEED  60
   61 AEDDEEPLND EDNWDIDF

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.45
Match: 1fotA
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle