YRC Public Data Repository - Protein Structure Prediction

Protein:	FUMA_ECOLI
Organism:	Escherichia coli
Length:	548 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FUMA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|110615134, gi... - gi\|110805586\|ref\|YP_689106.1\| fumarate hydratase class I, aerobic [Shigella flexneri 5 str. 8401], g...	820.0	[0..1]	[548..1]
gi\|75195692, gi\|... - gi\|75195692\|ref\|ZP_00705762.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|75212949, gi\|... - gi\|75212949\|ref\|ZP_00712947.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|75178493, gi\|... - gi\|75178493\|ref\|ZP_00698539.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|193064911, gi... - gi\|75257031\|ref\|ZP_00728591.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|188487181, gi... - gi\|75512955\|ref\|ZP_00735436.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|190904068, gi... - gi\|75230939\|ref\|ZP_00717388.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|75234925, gi\|... - gi\|75234925\|ref\|ZP_00719204.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|124529233, gi... - gi\|124529233\|ref\|ZP_01700308.1\| hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta subunit [... gi\|73855540, gi\|... - gi\|74312063\|ref\|YP_310482.1\| fumarase A [Shigella sonnei Ss046], gi\|73855540\|gb\|AAZ88247.1\| fumarase... gi\|169754963, gi... - gi\|170020035\|ref\|YP_001724989.1\| tartrate/fumarate subfamily Fe-S type hydro-lyase beta subunit [Esc... gi\|82544021, gi\|... - gi\|82544021\|ref\|YP_407968.1\| fumarase A [Shigella boydii Sb227], gi\|81245432\|gb\|ABB66140.1\| fumarase...	818.0	[0..1]	[548..1]
gi\|194419901, gi... - gi\|83571002\|ref\|ZP_00922444.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ...	818.0	[0..1]	[548..1]
gi\|24113001, gi\|... - gi\|24113001\|ref\|NP_707511.1\| fumarase A, fumarate hydratase class I; aerobic isozyme [Shigella flexn... gi\|30041376, gi\|... - gi\|30063127\|ref\|NP_837298.1\| fumarase A, fumarate hydratase class I; aerobic isozyme [Shigella flexn...	818.0	[0..1]	[548..1]
gi\|115515532, gi... - gi\|117626408\|ref\|YP_859731.1\| anaerobic class I fumarate hydratase (fumarase B) [Escherichia coli AP... gi\|26250935, gi\|... - gi\|26250935\|ref\|NP_756975.1\| fumarate hydratase class I, anaerobic [Escherichia coli CFT073], gi\|261... gi\|191173384, gi... - gi\|75239093\|ref\|ZP_00723073.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|227886840, gi... - gi\|227886840\|ref\|ZP_04004645.1\| fumarate hydratase [Escherichia coli 83972], gi\|227836182\|gb\|EEJ4664... gi\|91075242, gi\|... - gi\|91213668\|ref\|YP_543654.1\| fumarate hydratase class I, anaerobic [Escherichia coli UTI89], gi\|9107... gi\|218367979, gi... - gi\|218561210\|ref\|YP_002394123.1\| anaerobic class I fumarate hydratase (fumarase B) [Escherichia coli... gi\|237703709, gi... - gi\|237703709\|ref\|ZP_04534190.1\| fumarate hydratase class I [Escherichia sp. 3_2_53FAA], gi\|226901621... gi\|110644479, gi... - gi\|110644479\|ref\|YP_672209.1\| fumarate hydratase class I, anaerobic [Escherichia coli 536], gi\|11034...	818.0	[0..1]	[548..1]
gi\|82777081, gi\|... - gi\|82777081\|ref\|YP_403430.1\| fumarase A [Shigella dysenteriae Sd197], gi\|81241229\|gb\|ABB61939.1\| fum...	817.0	[0..1]	[548..1]
gi\|168750576, gi... - gi\|188015239\|gb\|EDU53361.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4113], gi\|168750576\|... gi\|189355567, gi... - gi\|189355567\|gb\|EDU73986.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4401], gi\|168757474\|... gi\|168763686, gi... - gi\|189366198\|gb\|EDU84614.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4501], gi\|168763686\|... gi\|168771152, gi... - gi\|189359996\|gb\|EDU78415.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4486], gi\|168771152\|... gi\|13361785, gi\|... - gi\|15831572\|ref\|NP_310345.1\| fumarase A [Escherichia coli O157:H7 str. Sakai], gi\|13361785\|dbj\|BAB35... gi\|209397842, gi... - gi\|209397842\|ref\|YP_002270684.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4115], gi\|20915... gi\|217318312, gi... - gi\|217328965\|ref\|ZP_03445046.1\| fumarate hydratase [Escherichia coli O157:H7 str. TW14588], gi\|21731... gi\|254793229, gi... - gi\|254793229\|ref\|YP_003078066.1\| fumarate hydratase (fumarase A), aerobic Class I [Escherichia coli ... gi\|209769834, gi... - pir\|\|C85767 fumarase A [similarity] - Escherichia coli (strain O157:H7, substrain EDL933), pir\|\|F90... gi\|195939002 - gi\|195939002\|ref\|ZP_03084384.1\| fumarase A [Escherichia coli O157:H7 str. EC4024] gi\|208725276, gi... - gi\|208810760\|ref\|ZP_03252636.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4206], gi\|208725... gi\|15802026, gi\|... - gi\|15802026\|ref\|NP_288047.1\| fumarase A = fumarate hydratase class I; aerobic isozyme [Escherichia c... gi\|208817061, gi... - gi\|208817061\|ref\|ZP_03258181.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4045], gi\|208731... FUMA_ECO57 - Fumarate hydratase class I, aerobic OS=Escherichia coli O157:H7 GN=fumA PE=3 SV=3 gi\|208740192, gi... - gi\|208820069\|ref\|ZP_03260389.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4042], gi\|208740... gi\|168775840, gi... - gi\|187768714\|gb\|EDU32558.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4196], gi\|168775840\|... gi\|188999201, gi... - gi\|188999201\|gb\|EDU68187.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4076], gi\|168783433\|... gi\|168789447, gi... - gi\|189370974\|gb\|EDU89390.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC869], gi\|168789447\|r... gi\|189376931, gi... - gi\|189376931\|gb\|EDU95347.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC508], gi\|168800870\|r...	816.0	[0..1]	[548..1]
gi\|192958847, gi... - gi\|75238651\|ref\|ZP_00722640.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ...	814.0	[0..1]	[548..1]
gi\|81248034, gi\|... - gi\|82546623\|ref\|YP_410570.1\| fumarase B [Shigella boydii Sb227], gi\|81248034\|gb\|ABB68742.1\| fumarase...	814.0	[0..1]	[548..1]

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Predicted Domain #1

Region A:
Residues: [1-141]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNKPFHYQA PFPLKKDDTE YYLLTSEHVS VSEFEGQEIL KVAPEALTLL ARQAFHDASF  60
   61 MLRPAHQQQV ADILRDPEAS ENDKYVALQF LRNSDIAAKG VLPTCQDTGT AIIVGKKGQR 120
  121 VWTGGGDEAA LARGVYNTYI E

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.564	0.633	fumarate hydratase activity	a.1.1	Globin-like
View	Download	0.548	0.026	fumarate hydratase activity	a.24.10	Histidine-containing phosphotransfer domain, HPT domain
View	Download	0.507	N/A	N/A	a.1.1	Globin-like
View	Download	0.444	N/A	N/A	a.24.10	Histidine-containing phosphotransfer domain, HPT domain
View	Download	0.430	N/A	N/A	a.1.1	Globin-like

Predicted Domain #2

Region A:
Residues: [142-345]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNLRYSQNAP LDMYKEVNTG TNLPAQIDLY AVDGDEYKFL CIAKGGGSAN KTYLYQETKA  60
   61 LLTPGKLKNY LVEKMRTLGT AACPPYHIAF VIGGTSAETN LKTVKLASAK YYDELPTEGN 120
  121 EHGQAFRDVE LEKELLIEAQ NLGLGAQFGG KYFAHDIRVI RLPRHGASCP VGMGVSCSAD 180
  181 RNIKAKINRQ GIWIEKLEHN PGKY

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [346-548]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPEELRKAGE GEAVRVDLNR PMKEILAQLS QYPVSTRLSL NGTIIVGRDI AHAKLKERMD  60
   61 NGEGLPQYIK DHPIYYAGPA KTPEGYASGS LGPTTAGRMD SYVDQLQAQG GSMIMLAKGN 120
  121 RSQQVTDACK KHGGFYLGSI GGPAAVLAQG SIKSLECVEY PELGMEAIWK IEVEDFPAFI 180
  181 LVDDKGNDFF QQIQLTQCTR CVK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	62.0
Match:	2isbA
Description:	No description for 2isbA was found.

Predicted functions:

Term	Confidence	Notes
fumarate hydratase activity	4.07646355358082	bayes_pls_golite062009
catalytic activity	1.02123395223799	bayes_pls_golite062009
hydro-lyase activity	0.556078290190932	bayes_pls_golite062009
carbon-oxygen lyase activity	0.338858403016763	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: