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View Structure Prediction Details

Protein: gi|13093995, gi|...
Organism: Mycobacterium leprae
Length: 563 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|13093995, gi|....

Description E-value Query
Range
Subject
Range
gi|88945102, gi|... - gi|88945102|ref|ZP_01148322.1| Uroporphyrin-III C-methyltransferase, C-terminal [Desulfotomaculum re...
412.0 [0..11] [548..1]
gi|71489436, gi|... - gi|71544542|ref|ZP_00665566.1| Uroporphyrin-III C-methyltransferase, C-terminal [Syntrophobacter fum...
407.0 [0..13] [554..1]
gi|51245586, gi|... - gi|51245586|ref|YP_065470.1| uroporphyrinogen III synthase/methyltransferase (HemD+CobA) [Desulfotal...
405.0 [0..6] [548..1]
gi|109645297, gi... - gi|68208394|ref|ZP_00560513.1| Uroporphyrin-III C-methyltransferase, C-terminal [Desulfitobacterium ...
405.0 [0..13] [542..1]
gi|48845542, gi|... - gi|78224426|ref|YP_386173.1| uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferas...
404.0 [0..8] [548..1]
gi|89894970, gi|... - gi|89894970|ref|YP_518457.1| hypothetical protein DSY2224 [Desulfitobacterium hafniense Y51], gi|893...
400.0 [0..13] [542..1]
gi|94730811, gi|... - gi|94986562|ref|YP_594495.1| siroheme synthase [Lawsonia intracellularis PHE/MN1-00], gi|94730811|em...
399.0 [0..17] [546..2]
gi|91201153 - gi|91201153|emb|CAJ74212.1| strongly similar to uroporphyrinogen III synthase/methyltransferase [Can...
399.0 [0..13] [543..1]
gi|23473894, gi|... - gi|78357878|ref|YP_389327.1| uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferas...
397.0 [0..17] [547..2]
gi|41410102, gi|... - gi|41410102|ref|NP_962938.1| hypothetical protein MAP4004 [Mycobacterium avium subsp. paratuberculos...
396.0 [0..6] [563..1]

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Predicted Domain #1
Region A:
Residues: [1-288]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVGATMTTRG RKLRPGRITF VGAGPGAPGL LTAQAVAVLA NAALVFIDPD VPEPVLALIG  60
   61 KDLPPVSGPA PAGPAAVTAG RAADGTLEGD HYQAAPMVMS GGADIRPALG DPTEVAKTLT 120
  121 AEARSGVDVV RLVAGDPLTV DAVIAEVNAV ARTNLQIEIV PGLVTSSVVP TYAGLPLGSS 180
  181 HTVADVRGDV DWEALAAAPG PLILQATASH LADAAHILID HGLDDATPCV VTAQGTTCQQ 240
  241 RSVETTLEGL ADSAVLVGTD TAGPLTGPLV VTIGKTVTSR ARLNWWES

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.69897
Match: 1pjqA
Description: Structure and function of CysG, the multifunctional methyltransferase/dehydrogenase/ferrochelatase for siroheme synthesis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
uroporphyrin-III C-methyltransferase activity 3.70810184740502 bayes_pls_golite062009
C-methyltransferase activity 3.49766011792986 bayes_pls_golite062009
precorrin-2 dehydrogenase activity 2.67806035597297 bayes_pls_golite062009
sirohydrochlorin ferrochelatase activity 2.40719502419427 bayes_pls_golite062009
catalytic activity 1.85393572319476 bayes_pls_golite062009
transferase activity 1.11319893632325 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 0.934144410066549 bayes_pls_golite062009
precorrin-4 C11-methyltransferase activity 0.920471789208861 bayes_pls_golite062009
methyltransferase activity 0.915475179027344 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 0.637525028271766 bayes_pls_golite062009
ferrochelatase activity 0.15375007777431 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [289-563]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RALYGWTVLV PRTKDQAGEM SERLTSYGAL PVEVPTIAVE PPRSPAQMER AVKGLVDGRF  60
   61 QWVVFTSTNA VRAVWEKFGE FGLDARAFSG VKIACVGEAT ADRVRAFGIS PELVPAGEQS 120
  121 SLGLLDEFPP YDSVFDPVNR VLLPRADIAT ETLAEGLRGC GWEIEDVTAY RTVRAAPPPA 180
  181 ATREMIKTGG FDAVCFTSSS TVRNLVGIAG KPHARTVIAC IGPKTAETAS EFGLRVDVQP 240
  241 ETAAVGPLVD ALAEHVARLR AEGALPPPRK KSRRR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.221849
Match: 1jr2A
Description: Uroporphyrinogen III synthase (U3S, HemD)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
uroporphyrinogen-III synthase activity 3.19339392327514 bayes_pls_golite062009
catalytic activity 1.50868196926865 bayes_pls_golite062009
hydro-lyase activity 0.850411184249311 bayes_pls_golite062009
lyase activity 0.0536528882085157 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle