YRC Public Data Repository - Protein Structure Prediction

Protein:	FOLD_STRPN
Organism:	Streptococcus pneumoniae
Length:	285 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FOLD_STRPN.

Description	E-value	Query Range	Subject Range
FOLD_MAGMM - Bifunctional protein FolD OS=Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1) GN=folD... sp\|A0LE04\|FOLD_MAGMM - Bifunctional protein FolD OS=Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1) GN=folD...	419.0	[0..1]	[283..1]
gi\|15458321, gi\|... - gi\|15902773\|ref\|NP_358323.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cycloh... gi\|25284854 - pir\|\|A97963 methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) folD [imported] - Streptococcus pne...	413.0	[0..1]	[285..22]
FOLD_MOOTA - Bifunctional protein FolD OS=Moorella thermoacetica (strain ATCC 39073) GN=folD PE=3 SV=1	411.0	[0..2]	[280..3]
gi\|77172056, gi\|... - gi\|77409324\|ref\|ZP_00786027.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cycl... gi\|76585577, gi\|... - gi\|76799062\|ref\|ZP_00781254.1\| methenyltetrahydrofolate cyclohydrolase folD [Streptococcus agalacti... FOLD_STRA5 - Bifunctional protein FolD OS=Streptococcus agalactiae serotype V GN=folD PE=3 SV=1 FOLD_STRA3 - Bifunctional protein FolD OS=Streptococcus agalactiae serotype III GN=folD PE=3 SV=1 FOLD_STRA1 - Bifunctional protein FolD OS=Streptococcus agalactiae serotype Ia GN=folD PE=3 SV=1 FOLD_STRA3 - Bifunctional protein FolD OS=Streptococcus agalactiae serotype III (strain NEM316) GN=folD PE=3 SV=1 FOLD_STRA1 - Bifunctional protein FolD OS=Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS... FOLD_STRA5 - Bifunctional protein FolD OS=Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) GN... gi\|77405305, gi\|... - gi\|77405305\|ref\|ZP_00782401.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cycl... gi\|77159936, gi\|... - gi\|77414010\|ref\|ZP_00790182.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cycl... gi\|77412380, gi\|... - gi\|77412380\|ref\|ZP_00788690.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cycl...	409.0	[0..1]	[283..1]
gi\|116515868, gi... - gi\|116515868\|ref\|YP_816214.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclo...	407.0	[0..1]	[285..8]
gi\|67153449 - gi\|67153449\|ref\|ZP_00415194.1\| Methenyltetrahydrofolate cyclohydrolase [Azotobacter vinelandii AvOP] FOLD_AZOVD - Bifunctional protein FolD OS=Azotobacter vinelandii (strain DJ / ATCC BAA-1303) GN=folD PE=3 SV=1	406.0	[0..2]	[283..3]
gi\|114550889, gi... - gi\|114778854\|ref\|ZP_01453653.1\| 5,10-methylene-tetrahydrofolate dehydrogenase/cyclohydrolase [Maripr...	405.0	[0..2]	[284..6]
gi\|71802930, gi\|... - gi\|71903835\|ref\|YP_280638.1\| methenyltetrahydrofolate cyclohydrolase [Streptococcus pyogenes MGAS618...	405.0	[0..1]	[280..3]
gi\|50914600, gi\|... - gi\|50914600\|ref\|YP_060572.1\| methenyltetrahydrofolate cyclohydrolase [Streptococcus pyogenes MGAS103... gi\|94542366, gi\|... - gi\|94988858\|ref\|YP_596959.1\| methenyltetrahydrofolate cyclohydrolase [Streptococcus pyogenes MGAS942... gi\|94992749, gi\|... - gi\|94992749\|ref\|YP_600848.1\| methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofol... gi\|94544267, gi\|... - gi\|94990759\|ref\|YP_598859.1\| methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofol... gi\|56808399 - gi\|56808399\|ref\|ZP_00366151.1\| COG0190: 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetra... gi\|94548245, gi\|... - gi\|94994737\|ref\|YP_602835.1\| Methylenetetrahydrofolate dehydrogenase (NADP+) / Methenyltetrahydrofol...	404.0	[0..1]	[280..3]
gi\|71853829, gi\|... - gi\|71911047\|ref\|YP_282597.1\| methylenetetrahydrofolate dehydrogenase (NADP+)/methenyltetrahydrofolat... FOLD_STRP8 - Bifunctional protein FolD OS=Streptococcus pyogenes serotype M18 (strain MGAS8232) GN=folD PE=3 SV=1 FOLD_STRP8 - Bifunctional protein FolD OS=Streptococcus pyogenes serotype M18 GN=folD PE=3 SV=1 gi\|15675405, gi\|... - gi\|15675405\|ref\|NP_269579.1\| putative bifunctional methylenetetrahydrofolate dehydrogenase / metheny... FOLD_STRP1 - Bifunctional protein FolD OS=Streptococcus pyogenes serotype M1 GN=folD PE=3 SV=1 FOLD_STRPM - Bifunctional protein FolD OS=Streptococcus pyogenes serotype M28 GN=folD PE=3 SV=2 FOLD_STRPM - Bifunctional protein FolD OS=Streptococcus pyogenes serotype M28 (strain MGAS6180) GN=folD PE=3 SV=2	404.0	[0..1]	[280..1]

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Predicted Domain #1

Region A:
Residues: [1-285]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQIIDGKAL AAKLQGQLAE KTAKLKEETG LVPGLVVILV GDNPASQVYV RNKERSALAA  60
   61 GFRSEVVRVP ETITQEELLD LIAKYNQDPA WHGILVQLPL PKHIDEEAVL LAIDPEKDVD 120
  121 GFHPLNMGRL WSGHPVMIPS TPAGIMEMFH EYGIDLEGKN AVVIGRSNIV GKPMAQLLLA 180
  181 KNATVTLTHS RTHNLSKVAA KADILVVAIG RAKFVTADFV KPGAVVIDVG MNRDENGKLC 240
  241 GDVDYEAVAP LASHITPVPG GVGPMTITML MEQTYQAALR TLDRK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	111.0
Match:	1b0aA
Description:	Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.0643953589843	bayes_pls_golite062009
malate dehydrogenase activity	1.78748747782382	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.43144163429682	bayes_pls_golite062009
oxidoreductase activity	1.39032308236663	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	1.2593557953787	bayes_pls_golite062009
malic enzyme activity	0.607811499947861	bayes_pls_golite062009
DNA binding	0.525227236870065	bayes_pls_golite062009
nucleic acid binding	0.459537641913493	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.39426299750207	bayes_pls_golite062009
transcription regulator activity	0.152651308844322	bayes_pls_golite062009
cyclohydrolase activity	0.129148522173579	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: