YRC Public Data Repository - Protein Structure Prediction

Protein:	HPRT_STAAR
Organism:	Staphylococcus aureus subsp. aureus MRSA252
Length:	179 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HPRT_STAAR.

Description	E-value	Query Range	Subject Range
TILS_LISIN - Bifunctional protein TilS/HprT OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=tilS/hprT PE=3 ... TILS_LISIN - Bifunctional protein tilS/hprT OS=Listeria innocua GN=tilS/hprT PE=3 SV=1	167.0	[0..1]	[178..470]
gi\|224500330 - gi\|224500330\|ref\|ZP_03668679.1\| hypothetical protein LmonF1_11939 [Listeria monocytogenes Finland 19... gi\|224503461 - gi\|224503461\|ref\|ZP_03671768.1\| hypothetical protein LmonFR_13287 [Listeria monocytogenes FSL R2-561... gi\|126941298, gi... - gi\|254900996\|ref\|ZP_05260920.1\| hypothetical protein LmonJ_14318 [Listeria monocytogenes J0161], gi\|... gi\|254913936, gi... - gi\|254913936\|ref\|ZP_05263948.1\| hypothetical protein LmonJ2_14108 [Listeria monocytogenes J2818], gi... gi\|133733948, gi... - gi\|254938274\|ref\|ZP_05269971.1\| hypothetical protein LmonF6_14141 [Listeria monocytogenes F6900], gi... gi\|47014358, gi\|... - gi\|47097258\|ref\|ZP_00234818.1\| conserved hypothetical protein/hypoxanthine phosphoribosyltransferase... TILS_LISMO - Bifunctional protein TilS/HprT OS=Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) ... TILS_LISMO - Bifunctional protein tilS/hprT OS=Listeria monocytogenes GN=tilS/hprT PE=3 SV=1	167.0	[0..1]	[178..470]
TILS_LISMF - Bifunctional protein TilS/HprT OS=Listeria monocytogenes serotype 4b (strain F2365) GN=tilS/hprT PE=...	166.0	[0..1]	[178..470]
gi\|226222848, gi... - gi\|226222848\|ref\|YP_002756955.1\| hypothetical protein Lm4b_00217 [Listeria monocytogenes Clip81459],... gi\|47018468, gi\|... - gi\|47093161\|ref\|ZP_00230936.1\| conserved hypothetical protein/hypoxanthine phosphoribosyltransferase... gi\|21667249 - gi\|21667249\|gb\|AAM74001.1\|AF467001_2 YacA/HprT-like protein [Listeria monocytogenes] gi\|153200654, gi... - gi\|254933059\|ref\|ZP_05266418.1\| hypothetical protein LmonH_11532 [Listeria monocytogenes HPB2262], g...	166.0	[0..1]	[178..470]
HPRT_ENTFA - Hypoxanthine-guanine phosphoribosyltransferase OS=Enterococcus faecalis GN=hpt PE=3 SV=1 gi\|227072597, gi... - gi\|227520049\|ref\|ZP_03950098.1\| hypoxanthine-guanine phosphoribosyltransferase [Enterococcus faecali... HPRT_ENTFA - Hypoxanthine-guanine phosphoribosyltransferase OS=Enterococcus faecalis (strain ATCC 700802 / V583) ... gi\|227174967, gi... - gi\|227555910\|ref\|ZP_03985957.1\| hypoxanthine-guanine phosphoribosyltransferase [Enterococcus faecali... gi\|238857927, gi... - gi\|238857927\|ref\|ZP_04648156.1\| hypoxanthine phosphoribosyltransferase [Enterococcus faecalis TUSoD ...	159.0	[0..1]	[179..2]
gi\|116077257, gi... - gi\|116516681\|ref\|YP_815435.1\| hypoxanthine-guanine phosphoribosyltransferase [Streptococcus pneumoni... gi\|225853623, gi... - gi\|225853623\|ref\|YP_002735135.1\| hypoxanthine phosphoribosyltransferase [Streptococcus pneumoniae JJ... gi\|221230960, gi... - gi\|221230960\|ref\|YP_002510112.1\| hypoxanthine-guanine phosphoribosyltransferase [Streptococcus pneum... HPRT_STRR6 - Hypoxanthine-guanine phosphoribosyltransferase OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6... HPRT_STRPN - Hypoxanthine-guanine phosphoribosyltransferase OS=Streptococcus pneumoniae GN=hpt PE=3 SV=1 HPRT_STRPN - Hypoxanthine-guanine phosphoribosyltransferase OS=Streptococcus pneumoniae serotype 4 (strain ATCC B... gi\|147762895, gi... - gi\|149013372\|ref\|ZP_01834081.1\| hypoxanthine phosphoribosyltransferase [Streptococcus pneumoniae SP1... gi\|148993573, gi... - gi\|148993573\|ref\|ZP_01823044.1\| hypoxanthine phosphoribosyltransferase [Streptococcus pneumoniae SP9... gi\|148988916, gi... - gi\|148988916\|ref\|ZP_01820331.1\| hypoxanthine phosphoribosyltransferase [Streptococcus pneumoniae SP6... gi\|168484296, gi... - gi\|172042419\|gb\|EDT50465.1\| hypoxanthine phosphoribosyltransferase [Streptococcus pneumoniae CDC1873... gi\|147923333, gi... - gi\|148984556\|ref\|ZP_01817844.1\| hypoxanthine phosphoribosyltransferase [Streptococcus pneumoniae SP3... gi\|168493988, gi... - gi\|183575891\|gb\|EDT96419.1\| hypoxanthine phosphoribosyltransferase [Streptococcus pneumoniae CDC3059... gi\|168489347, gi... - gi\|183572298\|gb\|EDT92826.1\| hypoxanthine phosphoribosyltransferase [Streptococcus pneumoniae SP195],... gi\|194397408, gi... - gi\|194397408\|ref\|YP_002036733.1\| hypoxanthine-guanine phosphoribosyltransferase [Streptococcus pneum... gi\|182628315, gi... - gi\|182682981\|ref\|YP_001834728.1\| hypoxanthine-guanine phosphoribosyltransferase [Streptococcus pneum...	158.0	[0..1]	[179..2]
gi\|87161299\|ref\|... - hypoxanthine phosphoribosyltransferase [Staphylococcus aureus subsp. aureus USA300], hypoxanthine ph... gi\|87161299, gi\|... - gi\|87161299\|ref\|YP_493197.1\| hypoxanthine phosphoribosyltransferase [Staphylococcus aureus subsp. au...	156.0	[0..1]	[179..5]
gi\|90821520, gi\|... - gi\|90962326\|ref\|YP_536242.1\| hypoxanthine-guanine phosphoribosyltransferase [Lactobacillus salivariu...	155.0	[0..1]	[178..1]
gi\|74490731, gi\|... - gi\|75761781\|ref\|ZP_00741717.1\| Hypoxanthine-guanine phosphoribosyltransferase [Bacillus thuringiensi... gi\|218895200, gi... - gi\|218895200\|ref\|YP_002443611.1\| hypoxanthine phosphoribosyltransferase [Bacillus cereus G9842], gi\|...	154.0	[0..1]	[179..2]
gi\|116098531, gi... - gi\|116333184\|ref\|YP_794711.1\| hypoxanthine-guanine phosphoribosyltransferase [Lactobacillus brevis A...	154.0	[0..1]	[179..1]

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Predicted Domain #1

Region A:
Residues: [1-179]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHNDLKEVLL TEEDIQNICK ELGAQLTKDY QGKPLVCVGI LKGSAMFMSD LIKRIDTHLS  60
   61 IDFMDVSSYH GGTESTGEVQ IIKDLGSSIE NKDVLIIEDI LETGTTLKSI TELLQSRKVN 120
  121 SLEIVTLLDK PNRRKADIEA KYVGKKIPDE FVVGYGLDYR ELYRNLPYIG TLKPEVYSN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.09691
Match:	1r3uA
Description:	Crystal Structure of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
adenine phosphoribosyltransferase activity	4.07252508868782	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	3.91023158228049	bayes_pls_golite062009
hypoxanthine phosphoribosyltransferase activity	3.89356447922614	bayes_pls_golite062009
transferase activity	2.73727660668741	bayes_pls_golite062009
nucleobase binding	2.70671399975507	bayes_pls_golite062009
purine binding	2.63033967717893	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	2.53679639481311	bayes_pls_golite062009
uracil phosphoribosyltransferase activity	2.36237864658341	bayes_pls_golite062009
catalytic activity	2.30431811394775	bayes_pls_golite062009
amidophosphoribosyltransferase activity	1.6596316647688	bayes_pls_golite062009
ribose phosphate diphosphokinase activity	1.51875493459374	bayes_pls_golite062009
protein binding	1.02514711359042	bayes_pls_golite062009
adenine binding	0.817887117933035	bayes_pls_golite062009
diphosphotransferase activity	0.749909396904601	bayes_pls_golite062009
binding	0.644392905117932	bayes_pls_golite062009
nucleic acid binding	0.439453264070391	bayes_pls_golite062009
transcription regulator activity	0.369893745269311	bayes_pls_golite062009
DNA binding	0.275043319532312	bayes_pls_golite062009
orotate phosphoribosyltransferase activity	0.148898393751978	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: