YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|16759699
Organism:	Salmonella enterica subsp. enterica serovar Typhi str. CT18
Length:	382 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|16759699.

Description	E-value	Query Range	Subject Range
gi\|205327714, gi... - gi\|205327714\|gb\|EDZ14478.1\| galactokinase [Salmonella enterica subsp. enterica serovar 4,[5],12:i:- ... GAL1_SALTY - Galactokinase OS=Salmonella typhimurium GN=galK PE=3 SV=2 GAL1_SALNS - Galactokinase OS=Salmonella newport (strain SL254) GN=galK PE=3 SV=1 lcl\|NC_016856.1_... - [gene=galK] [protein=galactokinase] [protein_id=YP_005236493.1] [location=complement(838713..839861)... GAL1_SALTY - Galactokinase OS=Salmonella typhimurium GN=galK PE=3 SV=2 GAL1_SALTY - Galactokinase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=galK PE=3 SV=2	0.0	[1..382]	[1..382]
GAL1_SALPA - Galactokinase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=galK PE=3 SV=1 GAL1_SALPA - Galactokinase OS=Salmonella paratyphi A GN=galK PE=3 SV=1 GAL1_SALPK - Galactokinase OS=Salmonella paratyphi A (strain AKU_12601) GN=galK PE=3 SV=1	0.0	[1..382]	[1..382]
GAL1_SALCH - Galactokinase OS=Salmonella choleraesuis GN=galK PE=3 SV=1 GAL1_SALCH - Galactokinase OS=Salmonella choleraesuis GN=galK PE=3 SV=1 GAL1_SALCH - Galactokinase OS=Salmonella choleraesuis (strain SC-B67) GN=galK PE=3 SV=1	0.0	[1..382]	[1..382]
GAL1_ECOUT - Galactokinase OS=Escherichia coli (strain UTI89 / UPEC) GN=galK PE=3 SV=1 gi\|227884282, gi... - gi\|227884282\|ref\|ZP_04002087.1\| galactokinase [Escherichia coli 83972], gi\|227839034\|gb\|EEJ49500.1\| ... gi\|226898497, gi... - gi\|237707287\|ref\|ZP_04537768.1\| galactokinase [Escherichia sp. 3_2_53FAA], gi\|226898497\|gb\|EEH84756.... GAL1_ECO45 - Galactokinase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=galK PE=3 SV=1 GAL1_ECOL6 - Galactokinase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=galK PE=3 SV=3 gi\|75237093, gi\|... - gi\|75237093\|ref\|ZP_00721147.1\| COG0153: Galactokinase [Escherichia coli F11], gi\|191174194\|ref\|ZP_03... GAL1_ECOK1 - Galactokinase OS=Escherichia coli O1:K1 / APEC GN=galK PE=3 SV=1 GAL1_ECOL6 - Galactokinase OS=Escherichia coli O6 GN=galK PE=3 SV=3 GAL1_ECOL5 - Galactokinase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=galK PE=3 SV=1	1.0E-99	[1..382]	[1..382]
gi\|59803287 - gi\|59803287\|gb\|AAX07752.1\| galactokinase [Klebsiella pneumoniae] gi\|238893786, gi... - gi\|238893786\|ref\|YP_002918520.1\| galactokinase [Klebsiella pneumoniae NTUH-K2044], gi\|238546102\|dbj\|...	1.0E-99	[1..382]	[1..382]
gi\|86516614 - gi\|86516614\|gb\|ABC97999.1\| GalK [Shigella boydii]	2.0E-99	[1..382]	[1..382]
gi\|86516662 - gi\|86516662\|gb\|ABC98023.1\| GalK [Shigella dysenteriae]	2.0E-99	[1..382]	[1..382]
GAL1_ECO24 - Galactokinase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=galK PE=3 SV=1 gi\|75235774, gi\|... - gi\|75235774\|ref\|ZP_00719929.1\| COG0153: Galactokinase [Escherichia coli E110019], gi\|193069539\|ref\|Z... gi\|193065587, gi... - gi\|75256341\|ref\|ZP_00728011.1\| COG0153: Galactokinase [Escherichia coli E22], gi\|193065587\|ref\|ZP_03... gi\|595700 - gi\|595700\|gb\|AAA57082.1\| galactokinase [unidentified cloning vector] gi\|188493829, gi... - gi\|75511359\|ref\|ZP_00734044.1\| COG0153: Galactokinase [Escherichia coli 53638], gi\|188493829\|ref\|ZP_... gi\|58030, gi\|58033 - gi\|58033\|emb\|CAA47410.1\| galK gene from E.coli [synthetic construct], gi\|58030\|emb\|CAA47408.1\| galK ... GAL1_ECOLI - Galactokinase (EC 2.7.1.6) (Galactose kinase) - Escherichia coli GAL1_ECO57 - Galactokinase OS=Escherichia coli O157:H7 GN=galK PE=3 SV=2 GAL1_ECOBW - Galactokinase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=galK PE=3 SV=1 EG10363 - galactokinase / Galactokinase gi\|254160820, gi... - gi\|254160820\|ref\|YP_003043928.1\| galactokinase [Escherichia coli B str. REL606], gi\|253972721\|gb\|ACT... gi\|254591308, gi... - gi\|254791908\|ref\|YP_003076745.1\| galactokinase [Escherichia coli O157:H7 str. TW14359], gi\|254591308... gi\|194435024, gi... - gi\|83568959\|ref\|ZP_00920424.1\| COG0153: Galactokinase [Shigella dysenteriae 1012], gi\|194435024\|ref\|... gi\|194439764, gi... - gi\|83584858\|ref\|ZP_00923517.1\| COG0153: Galactokinase [Escherichia coli 101-1], gi\|194439764\|ref\|ZP_... EG10363 - galactokinase / Galactokinase gi\|89107608, gi\|... - gi\|89107608\|ref\|AP_001388.1\| galactokinase [Escherichia coli str. K-12 substr. W3110], gi\|1651342\|db... gi\|13360244, gi\|... - gi\|15830039\|ref\|NP_308812.1\| galactokinase [Escherichia coli O157:H7 str. Sakai], gi\|13360244\|dbj\|BA... gi\|86516626, gi\|... - gi\|86516638\|gb\|ABC98011.1\| GalK [Shigella boydii], gi\|86516634\|gb\|ABC98009.1\| GalK [Shigella boydii]... gi\|86516664 - gi\|86516664\|gb\|ABC98024.1\| GalK [Shigella dysenteriae] gi\|195936745 - gi\|195936745\|ref\|ZP_03082127.1\| galactokinase [Escherichia coli O157:H7 str. EC4024] gi\|168800811, gi... - gi\|189376968\|gb\|EDU95384.1\| galactokinase [Escherichia coli O157:H7 str. EC508], gi\|168800811\|ref\|ZP... gi\|208731433, gi... - gi\|208814785\|ref\|ZP_03255964.1\| galactokinase [Escherichia coli O157:H7 str. EC4045], gi\|208731433\|g... gi\|208727444, gi... - gi\|208807643\|ref\|ZP_03249980.1\| galactokinase [Escherichia coli O157:H7 str. EC4206], gi\|208727444\|g... GAL1_ECO5E - Galactokinase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=galK PE=3 SV=1 gi\|208737944, gi... - gi\|208822459\|ref\|ZP_03262778.1\| galactokinase [Escherichia coli O157:H7 str. EC4042], gi\|208737944\|g... GAL1_ECOLC - Galactokinase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=galK PE=3 SV=1 gi\|217321756, gi... - gi\|217325535\|ref\|ZP_03441619.1\| galactokinase [Escherichia coli O157:H7 str. TW14588], gi\|217321756\|... GAL1_ECOSE - Galactokinase OS=Escherichia coli (strain SE11) GN=galK PE=3 SV=1 gi\|188015487, gi... - gi\|188015487\|gb\|EDU53609.1\| galactokinase [Escherichia coli O157:H7 str. EC4113], gi\|168750249\|ref\|Z... gi\|168763347, gi... - gi\|189366430\|gb\|EDU84846.1\| galactokinase [Escherichia coli O157:H7 str. EC4501], gi\|168763347\|ref\|Z... gi\|189355897, gi... - gi\|189355897\|gb\|EDU74316.1\| galactokinase [Escherichia coli O157:H7 str. EC4401], gi\|168757046\|ref\|Z... gi\|187768179, gi... - gi\|187768179\|gb\|EDU32023.1\| galactokinase [Escherichia coli O157:H7 str. EC4196], gi\|168776498\|ref\|Z... gi\|189363413, gi... - gi\|189363413\|gb\|EDU81832.1\| galactokinase [Escherichia coli O157:H7 str. EC4486], gi\|168767202\|ref\|Z... gi\|189373137, gi... - gi\|189373137\|gb\|EDU91553.1\| galactokinase [Escherichia coli O157:H7 str. EC869], gi\|168786916\|ref\|ZP... gi\|189003027, gi... - gi\|189003027\|gb\|EDU72013.1\| galactokinase [Escherichia coli O157:H7 str. EC4076], gi\|168779245\|ref\|Z... gi\|124531874, gi... - gi\|124531874\|ref\|ZP_01701973.1\| galactokinase [Escherichia coli B], gi\|124498295\|gb\|EAY45813.1\| gala... GAL1_ECO55 - Galactokinase OS=Escherichia coli (strain 55989 / EAEC) GN=galK PE=3 SV=1 GAL1_ECO8A - Galactokinase OS=Escherichia coli O8 (strain IAI1) GN=galK PE=3 SV=1	2.0E-99	[1..382]	[1..382]

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Predicted Domain #1

Region A:
Residues: [1-382]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLKEKTRAL FAEIFGYPAT HTIQAPGRVN LIGEHTDYND GFVLPCAIDY QTVISCAPRD  60
   61 DRTVRVIAAD YDNQVDEFSL DAPIVTHDSQ QWSNYVRGVV KHLQQRNNAF GGVDMVISGN 120
  121 VPQGAGLSSS ASLEVAVGTV FQQLYHLPLD GAQIALNGQE AENQFVGCNC GIMDQLISAL 180
  181 GKKDHALLID CRTLGAKAVS MPKGVAVVII NSNFKRTLVG SEYNTRREQC ETGARFFQQP 240
  241 ALRDVSLEAF NAVASELDPV VAKRVRHVLS ENARTVEAAS ALEKGDLQRM GQLMAESHAS 300
  301 MRDDFEITVP QIDTLVDIVK ATIGDQGGVR MTGGGFGGCV VALIPEDLVP AVQQAVAQQY 360
  361 EAKTGIKETF YVCKPSQGAG QC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	84.522879
Match:	1wuuA
Description:	crystal structure of human galactokinase complexed with MgAMPPNP and galactose
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
galactokinase activity	1.98579505313408	bayes_pls_golite062009
catalytic activity	0.836142537655721	bayes_pls_golite062009
hydrolase activity	0.740929677099368	bayes_pls_golite062009
nuclease activity	0.658641254758609	bayes_pls_golite062009
binding	0.608774560880549	bayes_pls_golite062009
ribonuclease activity	0.545200648734771	bayes_pls_golite062009
galactose binding	0.199740558600278	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: