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View Structure Prediction Details

Protein: gi|23497139, gi|...
Organism: Plasmodium falciparum 3D7
Length: 449 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|23497139, gi|....

Description E-value Query
Range
Subject
Range
gi|58372433 - gi|58372433|gb|AAW71460.1| plasmepsin 4 [Plasmodium falciparum]
376.0 [0..1] [448..1]
gi|3095038 - gi|3095038|gb|AAC15794.1| plasmepsin [Plasmodium malariae]
367.0 [0..1] [448..1]
gi|114637864 - gi|114637864|ref|XP_001144824.1| PREDICTED: pepsinogen 5, group I (pepsinogen A) isoform 2 [Pan trog...
364.0 [0..78] [446..80]
gi|3095036 - gi|3095036|gb|AAC15793.1| plasmepsin [Plasmodium ovale]
361.0 [0..1] [448..1]
gi|46488407, gi|... - gi|46488411|gb|AAS99527.1| aspartic protease PM4 [Plasmodium vivax], gi|46488409|gb|AAS99526.1| aspa...
360.0 [0..1] [448..1]
gi|116284100 - gi|116284100|gb|AAI23963.1| LOC613063 protein [Xenopus tropicalis]
359.0 [0..82] [447..21]
gi|118344558, gi... - gi|55771082|dbj|BAD69801.1| cathepsin D1 [Takifugu rubripes], gi|118344558|ref|NP_001072052.1| cathe...
358.0 [0..82] [447..21]

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Predicted Domain #1
Region A:
Residues: [1-117]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALTVKEEEF SNTLIKNASA FDRLKLGNLK NLKIQKKLQF LYLILFVLIT GVFFFFLIGN  60
   61 FYSHRKLYQV IKNTKHTTIG FKIDRPHDKV LSSVLKNKLS TYVKESFKFF KSGYAQK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.84
Match: 2bjuA
Description: Plasmepsin II complexed with a highly active achiral inhibitor
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [118-449]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYLGSENDSI ELDDVANLMF YGEGQIGTNK QPFMFIFDTG SANLWVPSVN CDSIGCSTKH  60
   61 LYDASASKSY EKDGTKVEIS YGSGTVRGYF SKDVISLGDL SLPYKFIEVT DADDLEPIYS 120
  121 GSEFDGILGL GWKDLSIGSI DPVVVELKKQ NKIDNALFTF YLPVHDKHVG YLTIGGIESD 180
  181 FYEGPLTYEK LNHDLYWQID LDIHFGKYVM QKANAVVDSG TSTITAPTSF LNKFFRDMNV 240
  241 IKVPFLPLYV TTCDNDDLPT LEFHSRNNKY TLEPEFYMDP LSDIDPALCM LYILPVDIDD 300
  301 NTFILGDPFM RKYFTVFDYE KESVGFAVAK NL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.69897
Match: 1ls5A
Description: Plasmepsin (a hemoglobin-degrading enzyme)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
aspartic-type endopeptidase activity 7.9145950161796 bayes_pls_golite062009
aspartic-type peptidase activity 7.9145950161796 bayes_pls_golite062009
peptidase activity 3.72944613332838 bayes_pls_golite062009
endopeptidase activity 3.63710372612656 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.48908213679821 bayes_pls_golite062009
hydrolase activity 2.83913600343968 bayes_pls_golite062009
catalytic activity 1.54514410489082 bayes_pls_golite062009
binding 1.10054369202721 bayes_pls_golite062009
receptor binding 0.561225023505917 bayes_pls_golite062009
protein binding 0.193907750061394 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle