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View Structure Prediction Details

Protein: gi|4377730
Organism: Plasmodium falciparum
Length: 389 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|4377730.

Description E-value Query
Range
Subject
Range
gi|25290301 - pir||AG2466 GTP cyclohydrolase I [imported] - Nostoc sp. (strain PCC 7120)
GCH11_NOSS1 - GTP cyclohydrolase 1 1 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=folE1 PE=3 SV=1
319.0 [0..174] [388..19]
gi|75702476, gi|... - gi|75908751|ref|YP_323047.1| GTP cyclohydrolase I [Anabaena variabilis ATCC 29413], gi|75702476|gb|A...
319.0 [0..168] [388..13]
GCH1_SYNEL - GTP cyclohydrolase 1 OS=Synechococcus elongatus GN=folE PE=3 SV=1
GCH1_THEEB - GTP cyclohydrolase 1 OS=Thermosynechococcus elongatus (strain BP-1) GN=folE PE=3 SV=1
316.0 [0..181] [389..22]
GCH1_NOSP7 - GTP cyclohydrolase 1 OS=Nostoc punctiforme (strain ATCC 29133 / PCC 73102) GN=folE PE=3 SV=1
310.0 [0..160] [388..5]
gi|22002492 - gi|22002492|gb|AAM82644.1| Gch1 [Synechococcus sp. PCC 7942]
310.0 [0..174] [388..3]
GCH1_SYNE7 - GTP cyclohydrolase 1 OS=Synechococcus elongatus (strain PCC 7942) GN=folE PE=3 SV=2
GCH1_SYNP6 - GTP cyclohydrolase 1 OS=Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) GN=folE PE=3 ...
310.0 [0..178] [388..1]
gi|48894796, gi|... - gi|71676081|ref|ZP_00673824.1| GTP cyclohydrolase I [Trichodesmium erythraeum IMS101], gi|71670942|g...
302.0 [0..178] [389..1]
GCH1_GLOVI - GTP cyclohydrolase 1 OS=Gloeobacter violaceus GN=folE PE=3 SV=1
GCH1_GLOVI - GTP cyclohydrolase 1 OS=Gloeobacter violaceus (strain PCC 7421) GN=folE PE=3 SV=1
300.0 [0..203] [388..29]

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Predicted Domain #1
Region A:
Residues: [1-165]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYKYTSINKS DKIYETHNME EKKKKGNNNN FSGLLNNEID DNNKKEKLKN SISKMYSNHK  60
   61 NRENFNECEK EDLVVIDEKD NNKKKKKNMT NTFEQDNNYN MNDNKRLGSF FKINDKCESI 120
  121 NENVNNINKQ SLKDSILFDN INEKEYFNET KEENKEGNKS NDIEK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [166-389]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INCMKVKKKT VKKNKKKINK IINNKNKISK SNDIEEQIIN ISKHIYKILN ISKLPKCDIL  60
   61 KRTNRRYAET FLYLTNGYNL DIEQIIKRSL YKRMYKNNSI IKVTGIHIYS LCKHHLLPFE 120
  121 GTCDIEYIPN KYIIGLSKFS RIVDVFSRRL QLQEDLTNDI CNALKKYLKP LYIKVSIVAK 180
  181 HLCINMRGVK EHDAKTITYA SYKAEKENPT VHSLNIDSSV ENLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 80.154902
Match: 1is7A
Description: GTP cyclohydrolase I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
GTP cyclohydrolase I activity 4.32142445441644 bayes_pls_golite062009
cyclohydrolase activity 4.12134839958676 bayes_pls_golite062009
GTP cyclohydrolase activity 3.76376266092452 bayes_pls_golite062009
catalytic activity 2.57832156213163 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 2.13367928146634 bayes_pls_golite062009
dihydroneopterin aldolase activity 2.05627605013559 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1.46072575729571 bayes_pls_golite062009
6-pyruvoyltetrahydropterin synthase activity 0.11818000438771 bayes_pls_golite062009
lyase activity 0.0597333135477298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle