YRC Public Data Repository - Protein Structure Prediction

Protein:	FUMA_ECOLI
Organism:	Escherichia coli
Length:	548 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FUMA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|110615134, gi... - gi\|110805586\|ref\|YP_689106.1\| fumarate hydratase class I, aerobic [Shigella flexneri 5 str. 8401], g...	820.0	[0..1]	[548..1]
gi\|75195692, gi\|... - gi\|75195692\|ref\|ZP_00705762.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|75212949, gi\|... - gi\|75212949\|ref\|ZP_00712947.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|75178493, gi\|... - gi\|75178493\|ref\|ZP_00698539.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|193064911, gi... - gi\|75257031\|ref\|ZP_00728591.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|188487181, gi... - gi\|75512955\|ref\|ZP_00735436.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|190904068, gi... - gi\|75230939\|ref\|ZP_00717388.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|75234925, gi\|... - gi\|75234925\|ref\|ZP_00719204.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|124529233, gi... - gi\|124529233\|ref\|ZP_01700308.1\| hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta subunit [... gi\|73855540, gi\|... - gi\|74312063\|ref\|YP_310482.1\| fumarase A [Shigella sonnei Ss046], gi\|73855540\|gb\|AAZ88247.1\| fumarase... gi\|169754963, gi... - gi\|170020035\|ref\|YP_001724989.1\| tartrate/fumarate subfamily Fe-S type hydro-lyase beta subunit [Esc... gi\|82544021, gi\|... - gi\|82544021\|ref\|YP_407968.1\| fumarase A [Shigella boydii Sb227], gi\|81245432\|gb\|ABB66140.1\| fumarase...	818.0	[0..1]	[548..1]
gi\|194419901, gi... - gi\|83571002\|ref\|ZP_00922444.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ...	818.0	[0..1]	[548..1]
gi\|24113001, gi\|... - gi\|24113001\|ref\|NP_707511.1\| fumarase A, fumarate hydratase class I; aerobic isozyme [Shigella flexn... gi\|30041376, gi\|... - gi\|30063127\|ref\|NP_837298.1\| fumarase A, fumarate hydratase class I; aerobic isozyme [Shigella flexn...	818.0	[0..1]	[548..1]
gi\|115515532, gi... - gi\|117626408\|ref\|YP_859731.1\| anaerobic class I fumarate hydratase (fumarase B) [Escherichia coli AP... gi\|26250935, gi\|... - gi\|26250935\|ref\|NP_756975.1\| fumarate hydratase class I, anaerobic [Escherichia coli CFT073], gi\|261... gi\|191173384, gi... - gi\|75239093\|ref\|ZP_00723073.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ... gi\|227886840, gi... - gi\|227886840\|ref\|ZP_04004645.1\| fumarate hydratase [Escherichia coli 83972], gi\|227836182\|gb\|EEJ4664... gi\|91075242, gi\|... - gi\|91213668\|ref\|YP_543654.1\| fumarate hydratase class I, anaerobic [Escherichia coli UTI89], gi\|9107... gi\|218367979, gi... - gi\|218561210\|ref\|YP_002394123.1\| anaerobic class I fumarate hydratase (fumarase B) [Escherichia coli... gi\|237703709, gi... - gi\|237703709\|ref\|ZP_04534190.1\| fumarate hydratase class I [Escherichia sp. 3_2_53FAA], gi\|226901621... gi\|110644479, gi... - gi\|110644479\|ref\|YP_672209.1\| fumarate hydratase class I, anaerobic [Escherichia coli 536], gi\|11034...	818.0	[0..1]	[548..1]
gi\|82777081, gi\|... - gi\|82777081\|ref\|YP_403430.1\| fumarase A [Shigella dysenteriae Sd197], gi\|81241229\|gb\|ABB61939.1\| fum...	817.0	[0..1]	[548..1]
gi\|168750576, gi... - gi\|188015239\|gb\|EDU53361.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4113], gi\|168750576\|... gi\|189355567, gi... - gi\|189355567\|gb\|EDU73986.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4401], gi\|168757474\|... gi\|168763686, gi... - gi\|189366198\|gb\|EDU84614.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4501], gi\|168763686\|... gi\|168771152, gi... - gi\|189359996\|gb\|EDU78415.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4486], gi\|168771152\|... gi\|13361785, gi\|... - gi\|15831572\|ref\|NP_310345.1\| fumarase A [Escherichia coli O157:H7 str. Sakai], gi\|13361785\|dbj\|BAB35... gi\|209397842, gi... - gi\|209397842\|ref\|YP_002270684.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4115], gi\|20915... gi\|217318312, gi... - gi\|217328965\|ref\|ZP_03445046.1\| fumarate hydratase [Escherichia coli O157:H7 str. TW14588], gi\|21731... gi\|254793229, gi... - gi\|254793229\|ref\|YP_003078066.1\| fumarate hydratase (fumarase A), aerobic Class I [Escherichia coli ... gi\|209769834, gi... - pir\|\|C85767 fumarase A [similarity] - Escherichia coli (strain O157:H7, substrain EDL933), pir\|\|F90... gi\|195939002 - gi\|195939002\|ref\|ZP_03084384.1\| fumarase A [Escherichia coli O157:H7 str. EC4024] gi\|208725276, gi... - gi\|208810760\|ref\|ZP_03252636.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4206], gi\|208725... gi\|15802026, gi\|... - gi\|15802026\|ref\|NP_288047.1\| fumarase A = fumarate hydratase class I; aerobic isozyme [Escherichia c... gi\|208817061, gi... - gi\|208817061\|ref\|ZP_03258181.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4045], gi\|208731... FUMA_ECO57 - Fumarate hydratase class I, aerobic OS=Escherichia coli O157:H7 GN=fumA PE=3 SV=3 gi\|208740192, gi... - gi\|208820069\|ref\|ZP_03260389.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4042], gi\|208740... gi\|168775840, gi... - gi\|187768714\|gb\|EDU32558.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4196], gi\|168775840\|... gi\|188999201, gi... - gi\|188999201\|gb\|EDU68187.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC4076], gi\|168783433\|... gi\|168789447, gi... - gi\|189370974\|gb\|EDU89390.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC869], gi\|168789447\|r... gi\|189376931, gi... - gi\|189376931\|gb\|EDU95347.1\| fumarate hydratase [Escherichia coli O157:H7 str. EC508], gi\|168800870\|r...	816.0	[0..1]	[548..1]
gi\|192958847, gi... - gi\|75238651\|ref\|ZP_00722640.1\| COG1951: Tartrate dehydratase alpha subunit/Fumarate hydratase class ...	814.0	[0..1]	[548..1]
gi\|81248034, gi\|... - gi\|82546623\|ref\|YP_410570.1\| fumarase B [Shigella boydii Sb227], gi\|81248034\|gb\|ABB68742.1\| fumarase...	814.0	[0..1]	[548..1]

Back

Predicted Domain #1

Region A:
Residues: [1-141]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNKPFHYQA PFPLKKDDTE YYLLTSEHVS VSEFEGQEIL KVAPEALTLL ARQAFHDASF  60
   61 MLRPAHQQQV ADILRDPEAS ENDKYVALQF LRNSDIAAKG VLPTCQDTGT AIIVGKKGQR 120
  121 VWTGGGDEAA LARGVYNTYI E

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [142-345]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNLRYSQNAP LDMYKEVNTG TNLPAQIDLY AVDGDEYKFL CIAKGGGSAN KTYLYQETKA  60
   61 LLTPGKLKNY LVEKMRTLGT AACPPYHIAF VIGGTSAETN LKTVKLASAK YYDELPTEGN 120
  121 EHGQAFRDVE LEKELLIEAQ NLGLGAQFGG KYFAHDIRVI RLPRHGASCP VGMGVSCSAD 180
  181 RNIKAKINRQ GIWIEKLEHN PGKY

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [346-548]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPEELRKAGE GEAVRVDLNR PMKEILAQLS QYPVSTRLSL NGTIIVGRDI AHAKLKERMD  60
   61 NGEGLPQYIK DHPIYYAGPA KTPEGYASGS LGPTTAGRMD SYVDQLQAQG GSMIMLAKGN 120
  121 RSQQVTDACK KHGGFYLGSI GGPAAVLAQG SIKSLECVEY PELGMEAIWK IEVEDFPAFI 180
  181 LVDDKGNDFF QQIQLTQCTR CVK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	62.0
Match:	2isbA
Description:	No description for 2isbA was found.

Predicted functions:

Term	Confidence	Notes
fumarate hydratase activity	4.07646355358082	bayes_pls_golite062009
catalytic activity	1.02123395223799	bayes_pls_golite062009
hydro-lyase activity	0.556078290190932	bayes_pls_golite062009
carbon-oxygen lyase activity	0.338858403016763	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: