YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|7469420
Organism:	Synechocystis sp.
Length:	538 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|7469420.

Description	E-value	Query Range	Subject Range
gi\|23125855, gi\|... - gi\|23125855\|ref\|ZP_00107772.1\| COG1587: Uroporphyrinogen-III synthase [Nostoc punctiforme PCC 73102]...	423.0	[0..28]	[534..1]
gi\|25315418 - pir\|\|AC2237 uroporphyrinogen III methylase [imported] - Nostoc sp. (strain PCC 7120) gi\|17230942, gi\|... - gi\|17230942\|ref\|NP_487490.1\| uroporphyrinogen III methylase [Nostoc sp. PCC 7120], gi\|17132583\|dbj\|B...	421.0	[0..35]	[533..6]
gi\|45510631, gi\|... - gi\|75909680\|ref\|YP_323976.1\| uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferas...	420.0	[0..35]	[536..6]
gi\|51245586, gi\|... - gi\|51245586\|ref\|YP_065470.1\| uroporphyrinogen III synthase/methyltransferase (HemD+CobA) [Desulfotal...	414.0	[0..35]	[534..11]
gi\|88945102, gi\|... - gi\|88945102\|ref\|ZP_01148322.1\| Uroporphyrin-III C-methyltransferase, C-terminal [Desulfotomaculum re...	414.0	[0..32]	[534..3]
gi\|71489436, gi\|... - gi\|71544542\|ref\|ZP_00665566.1\| Uroporphyrin-III C-methyltransferase, C-terminal [Syntrophobacter fum...	411.0	[0..32]	[535..1]
gi\|12655814 - gi\|12655814\|gb\|AAK00606.1\|AF221100_3 uroporphyrinogen III synthase/methyltransferase [Selenomonas ru...	409.0	[0..33]	[532..4]
gi\|48845542, gi\|... - gi\|78224426\|ref\|YP_386173.1\| uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferas...	409.0	[0..34]	[537..8]
gi\|109645297, gi... - gi\|68208394\|ref\|ZP_00560513.1\| Uroporphyrin-III C-methyltransferase, C-terminal [Desulfitobacterium ...	408.0	[0..34]	[532..3]
gi\|71671160, gi\|... - gi\|71675692\|ref\|ZP_00673436.1\| Uroporphyrin-III C-methyltransferase, C-terminal [Trichodesmium eryth...	406.0	[0..36]	[535..2]

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Predicted Domain #1

Region A:
Residues: [1-274]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEKLPHPQC LGVPGRSPRR ESNLIFTMLS TDSRAKVYLM GAGLGPVAYL TQRAIAVLGR  60
   61 ANVVIYDALV SQELFDLLPP DCERIFVGKR GGQPSTPQAK INQLLVDHYR RGKQVVRLKS 120
  121 GDPWIFGRIM PELATLVTHH CAYEVVPGIS SAIAGAGLAS IPLTAKDSGA GFFVMDGHDP 180
  181 HRWPWPALAQ LPTLVILMGT KNLSLLVNEL VRAGKSPHTP MAVIKNAGRP EQQTWEGTLA 240
  241 DMVEKTQGQS LAPAVIVIGD VVSQRIIPAL PPLP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	64.09691
Match:	1pjqA
Description:	Structure and function of CysG, the multifunctional methyltransferase/dehydrogenase/ferrochelatase for siroheme synthesis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uroporphyrin-III C-methyltransferase activity	3.573271502205	bayes_pls_golite062009
C-methyltransferase activity	3.35393353163232	bayes_pls_golite062009
precorrin-4 C11-methyltransferase activity	2.18371138649366	bayes_pls_golite062009
catalytic activity	1.48349578618275	bayes_pls_golite062009
transferase activity	0.912524944496351	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.431791521097299	bayes_pls_golite062009
methyltransferase activity	0.424918406685891	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.28351517300952	bayes_pls_golite062009
uroporphyrinogen-III synthase activity	0.00871858903098705	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [275-538]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTEKTILVTR AADQASQFTE LLHQQGATVL AMAALEIVPP KDWQPLDQAI AKLGDFDWLI  60
   61 LTSANGVEFF FQRLQHHGLD SRALAGLKLA VVGKKTAQSL EKFGLKPDFI PPDFIADALV 120
  121 EHFPHSPAGL KILFPRVESG GRAQLVQELS QKQALVTEVP SYQSACPGHM PEEVWQSIVN 180
  181 QTVDVITFAS SKTVSHFRQL LAQTSQANGY QDWRSLINHC QIASIGPQTS ERCLRELGRV 240
  241 DIEATEYTLE GLTGAITNYV YQNP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	37.69897
Match:	1jr2A
Description:	Uroporphyrinogen III synthase (U3S, HemD)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uroporphyrinogen-III synthase activity	3.34629127241283	bayes_pls_golite062009
catalytic activity	1.13824203225664	bayes_pls_golite062009
lyase activity	0.352588988142348	bayes_pls_golite062009
hydro-lyase activity	0.290711782955013	bayes_pls_golite062009
carbon-oxygen lyase activity	0.212880565996123	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: