YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|16761859
Organism:	Salmonella enterica subsp. enterica serovar Typhi str. CT18
Length:	663 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|16761859.

Description	E-value	Query Range	Subject Range
gi\|91073890, gi\|... - gi\|91212316\|ref\|YP_542302.1\| transketolase 1 [Escherichia coli UTI89], gi\|91073890\|gb\|ABE08771.1\| tr... gi\|237706414, gi... - gi\|237706414\|ref\|ZP_04536895.1\| transketolase 1 [Escherichia sp. 3_2_53FAA], gi\|226899454\|gb\|EEH8571...	0.0	[1..663]	[11..673]
gi\|162138379 - gi\|162138379\|ref\|YP_542302.2\| transketolase [Escherichia coli UTI89] gi\|218559926, gi... - gi\|218559926\|ref\|YP_002392839.1\| transketolase [Escherichia coli S88], gi\|218366695\|emb\|CAR04452.1\| ... gi\|117625164, gi... - gi\|117625164\|ref\|YP_854152.1\| transketolase [Escherichia coli APEC O1], gi\|115514288\|gb\|ABJ02363.1\| ...	0.0	[1..663]	[1..663]
gi\|33358168, gi\|... - gi\|33358168\|pdb\|1QGD\|B Chain B, Transketolase From Escherichia Coli, gi\|33358167\|pdb\|1QGD\|A Chain A,...	0.0	[5..663]	[4..662]
gi\|75178838, gi\|... - gi\|75178838\|ref\|ZP_00698874.1\| COG0021: Transketolase [Shigella boydii BS512], gi\|187733279\|ref\|YP_0...	0.0	[1..663]	[1..663]
gi\|26249355, gi\|... - gi\|26249355\|ref\|NP_755395.1\| transketolase [Escherichia coli CFT073], gi\|26109763\|gb\|AAN81968.1\|AE01...	0.0	[1..663]	[11..673]
gi\|110344676, gi... - gi\|110643084\|ref\|YP_670814.1\| transketolase [Escherichia coli 536], gi\|110344676\|gb\|ABG70913.1\| tran... gi\|75241267, gi\|... - gi\|75241267\|ref\|ZP_00725129.1\| COG0021: Transketolase [Escherichia coli F11], gi\|191171823\|ref\|ZP_03... gi\|227834758, gi... - gi\|227888489\|ref\|ZP_04006294.1\| transketolase [Escherichia coli 83972], gi\|227834758\|gb\|EEJ45224.1\| ... gi\|218691058, gi... - gi\|218691058\|ref\|YP_002399270.1\| transketolase [Escherichia coli ED1a], gi\|218428622\|emb\|CAR09551.2\|...	0.0	[1..663]	[1..663]
gi\|208727518, gi... - gi\|208807717\|ref\|ZP_03250054.1\| transketolase [Escherichia coli O157:H7 str. EC4206], gi\|208727518\|g... gi\|195936556 - gi\|195936556\|ref\|ZP_03081938.1\| transketolase [Escherichia coli O157:H7 str. EC4024] gi\|208738906, gi... - gi\|208818783\|ref\|ZP_03259103.1\| transketolase [Escherichia coli O157:H7 str. EC4042], gi\|208738906\|g... gi\|208812817, gi... - gi\|208812817\|ref\|ZP_03254146.1\| transketolase [Escherichia coli O157:H7 str. EC4045], gi\|208734094\|g... gi\|217320116, gi... - gi\|217327749\|ref\|ZP_03443832.1\| transketolase [Escherichia coli O157:H7 str. TW14588], gi\|217320116\|... gi\|209161704, gi... - gi\|209400304\|ref\|YP_002272414.1\| transketolase [Escherichia coli O157:H7 str. EC4115], gi\|209161704\|... gi\|13363282, gi\|... - gi\|15833064\|ref\|NP_311837.1\| transketolase [Escherichia coli O157:H7 str. Sakai], gi\|13363282\|dbj\|BA... gi\|254594286, gi... - gi\|254794886\|ref\|YP_003079723.1\| transketolase 1, thiamin-binding [Escherichia coli O157:H7 str. TW1... gi\|188017797, gi... - gi\|188017797\|gb\|EDU55919.1\| transketolase [Escherichia coli O157:H7 str. EC4113], gi\|168747576\|ref\|Z... gi\|157155441, gi... - gi\|75187654\|ref\|ZP_00700921.1\| COG0021: Transketolase [Escherichia coli E24377A], gi\|157155441\|ref\|Y... gi\|189369283, gi... - gi\|189369283\|gb\|EDU87699.1\| transketolase [Escherichia coli O157:H7 str. EC4501], gi\|168760073\|ref\|Z... gi\|189358659, gi... - gi\|189358659\|gb\|EDU77078.1\| transketolase [Escherichia coli O157:H7 str. EC4401], gi\|168753883\|ref\|Z... gi\|81246852, gi\|... - gi\|82545441\|ref\|YP_409388.1\| transketolase [Shigella boydii Sb227], gi\|81246852\|gb\|ABB67560.1\| trans... gi\|187770781, gi... - gi\|187770781\|gb\|EDU34625.1\| transketolase [Escherichia coli O157:H7 str. EC4196], gi\|168773429\|ref\|Z... gi\|189363681, gi... - gi\|189363681\|gb\|EDU82100.1\| transketolase [Escherichia coli O157:H7 str. EC4486], gi\|168766938\|ref\|Z... gi\|75239493, gi\|... - gi\|75239493\|ref\|ZP_00723464.1\| COG0021: Transketolase [Escherichia coli E110019], gi\|193067298\|ref\|Z... gi\|189374031, gi... - gi\|189374031\|gb\|EDU92447.1\| transketolase [Escherichia coli O157:H7 str. EC869], gi\|168785789\|ref\|ZP... gi\|74313492, gi\|... - gi\|74313492\|ref\|YP_311911.1\| transketolase [Shigella sonnei Ss046], gi\|73856969\|gb\|AAZ89676.1\| trans... gi\|168781790, gi... - gi\|189000631\|gb\|EDU69617.1\| transketolase [Escherichia coli O157:H7 str. EC4076], gi\|168781790\|ref\|Z... gi\|25286310, gi\|... - pir\|\|B91105 transketolase 1 isozyme [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0... gi\|13363282, gi\|... - gi\|15833064\|ref\|NP_311837.1\| transketolase [Escherichia coli O157:H7], gi\|13363282\|dbj\|BAB37233.1\| t...	0.0	[1..663]	[1..663]
gi\|238902057, gi... - gi\|238902057\|ref\|YP_002927853.1\| transketolase 1, thiamin-binding [Escherichia coli BW2952], gi\|2388... gi\|254289605, gi... - gi\|254289605\|ref\|YP_003055353.1\| transketolase 1, thiamin-binding [Escherichia coli BL21(DE3)], gi\|2... gi\|242378462, gi... - gi\|251786189\|ref\|YP_003000493.1\| hypothetical protein B21_02728 [Escherichia coli BL21], gi\|24237846... gi\|157068074, gi... - gi\|75196886\|ref\|ZP_00706956.1\| COG0021: Transketolase [Escherichia coli HS], gi\|157162394\|ref\|YP_001... gi\|209920394, gi... - gi\|209920394\|ref\|YP_002294478.1\| transketolase [Escherichia coli SE11], gi\|209913653\|dbj\|BAG78727.1\|... gi\|194424168, gi... - gi\|83587665\|ref\|ZP_00926292.1\| COG0021: Transketolase [Escherichia coli 101-1], gi\|194436686\|ref\|ZP_... gi\|215266304, gi... - gi\|215488232\|ref\|YP_002330663.1\| transketolase [Escherichia coli O127:H6 str. E2348/69], gi\|21526630... gi\|254162845, gi... - gi\|254162845\|ref\|YP_003045953.1\| transketolase 1, thiamin-binding [Escherichia coli B str. REL606], ... TKT1_ECOLI - Transketolase 1 (EC 2.2.1.1) (TK 1) - Escherichia coli gi\|85675745, gi\|... - gi\|89109712\|ref\|AP_003492.1\| transketolase 1, thiamin-binding [Escherichia coli str. K-12 substr. W3... gi\|169753749, gi... - gi\|170018821\|ref\|YP_001723775.1\| transketolase [Escherichia coli ATCC 8739], gi\|169753749\|gb\|ACA7644... gi\|188493673, gi... - gi\|75515282\|ref\|ZP_00737466.1\| COG0021: Transketolase [Escherichia coli 53638], gi\|188493673\|ref\|ZP_... gi\|170082489, gi... - gi\|170082489\|ref\|YP_001731809.1\| transketolase 1, thiamin-binding [Escherichia coli str. K-12 substr... gi\|218371632, gi... - gi\|218701646\|ref\|YP_002409275.1\| transketolase [Escherichia coli IAI39], gi\|218371632\|emb\|CAR19471.1... gi\|218433545, gi... - gi\|218706448\|ref\|YP_002413967.1\| transketolase [Escherichia coli UMN026], gi\|218433545\|emb\|CAR14448.... EG11427 - transketolase 1, thiamine triphosphate-binding / Transketolase A; binds Zn(II) gi\|218362254, gi... - gi\|218555486\|ref\|YP_002388399.1\| transketolase [Escherichia coli IAI1], gi\|218362254\|emb\|CAQ99875.1\|... gi\|124526162, gi... - gi\|124526162\|ref\|ZP_01698167.1\| transketolase [Escherichia coli B], gi\|124502266\|gb\|EAY49726.1\| tran... gi\|218696532, gi... - gi\|218696532\|ref\|YP_002404199.1\| transketolase [Escherichia coli 55989], gi\|218353264\|emb\|CAU99213.1... EG11427 - transketolase 1, thiamine triphosphate-binding / Transketolase A; binds Zn(II)	0.0	[1..663]	[1..663]
gi\|82778297, gi\|... - gi\|82778297\|ref\|YP_404646.1\| transketolase [Shigella dysenteriae Sd197], gi\|81242445\|gb\|ABB63155.1\| ...	0.0	[1..663]	[1..663]
gi\|168826063, gi... - gi\|32029978\|ref\|ZP_00132914.1\| COG0021: Transketolase [Haemophilus somnus 2336], gi\|170717934\|ref\|YP...	0.0	[5..663]	[5..668]

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Predicted Domain #1

Region A:
Residues: [1-663]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSRKELANA IRALSMDAVQ KAKSGHPGAP MGMADIAEVL WRDFLNHNPT NPSWADRDRF  60
   61 VLSNGHGSML IYSLLHLTGY DLPMSELQNF RQLHSKTPGH PEVGYTAGVE TTTGPLGQGI 120
  121 ANAVGMAIAE KTLAAQFNRP GHDIVDHFTY VFMGDGCMME GISHEVCSLA GTLKLGKLIA 180
  181 FYDDNGISID GHVEGWFTDD TAKRFEAYGW HVIRGIDGHD ADAIKRATEE ARAVTDKPSL 240
  241 LMCKTIIGFG SPNKQGTHDS HGAPLGDAEI ALTREQLGWK YAPFEIPSEI YAQWDAKEAG 300
  301 QAKESAWNEK FAAYEKAFPQ EAAEFTRRMK GDMPADFNAK ANEFIAKLQA NPSKIASRKA 360
  361 SQNAIEAFGP LLPEFLGGSA DLAPSNLTLW SGSKAINEDA AGNYIHYGVR EFGMTAIANG 420
  421 IALHGGFLPY TSTFLMFVEY ARNAVRMAAL MKQRQVMVYT HDSIGLGEDG PTHQPVEQVA 480
  481 SLRVTPNMST WRPCDQVESA VAWKYGVERQ DGPTALILSR QNLAQQERTE EQLANIARGG 540
  541 YVLKDCAGQP QIIFIATGSE VELAVAAYEK LTAEGVKARV VSMPSTDAFD KQDAAYRESV 600
  601 LPKAVSARVA IEAGIADYWF KYVGLNGAIV GMTTFGESAP AELLFEEFGF TVDNVIAKAK 660
  661 ALL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1qgdA
Description:	Transketolase (TK), Pyr module; Transketolase (TK), PP module; Transketolase (TK), C-domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transketolase activity	6.17852985073866	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	2.93250853993668	bayes_pls_golite062009
pyruvate dehydrogenase activity	2.81702263447118	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	2.6977837113283	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	2.21959520697519	bayes_pls_golite062009
binding	0.980920092099572	bayes_pls_golite062009
catalytic activity	0.545407789079971	bayes_pls_golite062009
thiamin pyrophosphate binding	0.297191393111081	bayes_pls_golite062009
acetolactate synthase activity	0.173822256668691	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: