YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|158257308, gi...
Organism:	Homo sapiens
Length:	534 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|158257308, gi....

Description	E-value	Query Range	Subject Range
gi\|73979195 - gi\|73979195\|ref\|XP_848878.1\| PREDICTED: similar to Set1/Ash2 histone methyltransferase complex subun...	0.0	[1..534]	[95..628]
ASH2L - ash2 (absent, small, or homeotic)-like (Drosophila) gi\|168277868 - gi\|168277868\|dbj\|BAG10912.1\| Set1/Ash2 histone methyltransferase complex subunit ASH2 [synthetic con...	0.0	[1..534]	[95..628]
ASH2L_MOUSE - Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Mus musculus GN=Ash2l PE=1 SV=1	0.0	[1..534]	[90..623]
gi\|76655880, gi\|... - gi\|76655880\|ref\|XP_870662.1\| PREDICTED: similar to Set1/Ash2 histone methyltransferase complex subun...	0.0	[1..534]	[96..629]
gi\|114619679 - gi\|114619679\|ref\|XP_001170172.1\| PREDICTED: ash2 (absent, small, or homeotic)-like isoform 4 [Pan tr...	0.0	[1..534]	[95..628]

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Predicted Domain #1

Region A:
Residues: [1-88]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTQAGSVDE ENGRQLGEVE LQCGICTKWF TADTFGIDTS SCLPFMTNYS FHCNVCHHSG  60
   61 NTYFLRKQAN LKEMCLSALA NLTWQSRT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	7.522879
Match:	2egpA
Description:	No description for 2egpA was found.

Predicted Domain #2

Region A:
Residues: [89-239]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDEHPKTMFS KDKDIIPFID KYWECMTTRQ RPGKMTWPNN IVKTMSKERD VFLVKEHPDP  60
   61 GSKDPEEDYP KFGLLDQDLS NIGPAYDNQK QSSAVSTSGN LNGGIAAGSS GKGRGAKRKQ 120
  121 QDGGTTGTTK KARSDPLFSA QRLPPHGYPL E

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [240-534]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HPFNKDGYRY ILAEPDPHAP DPEKLELDCW AGKPIPGDLY RACLYERVLL ALHDRAPQLK  60
   61 ISDDRLTVVG EKGYSMVRAS HGVRKGAWYF EITVDEMPPD TAARLGWSQP LGNLQAPLGY 120
  121 DKFSYSWRSK KGTKFHQSIG KHYSSGYGQG DVLGFYINLP EDTETAKSLP DTYKDKALIK 180
  181 FKSYLYFEEK DFVDKAEKSL KQTPHSEIIF YKNGVNQGVA YKDIFEGVYF PAISLYKSCT 240
  241 VSINFGPCFK YPPKDLTYRP MSDMGWGAVV EHTLADVLYH VETEVDGRRS PPWEP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.0
Match:	2fnjA
Description:	No description for 2fnjA was found.

Predicted functions:

Term	Confidence	Notes
binding	2.40096962515027	bayes_pls_golite062009
transcription regulator activity	2.15398264148864	bayes_pls_golite062009
nucleic acid binding	1.95513305822187	bayes_pls_golite062009
protein binding	1.80794638640093	bayes_pls_golite062009
DNA binding	1.80079581406991	bayes_pls_golite062009
transcription activator activity	1.26528137349343	bayes_pls_golite062009
transcription factor activity	1.15427978494805	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: